Cell therapy for liver disorders: past, present and future

Nature Reviews Gastroenterology & Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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Not the end of the road for macrophage therapy in liver cirrhosis

Nature Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Язык: Английский

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Role of IL‐34 in Tumors and Its Application to Regulate Inflammation

Cancer Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

ABSTRACT Interleukin (IL)‐34 is a relatively recently discovered cytokine which binds to colony‐stimulating factor‐1 receptor (CSF‐1R). So far, there has been no clear explanation as why CSF‐1R requires two ligands. While CSF‐1 ubiquitously expressed, the expression of IL‐34 restricted. However, it revealed that increases in various diseases and associated with their pathology. Naturally, both stimulate CSF‐1R, thereby contributing differentiation monocytes into macrophages. In many cases, induced macrophages significantly influence disease particular, we have demonstrated cancer deeply involved tumor progression therapeutic resistance. We shown blockade improved efficacy such chemotherapy, radiotherapy, immune checkpoint against IL‐34‐expressing cancers. Recently, since by exhibit immunosuppressive properties, whereas can enhance inflammation, growing interest actively regulating inflammation utilizing IL‐34. this review article, provide an overview characteristics roles discuss how could be applied future diagnostics therapeutics.

Язык: Английский

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Macrophage therapy and liver regeneration: results and perspectives

Clinics and Research in Hepatology and Gastroenterology, Год журнала: 2025, Номер unknown, С. 102569 - 102569

Опубликована: Март 1, 2025

Язык: Английский

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New insights into therapeutic strategies for targeting hepatic macrophages to alleviate liver fibrosis

International Immunopharmacology, Год журнала: 2025, Номер 158, С. 114864 - 114864

Опубликована: Май 15, 2025

Язык: Английский

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Reviewing the function of macrophages in liver diseases

Expert Review of Gastroenterology & Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

The liver is a central metabolic organ, but also hosting unique immune microenvironment to sustain homeostasis and proper defense measures against injury threats in healthy individuals. Liver macrophages, mostly represented by the tissue-resident Kupffer cells bone marrow- or monocyte-derived are intricately involved various aspects of disease, including tissue injury, inflammation, fibrogenesis repair mechanisms. We review recent findings on defining macrophage landscape their functions diseases with aim highlighting potential targets for therapeutic interventions. A comprehensive literature search PubMed Google Scholar was conducted identify relevant up date. macrophages orchestrate key homeostatic pathogenic processes liver. Thus, targeting represents an attractive strategy drug development, e.g. ameliorate steatohepatitis fibrosis. However, translation from fundamental research therapies remains challenging due versatile nature compartment. Recent major technical advances such as single-cell spatially-resolved omics approaches deepened our understanding biology at molecular level. Yet, further studies needed suitable, etiology- stage-dependent strategies treatment diseases.

Язык: Английский

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Autologous macrophage therapy for compensated cirrhosis, some hope at the horizon

Journal of Hepatology, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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