Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 20, 2022
Stroke
is
one
of
the
leading
causes
mortality,
and
survivors
experience
serious
neurological
motor
behavioral
deficiencies.
Following
a
cerebral
ischemic
event,
substantial
alterations
in
both
cellular
molecular
activities
occur
because
ischemia/reperfusion
injury.
Wnt
signaling
an
evolutionarily
conserved
pathway
that
has
been
manifested
to
play
key
role
embryo
development
function
maintenance
adults.
Overactivation
previously
investigated
cancer-based
research
studies.
Recently,
abnormal
activity
observed
stroke,
which
accompanied
by
massive
blood–brain
barrier
(BBB)
disruption,
neuronal
apoptosis,
neuroinflammation
within
central
nervous
system
(CNS).
Significant
therapeutic
effects
were
after
reactivating
adynamic
canonical
different
cell
types.
To
better
understand
potential
as
novel
target
for
we
reviewed
pathogenesis
stroke
types,
including
endothelial
cells,
neurons,
oligodendrocytes,
microglia.
A
comprehensive
understanding
among
cells
may
help
evaluate
its
value
strategies
based
on
activation
can
ameliorate
complications
improve
functional
rehabilitation
stroke.
Frontiers in Aging Neuroscience,
Год журнала:
2021,
Номер
13
Опубликована: Окт. 20, 2021
Structural
and
functional
integrity
of
the
cerebral
vasculature
ensures
proper
brain
development
function,
as
well
healthy
aging.
The
inability
to
store
energy
makes
it
exceptionally
dependent
on
an
adequate
supply
oxygen
nutrients
from
blood
stream
for
matching
colossal
demands
neural
glial
cells.
Key
vascular
features
including
a
dense
vasculature,
tightly
controlled
environment,
regulation
flow
(CBF)
all
take
part
in
health
throughout
life.
As
such,
aging
are
both
ensured
by
anatomical
interaction
between
nervous
systems
that
established
during
maintained
lifespan.
During
critical
periods
development,
networks
remodel
until
they
can
actively
respond
increases
activity
through
neurovascular
coupling,
which
particularly
vulnerable
alterations.
has
been
strongly
associated
with
onset
and/or
progression
conditions
aging,
more
recently
neurodevelopmental
disorders.
Our
understanding
cerebrovascular
contributions
neurological
disorders
is
rapidly
evolving,
increasing
evidence
shows
deficits
angiogenesis,
CBF
blood-brain
barrier
(BBB)
causally
linked
cognitive
impairment.
Moreover,
utmost
curiosity
although
neurodegenerative
express
different
clinical
at
stages
life,
share
similar
abnormalities.
In
this
review,
we
present
overview
dysfunctions
(autism
spectrum
disorders,
schizophrenia,
Down
Syndrome)
(multiple
sclerosis,
Huntington’s,
Parkinson’s,
Alzheimer’s
diseases)
focus
impairments
BBB.
Finally,
discuss
impact
early
expression
diseases.
Cells,
Год журнала:
2022,
Номер
11(5), С. 813 - 813
Опубликована: Фев. 25, 2022
The
neurovascular
unit
(NVU)
is
a
conceptual
framework
that
has
been
proposed
to
better
explain
the
relationships
between
neural
cells
and
blood
vessels
in
human
brain,
focused
mainly
on
brain
gray
matter.
major
components
of
NVU
are
neurons,
astrocytes
(astroglia),
microvessels,
pericytes,
microglia.
In
addition,
we
believe
oligodendrocytes
should
also
be
included
as
an
indispensable
component
white
Of
all
these
components,
particular
have
attracted
interest
researchers
because
their
unique
anatomical
location;
interposed
neurons
microvessels
brain.
Their
location
suggests
might
regulate
cerebral
flow
(CBF)
response
neuronal
activity,
so
ensure
adequate
supply
glucose
oxygen
meet
metabolic
demands
neurons.
fact,
adult
which
accounts
for
only
2%
entire
body
weight,
consumes
approximately
20–25%
total
amount
consumed
by
whole
body.
needs
continuous
essential
energy
sources
through
CBF,
there
practically
no
stores
or
brain;
both
acute
chronic
cessation
CBF
can
adversely
affect
functions.
another
important
putative
function
elimination
heat
waste
materials
produced
activity.
Recent
evidence
play
pivotal
roles
not
supplying
glucose,
but
fatty
acids
amino
Loss
astrocytic
support
expected
lead
malfunction
whole,
underlies
numerous
neurological
disorders.
this
review,
shall
focus
historical
recent
findings
with
regard
contributions
NVU.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Май 20, 2022
Stroke
is
one
of
the
leading
causes
mortality,
and
survivors
experience
serious
neurological
motor
behavioral
deficiencies.
Following
a
cerebral
ischemic
event,
substantial
alterations
in
both
cellular
molecular
activities
occur
because
ischemia/reperfusion
injury.
Wnt
signaling
an
evolutionarily
conserved
pathway
that
has
been
manifested
to
play
key
role
embryo
development
function
maintenance
adults.
Overactivation
previously
investigated
cancer-based
research
studies.
Recently,
abnormal
activity
observed
stroke,
which
accompanied
by
massive
blood–brain
barrier
(BBB)
disruption,
neuronal
apoptosis,
neuroinflammation
within
central
nervous
system
(CNS).
Significant
therapeutic
effects
were
after
reactivating
adynamic
canonical
different
cell
types.
To
better
understand
potential
as
novel
target
for
we
reviewed
pathogenesis
stroke
types,
including
endothelial
cells,
neurons,
oligodendrocytes,
microglia.
A
comprehensive
understanding
among
cells
may
help
evaluate
its
value
strategies
based
on
activation
can
ameliorate
complications
improve
functional
rehabilitation
stroke.
