Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 30, 2025
Abstract
Oligodendrocyte
precursor
cells
(OPCs)
shape
brain
function
through
many
non-canonical
regulatory
mechanisms
beyond
myelination.
Here
we
show
that
OPCs
form
contacts
with
their
processes
on
neuronal
somata
in
a
activity-dependent
manner.
These
facilitate
exocytosis
of
lysosomes.
A
reduction
the
number
or
branching
reduces
these
contacts,
which
is
associated
lysosome
accumulation
and
altered
metabolism
neurons
more
senescent
age.
similar
OPC
seen
an
early-stage
mouse
model
Alzheimer’s
disease.
Our
findings
have
implications
for
prevention
age-related
pathologies
treatment
neurodegenerative
diseases.
Frontiers in Molecular Neuroscience,
Год журнала:
2025,
Номер
18
Опубликована: Март 27, 2025
A
traumatic
injury
to
the
nervous
system
has
significant
consequences
for
mammals,
including
long-term
disability,
loss
of
functions,
and
neuropathic
pain.
In
contrast
zebrafish
(
Danio
rerio
)
exhibits
a
markedly
enhanced
neuroregenerative
capacity,
which
can
be
attributed
phenomenon
adult
neurogenesis
distinctive
characteristics
inflammatory
response
at
site.
The
post-traumatic
recovery
under
different
experimental
conditions
was
demonstrated
in
numerous
studies,
substantially
advanced
our
understanding
cellular
molecular
mechanisms
neuroregeneration
this
animal.
view
differences
depending
on
site,
lesion
severity,
harmful
agents,
selecting
an
appropriate
model
investigations
is
paramount
importance.
This
review
discusses
some
approaches
modeling
neural
considers
effect
interactions
neurogenesis,
with
focus
animal’s
age
specific
damaging
factor
that
may
used
select
optimum
certain
lesions.
Frontiers in Cellular Neuroscience,
Год журнала:
2025,
Номер
19
Опубликована: Апрель 10, 2025
The
development
of
the
nervous
system
is
a
highly
complex
process
orchestrated
by
multitude
factors,
including
various
immune
elements.
These
components
play
dual
role,
not
only
regulating
response
but
also
actively
influencing
brain
under
both
physiological
and
pathological
conditions.
brain’s
barrier
includes
microglia
in
parenchyma,
which
act
as
resident
macrophages,
astrocytes
that
support
neuronal
function
contribute
to
inflammatory
response,
well
circulating
cells
reside
at
borders,
choroid
plexus,
meninges,
perivascular
spaces.
Cytokines—soluble
signaling
molecules
released
cells—play
crucial
role
mediating
communication
between
developing
system.
Cytokines
regulate
processes
such
neurogenesis,
synaptic
pruning,
inflammation,
helping
shape
neural
environment.
Dysregulation
these
cells,
astrocytes,
or
cytokine
can
lead
alterations
neurodevelopment,
potentially
contributing
neurodevelopmental
abnormalities.
This
article
reviews
central
microglia,
cytokines,
other
factors
explores
how
neuroinflammation
onset
disorders,
shedding
new
light
on
their
pathogenesis.
PLoS Biology,
Год журнала:
2024,
Номер
22(7), С. e3002655 - e3002655
Опубликована: Июль 10, 2024
Oligodendrocyte
precursor
cells
(OPCs)
are
a
class
of
glial
that
uniformly
tiles
the
entire
central
nervous
system
(CNS).
They
play
several
key
functions
across
brain
including
generation
oligodendrocytes
and
control
myelination.
Whether
functional
diversity
OPCs
is
result
genetically
defined
subpopulations
or
their
regulation
by
external
factors
has
not
been
definitely
established.
We
discovered
subpopulation
found
expression
C1ql1
,
gene
previously
described
for
its
synaptic
function
in
neurons.
This
starts
to
appear
during
first
postnatal
week
mouse
cortex.
Ablation
-expressing
leads
massive
lack
myelination
many
regions.
deficit
cannot
be
rescued,
even
though
some
escape
Sox10
-driven
ablation
end
up
partially
compensating
OPC
loss
adult.
Therefore,
molecular
marker
functionally
non-redundant
OPCs,
which
controls
myelinating
oligodendrocytes.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 30, 2025
Abstract
Oligodendrocyte
precursor
cells
(OPCs)
shape
brain
function
through
many
non-canonical
regulatory
mechanisms
beyond
myelination.
Here
we
show
that
OPCs
form
contacts
with
their
processes
on
neuronal
somata
in
a
activity-dependent
manner.
These
facilitate
exocytosis
of
lysosomes.
A
reduction
the
number
or
branching
reduces
these
contacts,
which
is
associated
lysosome
accumulation
and
altered
metabolism
neurons
more
senescent
age.
similar
OPC
seen
an
early-stage
mouse
model
Alzheimer’s
disease.
Our
findings
have
implications
for
prevention
age-related
pathologies
treatment
neurodegenerative
diseases.
