bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Дек. 12, 2023
Layer specific computations in the brain rely on neuronal processes establishing synaptic connections with partners distinct laminae. In
Язык: Английский
Nature, Год журнала: 2024, Номер 634(8032), С. 124 - 138
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
134
Nature, Год журнала: 2024, Номер 634(8032), С. 166 - 180
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
23
Nature, Год журнала: 2024, Номер 634(8032), С. 113 - 123
Опубликована: Окт. 2, 2024
Язык: Английский
Процитировано
8
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Окт. 13, 2023
A catalog of neuronal cell types has often been called a "parts list" the brain, and regarded as prerequisite for understanding brain function. In optic lobe
Язык: Английский
Процитировано
17
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Апрель 8, 2024
Abstract Normalization is a fundamental operation in image processing. Convolutional nets have evolved to include large number of normalizations (Ioffe and Szegedy 2015; Ulyanov, Vedaldi, Lempitsky 2016; Wu He 2018), this architectural shift has proved essential for robust computer vision (He et al. Bjorck 2018; Santurkar, Tsipras, Ilyas 2018). Studies biological vision, contrast, invoked just one or few model psychophysical (Mach 1868; Furman 1965; Sperling 1970) physiological (Carandini Heeger 2011; Shin Adesnik 2024) observations that accumulated over century. Here connectomic information (Matsliah 2023) used argue interneurons the fly visual system support with unprecedented specificity. Ten interneuron types distal medulla (Dm) optic lobe, example, appear chiefly spatial normalizations, each which specific single cell type length scale. Another Dm supports normalization features as well space. Two outlier do not at all. Interneuron likely be normalizers are identified only but also all other families lobe. For diversity appears an inevitable consequence specificity normalizations.
Язык: Английский
Процитировано
4
The Journal of Comparative Neurology, Год журнала: 2025, Номер 533(2)
Опубликована: Фев. 1, 2025
ABSTRACT Arthropods are diverse, abundant, successful animals that exploit all available ecological niches. They sense the environment, move, interact with prey/predators/conspecifics, learn, and so forth using small brains five orders of magnitude less neurons than mammals. Hence, these need to be efficient in information processing. One distinct aspect is presence large, easily identifiable single act as functional units for processing integrating a high volume from different sources guide behavior. To understand synaptic organization behind high‐integration nodes research on suitable needed. The lobula giant (LGs) found third optic neuropil, lobula, semiterrestrial crabs Neohelice granulata respond moving stimuli, integrate both eyes, show short‐ long‐term plasticity. thought key elements visuomotor transformation guiding escape responses approaching objects. subgroup, MLG1 (monostratified LG type 1), composed 16 have very wide main branches regular arrangement deep layer which allows their identification even unstained preparations. Here, we describe types abundance contacts involving profiles transmission electron microscopy (TEM). We an unexpected diversity motifs apparent compartmentalization dendritic arbor two domains where MLG1s predominantly presynaptic or postsynaptic, respectively. propose variety contact reflects multiple circuits cells involved. Regarding detection objects, distinctive input shared by locusts suggest similar collision‐detecting pathways species.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Март 15, 2025
Accumulating information is a critical component of most circuit computations in the brain across species, yet its precise implementation at synaptic level remains poorly understood. Dissecting such neural circuits vertebrates requires knowledge functional properties and ability to directly correlate dynamics with underlying wiring diagram same animal. Here we combine calcium imaging ultrastructural reconstruction, using visual motion accumulation paradigm larval zebrafish. Using connectomic analyses functionally identified cells computational modeling, show that bilateral inhibition, disinhibition, recurrent connectivity are prominent motifs for sensory within anterior hindbrain. We also demonstrate similar insights about structure-function relationship this can be obtained through complementary methods involving cell-specific morphological labeling via photo-conversion neuronal response types. used our unique ground truth datasets train test novel classifier algorithm, allowing us assign labels neurons from libraries where lacking. The resulting feature-rich library identities connectomes enabled constrain biophysically realistic network model hindbrain reproduce observed make testable predictions future experiments. Our work exemplifies power hypothesis-driven electron microscopy paired recordings gain mechanistic into signal processing provides framework dissecting vertebrates.
Язык: Английский
Процитировано
0
Developmental Cell, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Дек. 12, 2023
Layer specific computations in the brain rely on neuronal processes establishing synaptic connections with partners distinct laminae. In
Язык: Английский
Процитировано
1