Distinct Roles of Somatostatin and Parvalbumin Interneurons in Regulating Predictive Actions and Emotional Responses During Trace Eyeblink Conditioning DOI Creative Commons
Jiaman Dai, Qian‐Quan Sun

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Learning involves evaluating multiple dimensions of information and generating appropriate actions, yet how the brain assigns value to this remains unclear. In study, we show that two types interneurons (INs) in primary somatosensory cortex-somatostatin-expressing (SST-INs) parvalbumin-expressing (PV-INs) neurons-differentially contribute evaluation during trace eyeblink conditioning (TEC). An air puff (unconditioned stimulus, US) delivered after a whisker stimulus (conditioned CS) elicited both reflexive eye closure stress-related locomotion. However, only self-initiated, anticipatory CS window, measured via electromyography (EMG), was directly relevant learning performance. We found SST-IN activity changes aligned with induced blinks period, correlated EMG across learning. contrast, PV-IN positively locomotion following US showed no related changes, suggesting role processing emotional or aversive component task. Furthermore, cholinergic signaling nicotinic receptors modulated SST- activities, manner consistent their distinctive roles, linking these regulation learning-related actions responses, respectively. These findings demonstrate distinct interneuron populations evaluate different information-SST-INs for predictive, adaptive PV-INs responses-to guide behavior.

Язык: Английский

Inhibitory cell type heterogeneity in a spatially structured mean-field model of V1 DOI Creative Commons
Soon Ho Kim, Hannah Choi

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 13, 2025

Inhibitory interneurons in the cortex are classified into cell types differing their morphology, electrophysiology, and connectivity. Although it is known that parvalbumin (PV), somatostatin (SST), vasoactive intestinal polypeptide-expressing neurons (VIP), major inhibitory neuron subtypes cortex, have distinct modulatory effects on excitatory neurons, how heterogeneous spatial connectivity properties relate to network computations not well understood. Here, we study implications of dynamics spatially-structured neural networks. We develop a mean-field model system order systematically examine excitation-inhibition balance, dynamical stability, cell-type specific gain modulations. The incorporates three with probabilities recent evidence long-range projections SST neurons. Position-dependent firing rate predictions validated against simulations, balanced solutions under Gaussian assumptions derived from scaling arguments. Stability analysis shows while E-I circuits homogeneous population result instability, maintains stability projections. This suggests mixture short inhibitions may be key providing diverse maintaining stability. further find conductance-based synaptic transmissions necessary reproduce experimentally observed cell-type-specific modulations inhibition by PV mechanisms underlying changes elucidated using linear response theory. Our theoretical approach offers insight computational function distance-dependent structure.

Язык: Английский

Процитировано

0
Distinct Roles of Somatostatin and Parvalbumin Interneurons in Regulating Predictive Actions and Emotional Responses During Trace Eyeblink Conditioning DOI Creative Commons
Jiaman Dai, Qian‐Quan Sun

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Learning involves evaluating multiple dimensions of information and generating appropriate actions, yet how the brain assigns value to this remains unclear. In study, we show that two types interneurons (INs) in primary somatosensory cortex-somatostatin-expressing (SST-INs) parvalbumin-expressing (PV-INs) neurons-differentially contribute evaluation during trace eyeblink conditioning (TEC). An air puff (unconditioned stimulus, US) delivered after a whisker stimulus (conditioned CS) elicited both reflexive eye closure stress-related locomotion. However, only self-initiated, anticipatory CS window, measured via electromyography (EMG), was directly relevant learning performance. We found SST-IN activity changes aligned with induced blinks period, correlated EMG across learning. contrast, PV-IN positively locomotion following US showed no related changes, suggesting role processing emotional or aversive component task. Furthermore, cholinergic signaling nicotinic receptors modulated SST- activities, manner consistent their distinctive roles, linking these regulation learning-related actions responses, respectively. These findings demonstrate distinct interneuron populations evaluate different information-SST-INs for predictive, adaptive PV-INs responses-to guide behavior.

Язык: Английский

Процитировано

0