The visual system of the longest-living vertebrate, the Greenland shark DOI Creative Commons
Lily Fogg, Emily Tom, Maxime Policarpo

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Abstract The Greenland shark ( Somniosus microcephalus ) is the longest-living vertebrate and inhabits extremely dim cold waters of Arctic deep sea. This has led to speculations that it may have lost functional vision. Here, we present genomic, transcriptomic, histological evidence retains an intact visual system well-adapted for life in light. Histology vitro opsin expression revealed adaptations typical deep-sea species, including densely packed, elongated rods a short-wavelength shift rod pigment sensitivity. RNAscope confirmed presence essential cell types, such as rods, Müller glia, bipolar, amacrine, ganglion cells. Moreover, despite being centuries old, examined specimens showed no signs retinal degeneration. Using whole genome RNA-sequencing, further show dim-light (rod-based) vision genes are robustly expressed, while many bright-light (cone-based) become pseudogenized and/or longer expressed. Finally, our data suggest efficient DNA repair mechanisms contribute long-term preservation function over shark.

Язык: Английский

The visual system of the longest-living vertebrate, the Greenland shark DOI Creative Commons
Lily Fogg, Emily Tom, Maxime Policarpo

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Abstract The Greenland shark ( Somniosus microcephalus ) is the longest-living vertebrate and inhabits extremely dim cold waters of Arctic deep sea. This has led to speculations that it may have lost functional vision. Here, we present genomic, transcriptomic, histological evidence retains an intact visual system well-adapted for life in light. Histology vitro opsin expression revealed adaptations typical deep-sea species, including densely packed, elongated rods a short-wavelength shift rod pigment sensitivity. RNAscope confirmed presence essential cell types, such as rods, Müller glia, bipolar, amacrine, ganglion cells. Moreover, despite being centuries old, examined specimens showed no signs retinal degeneration. Using whole genome RNA-sequencing, further show dim-light (rod-based) vision genes are robustly expressed, while many bright-light (cone-based) become pseudogenized and/or longer expressed. Finally, our data suggest efficient DNA repair mechanisms contribute long-term preservation function over shark.

Язык: Английский

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