Review: Advances in the molecular neurobiology of posttraumatic stress disorder from global contexts: A systematic review of longitudinal studies — R0/PR2 DOI Creative Commons

Опубликована: Май 26, 2023

Trauma exposure is prevalent globally and a defining event for the development of posttraumatic stress disorder (PTSD), characterised by intrusive thoughts, avoidance behaviours, hypervigilance negative alterations in cognition mood. Exposure to trauma elicits range physiological responses which can interact with environmental factors confer relative risk or resilience PTSD. This systematic review summarises findings longitudinal studies examining biological correlates predictive PTSD symptomology. Databases (Pubmed, Scopus Web Science) were systematically searched using relevant keywords published between 1 January 2021 31 December 2022. English language included if they original research manuscripts meta-analyses cohort investigations that assessed relationships one more molecular-level measures either status symptoms. Eighteen 1,042 records identified included. Studies primarily military veterans/personnel, individuals admitted hospitals after acute traumatic injury, women exposed interpersonal violence rape. Genomic, inflammation endocrine most commonly molecular markers highlighted processes related inflammation, responding, learning memory. Quality assessments done Systematic Appraisal Observational Research, majority rated as being high quality, remainder moderate quality. predominantly conducted upper-income countries. Those performed low- middle-income countries not broadly representative terms demographic, type geographic profiles, three out four assessing only female participants, rape South Africa, respectively. They also did generate multimodal data use machine multilevel modelling, potentially reflecting greater resource limitations LMICs. Research contributions does adequately reflect global burden disorder.

Язык: Английский

Distinct saliva DNA methylation profiles in relation to treatment outcome in youth with posttraumatic stress disorder DOI Creative Commons
Judith B. M. Ensink, Peter Henneman,

Andrea Venema

и другие.

Translational Psychiatry, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 26, 2024

In youth with posttraumatic stress disorder (PTSD) non-response rates after treatment are often high. Epigenetic mechanisms such as DNA methylation (DNAm) have previously been linked to PTSD pathogenesis, additionally DNAm may affect response (psychological) therapies. Besides investigating the direct link between and response, it might be helpful investigate associated biological outcome. Thereby gaining a deeper molecular understanding of how psychotherapy (reflecting change in environment) relates epigenetic changes adaptability individuals. To date, limited research is done clinical samples no studies conducted youth. Therefore we study Dutch cohort without (n = 87, age 8-18 years). We examined cross-sectional longitudinal saliva-based genome-wide levels, salivary cortisol secretion. The last reflect possible abbreviations on hypothalamic-pituitary- adrenal (HPA) axis. HPA-axis development recovery PTSD. Youth were treated 8 sessions either Eye Movement Reprocessing Therapy (EMDR) or Trauma Focused Cognitive behavioral (TF-CBT). Our epigenome wide approach showed distinct responders non-responders C18orf63 gene post-treatment. This genomic region related PAX5 gene, involved neurodevelopment inflammation response. Additionally, our targeted indicated that there successfully at CRHR2 gene. Methylation this was further correlated secretion pre- Awaiting replication, findings first point pathways neuroplasticity

Язык: Английский

Процитировано

1
NETfacts: a community intervention integrating trauma treatment at the individual and collective level DOI Creative Commons

Anke Koebach,

Katy Robjant

European journal of psychotraumatology, Год журнала: 2021, Номер 12(1)

Опубликована: Янв. 1, 2021

The aim of this article is to present a research-based rationale for NETfacts, newly developed integrated approach at the individual and community level in order mitigate mental social sequelae war crisis. To end, we provide selective review relevant literature from neuroscience, clinical psychology, science. In psychotraumatology, avoidance describes effort prevent exposure trauma reminders. Among patients with post-traumatic stress disorder (PTSD), becomes pathological, exacerbating distress preventing recovery. This silence resonates traumatized communities consequently taboo builds - ultimately advantage perpetrators. resulting collective leads fragmented memory about or human rights violations so that shared account group's history impossible. deficient promotes ambiguous truths anxiety, enabling reactive construction safety based on information an endorsement extreme opinions. Ongoing insecurity, violence crime lead increasing anxiety fear. self-interest perpetrators abnormal behaviour survivors escalation stigma exclusion prevention limitation traumatic material, i.e., reduce tension protect safety. recognition facts subject key coherent sense communion, further cycles violence. NETfacts health system combines community-based intervention treat structure both levels. Abbreviations: NET: narrative therapy; FORNET: therapy forensic offender rehabilitation; NETfacts: derived therapy.El objetivo de este artículo es presentar una justificación basada en la investigación para NETfacts; un enfoque integrado recientemente desarrollado nivel y comunitario mitigar las secuelas mentales sociales guerra Con fin, proporcionamos revisión selectiva literatura relevante neurociencia, psicología clínica, ciencias sociales. En psicotraumatología, evitación describe el esfuerzo prevenir exposición recordatorios del trauma. Entre los pacientes con trastorno estrés postraumático (TEPT), se vuelve patológico, exacerbando angustia e impidiendo recuperación. Este silencio resuena comunidades traumatizadas y, consecuencia, construye como tabú, última instancia beneficio perpetradores. La evasión colectiva resultante conduce memoria fragmentada sobre o violaciones derechos humanos comunidad, por lo que relato compartido historia grupo imposible. deficiente promueve verdades ambiguas ansiedad, posibilitando construcción reactiva seguridad información al respaldo opiniones extremas. inseguridad, violencia delincuencia continuas provocan aumento ansiedad miedo. El interés propio perpetradores comportamiento anormal sobrevivientes escalada estigma exclusión resulta prevención limitación comunidad material traumático, decir, tensión protege seguridad. reconocimiento hechos traumáticos sujetos son claves coherente sentido comunión, nuevos ciclos violencia. sistema salud combina intervención comunitaria tratar estructura tanto colectivo.本文旨在 一种新开发的用以减轻战争和危机的心理和社会后遗症的个人和团体水平的综合方法, 提供基于研究的理论依据。为此, 我们对神经科学, 临床心理学和社会科学的相关文献进行了选择性回顾。在心理创伤学中, 个体回避描述了防止暴露于创伤提示物的努力。在创伤后应激障碍 (PTSD) 患者中, 这会变成病理性的, 加剧痛苦并阻止康复。这种沉默在遭受创伤的团体中引起共鸣, 从而产生了禁忌——最终对施暴者有利。由此产生的集体回避导致关于团体创伤或侵犯人权的集体记忆破碎, 因此无法实现群体历史的共享解释。不足的集体记忆会促进模糊事实和焦虑, 使基于选择性信息的安全反应构建成为可能, 从而导致产生极端观点。持续的不安全感, 暴力和犯罪导致焦虑和恐惧加剧。肇事者的私利和幸存者的异常行为导致污名化和社会排斥升级, 从而防止或限制团体接触创伤材料, 即减少紧张感并保护安全感建立。以回避为准的暴露和识别创伤性事实是连贯集体记忆和共享感, 并防止进一步暴力循环的关键。 健康系统结合了个人和团体干预措施, 以在个人和集体层面处理记忆结构。.

Процитировано

9
Unraveling epigenomic signatures and effectiveness of electroconvulsive therapy in treatment-resistant depression patients: a prospective longitudinal study DOI Creative Commons
Rosana Carvalho Silva, Paolo Martini, Christa Hohoff

и другие.

Clinical Epigenetics, Год журнала: 2024, Номер 16(1)

Опубликована: Июль 17, 2024

Abstract Background Electroconvulsive therapy (ECT) benefits patients with treatment-resistant depression (TRD), but the underlying biological processes are unclear. We conducted an epigenome-wide association study in 32 TRD undergoing ECT to depict ECT-associated methylation changes. Illness severity and outcomes were assessed Montgomery–Åsberg Depression Rating Scale at baseline (T0) 1 month after its end (T1). Methylation was profiled T0 T1 Illumina Infinium EPIC BeadChip array. Results Longitudinal T0–T1 analyses showed 3 differentially methylated probes (DMPs) nominal p values ≤ 10 −5 , 2 annotated genes CYB5B PVRL4 . Including covariates, we found 4 DMPs for symptoms variation, FAM20C EPB41 OTUB1 ADARB1 response status, IQCE Regional analysis revealed 54 regions (DMRs) value area 0.05, 9 presenting adjusted -value 0.10, MCF2L SLC25A24 RUNX3 MIR637 FOXK2 FAM180B POU6F1 ALS2CL CCRL2 Considering 21 DMRs variation 26 (nominal 0.05), 0.10 response, SNORD34 NLRP6 GALNT2 SFT2D3 None remained significant false discovery rate correction. Notably, variants associated suicide attempt psychiatric disorders, relates conduct disorder. Several inflammatory/immune processes. on females (n = 22) statistically (adjusted 0.05) trend-significant 0.07) related disorders ( ZFP57 POLD4, TRIM10, GAS7, ADORA2A, TOLLIP ), trauma exposure RIPOR2 ) responses LAT DLX4 POLD4 FAM30A, H19 ). Pathway enrichment transcriptional activity, growth factors, DNA maintenance, immune pathways including IRF7 IRF2 Conclusion Although no results whole cohort, provides insights into changes, highlighting outcomes. Analyses

Язык: Английский

Процитировано

0
Sex-stratified Genomic Structural Equation Models of Posttraumatic Stress Inform PTSD Etiology: L'utilisation de la modélisation génomique par équations structurelles stratifiée par sexe du stress post-traumatique pour expliquer l'étiologie du TSPT DOI Creative Commons
Ashley Moo-Choy, Dan J. Stein, Joel Gelernter

и другие.

The Canadian Journal of Psychiatry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Posttraumatic stress disorder (PTSD) affects 3.9%-5.6% of the worldwide population, with well-documented sex-related differences. While psychosocial and hormonal factors affecting sex differences in PTSD posttraumatic (PTS) symptom etiology have been explored, there has limited focus on genetic bases these Many combinations may confer a diagnosis. We hypothesized that sex-specific patterns, examination which could inform etiological genetics between males females.

Язык: Английский

Процитировано

0
Sex-stratified genomic structural equation models of posttraumatic stress inform PTSD etiology DOI Open Access
Ashley Moo-Choy, Murray B. Stein, Joel Gelernter

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Сен. 2, 2023

Posttraumatic stress disorder (PTSD) affects 3.9%-5.6% of the worldwide population, with well-documented sex-related differences. While psychosocial and hormonal factors affecting sex differences in PTSD posttraumatic (PTS) symptom etiology have been explored, there has limited focus on genetic bases these Many combinations may confer a diagnosis. We hypothesized that sex-specific patterns, examination which could inform etiological genetics between males females. To investigate this, we performed sex-stratified multivariate genome-wide association study (GWAS) unrelated UK Biobank (UKB) individuals European ancestry. Using GWAS summary data, genomic structural equation modeling was to generate factor models using six indicator variables: trouble concentrating, feeling distant from others, irritability, disturbing thoughts, upset feelings, avoidance places/activities remind individual traumatic event. Models male female symptoms differed substantially (local standardized root mean square difference=3.12) significantly (χ 2 (5)=28.03, p=3.6x10 -5 ). Independent two-factor best fit data both females; were subjected each sex, revealing three significant loci females, mapping SCAND3, WDPCP, FAM120A. No identified males. All four PTS (2 females) heritable (p<0.05): PTS-f 1 h -SNP=1.85%, -SNP=1.47%, -SNP=3.87%, -SNP=3.53%. Male enriched for medication-related putative causal relationships (3.73-fold, p=0.032) while body structure (2.84-fold, p=5.512x10 -7 ) cognitive (3.22-fold, p=0.009) relationships. In metabolic (28.08-fold, p=0.035). By assessing relationship symptoms, this informs correlative putatively females support further investigation genetics.

Язык: Английский

Процитировано

0
NEUROBIOLOGIA DOS EVENTOS ADVERSOS NA INFÂNCIA: UMA REVISÃO INTEGRATIVA DOI Open Access

Thuanne Carolline Silva Lima,

Analea Beatriz De Almeida Lira,

Beatriz Chaves Arruda da Silva

и другие.

Опубликована: Янв. 1, 2023

Процитировано

0
Decision: Advances in the molecular neurobiology of posttraumatic stress disorder from global contexts: A systematic review of longitudinal studies — R1/PR10 DOI Creative Commons
Jacqueline S. Womersley, Morne du Plessis,

M. Claire Greene

и другие.

Опубликована: Авг. 24, 2023

Trauma exposure is prevalent globally and a defining event for the development of posttraumatic stress disorder (PTSD), characterised by intrusive thoughts, avoidance behaviours, hypervigilance negative alterations in cognition mood. Exposure to trauma elicits range physiological responses which can interact with environmental factors confer relative risk or resilience PTSD. This systematic review summarises findings longitudinal studies examining biological correlates predictive PTSD symptomology. Databases (Pubmed, Scopus Web Science) were systematically searched using relevant keywords published between 1 January 2021 31 December 2022. English language included if they original research manuscripts meta-analyses cohort investigations that assessed relationships one more molecular-level measures either status symptoms. Eighteen 1,042 records identified included. Studies primarily military veterans/personnel, individuals admitted hospitals after acute traumatic injury, women exposed interpersonal violence rape. Genomic, inflammation endocrine most commonly molecular markers highlighted processes related inflammation, responding, learning memory. Quality assessments done Systematic Appraisal Observational Research, majority rated as being high quality, remainder moderate quality. predominantly conducted upper-income countries. Those performed low- middle-income countries not broadly representative terms demographic, type geographic profiles, three out four assessing only female participants, rape South Africa, respectively. They also did generate multimodal data use machine multilevel modelling, potentially reflecting greater resource limitations LMICs. Research contributions does adequately reflect global burden disorder.

Язык: Английский

Процитировано

0
Recommendation: Advances in the molecular neurobiology of posttraumatic stress disorder from global contexts: A systematic review of longitudinal studies — R1/PR9 DOI Creative Commons
Jacqueline S. Womersley, Morne du Plessis, M. Claire Greene

и другие.

Опубликована: Авг. 24, 2023

Trauma exposure is prevalent globally and a defining event for the development of posttraumatic stress disorder (PTSD), characterised by intrusive thoughts, avoidance behaviours, hypervigilance negative alterations in cognition mood. Exposure to trauma elicits range physiological responses which can interact with environmental factors confer relative risk or resilience PTSD. This systematic review summarises findings longitudinal studies examining biological correlates predictive PTSD symptomology. Databases (Pubmed, Scopus Web Science) were systematically searched using relevant keywords published between 1 January 2021 31 December 2022. English language included if they original research manuscripts meta-analyses cohort investigations that assessed relationships one more molecular-level measures either status symptoms. Eighteen 1,042 records identified included. Studies primarily military veterans/personnel, individuals admitted hospitals after acute traumatic injury, women exposed interpersonal violence rape. Genomic, inflammation endocrine most commonly molecular markers highlighted processes related inflammation, responding, learning memory. Quality assessments done Systematic Appraisal Observational Research, majority rated as being high quality, remainder moderate quality. predominantly conducted upper-income countries. Those performed low- middle-income countries not broadly representative terms demographic, type geographic profiles, three out four assessing only female participants, rape South Africa, respectively. They also did generate multimodal data use machine multilevel modelling, potentially reflecting greater resource limitations LMICs. Research contributions does adequately reflect global burden disorder.

Язык: Английский

Процитировано

0
Review: Advances in the molecular neurobiology of posttraumatic stress disorder from global contexts: A systematic review of longitudinal studies — R1/PR8 DOI Creative Commons
Jacqueline S. Womersley, Morne du Plessis, M. Claire Greene

и другие.

Опубликована: Авг. 23, 2023

Trauma exposure is prevalent globally and a defining event for the development of posttraumatic stress disorder (PTSD), characterised by intrusive thoughts, avoidance behaviours, hypervigilance negative alterations in cognition mood. Exposure to trauma elicits range physiological responses which can interact with environmental factors confer relative risk or resilience PTSD. This systematic review summarises findings longitudinal studies examining biological correlates predictive PTSD symptomology. Databases (Pubmed, Scopus Web Science) were systematically searched using relevant keywords published between 1 January 2021 31 December 2022. English language included if they original research manuscripts meta-analyses cohort investigations that assessed relationships one more molecular-level measures either status symptoms. Eighteen 1,042 records identified included. Studies primarily military veterans/personnel, individuals admitted hospitals after acute traumatic injury, women exposed interpersonal violence rape. Genomic, inflammation endocrine most commonly molecular markers highlighted processes related inflammation, responding, learning memory. Quality assessments done Systematic Appraisal Observational Research, majority rated as being high quality, remainder moderate quality. predominantly conducted upper-income countries. Those performed low- middle-income countries not broadly representative terms demographic, type geographic profiles, three out four assessing only female participants, rape South Africa, respectively. They also did generate multimodal data use machine multilevel modelling, potentially reflecting greater resource limitations LMICs. Research contributions does adequately reflect global burden disorder.

Язык: Английский

Процитировано

0
Review: Advances in the molecular neurobiology of posttraumatic stress disorder from global contexts: A systematic review of longitudinal studies — R1/PR7 DOI Creative Commons
Jacqueline S. Womersley, Morne du Plessis, M. Claire Greene

и другие.

Опубликована: Авг. 8, 2023

Trauma exposure is prevalent globally and a defining event for the development of posttraumatic stress disorder (PTSD), characterised by intrusive thoughts, avoidance behaviours, hypervigilance negative alterations in cognition mood. Exposure to trauma elicits range physiological responses which can interact with environmental factors confer relative risk or resilience PTSD. This systematic review summarises findings longitudinal studies examining biological correlates predictive PTSD symptomology. Databases (Pubmed, Scopus Web Science) were systematically searched using relevant keywords published between 1 January 2021 31 December 2022. English language included if they original research manuscripts meta-analyses cohort investigations that assessed relationships one more molecular-level measures either status symptoms. Eighteen 1,042 records identified included. Studies primarily military veterans/personnel, individuals admitted hospitals after acute traumatic injury, women exposed interpersonal violence rape. Genomic, inflammation endocrine most commonly molecular markers highlighted processes related inflammation, responding, learning memory. Quality assessments done Systematic Appraisal Observational Research, majority rated as being high quality, remainder moderate quality. predominantly conducted upper-income countries. Those performed low- middle-income countries not broadly representative terms demographic, type geographic profiles, three out four assessing only female participants, rape South Africa, respectively. They also did generate multimodal data use machine multilevel modelling, potentially reflecting greater resource limitations LMICs. Research contributions does adequately reflect global burden disorder.

Язык: Английский

Процитировано

0