Mental health in Germany before, during and after the COVID-19 pandemic

PLoS ONE, Год журнала: 2025, Номер 20(1), С. e0313689 - e0313689

Опубликована: Янв. 3, 2025

Based on nationally representative panel data (N person-years = 40,020; N persons 18,704; Panel Labour Market and Social Security; PASS) from 2018 to 2022, we investigate how mental health changed during after the COVID-19 pandemic. We employ time-distributed fixed effects regressions show that (Mental Health Component Summary Score of SF-12) decreased first wave in 2020 onward, leading most pronounced decreases Delta wave, which began August 2021. In summer had not returned baseline levels. An analysis subdomains measure indicates long-term negative changes are mainly driven by declines psychological well-being calmness. Furthermore, our results indicate no clear patterns heterogeneity between age groups, sex, income, education, migrant status, childcare responsibilities or pre-COVID-19 status. Thus, pandemic appears have a uniform effect German adult population did lead widening inequalities long run.

Язык: Английский

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Polycrisis, Emotional Regulation, Personality Traits, and Well-Being of Young People Entering Adulthood

Social Indicators Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 4, 2025

Despite substantial investments in mental health care and healthcare accessibility Europe, the well-being of young people is on a concerning decline. This deterioration further exacerbated by recent global crises, notably Covid-19 pandemic, war Ukraine, climate change, deepening economic crisis leading to increased poverty social exclusion. The main research goal was investigate how entering adulthood experience polycrisis stress, responsibility for self-perceived proximity. study involved 403 adult Poles, taking high school final exams years 2020–21. Assessment tools included Brief Symptoms Inventory 18, Difficulties Emotion Regulation Scale, Personality ICD-11, Flourishing Index. Using latent class analysis, three distinct profiles were identified, representing diverse experiences polycrisis. Group 1 primarily experienced stress related crisis, reported lower depression rates maintained relatively stable well-being. 2 confronted various aspects polycrisis, excluding COVID-19, carried strong sense while experiencing emotional challenges. 3 full spectrum showing tendencies towards perfectionism rule rigidity, without specific problems. findings this provide valuable insights developing models adults' post-crisis functioning designing early, targeted interventions. Clinical Trial: clinical trial identifier NCT05930652.

Язык: Английский

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Activation of glutamine synthetase (GS) as a new strategy for the treatment of major depressive disorder and other GS-related diseases

Acta Pharmacologica Sinica, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Glutamine synthetase (GS) plays a crucial role in the homeostasis of glutamate–glutamine cycle brain. Hypoactive GS causes depressive behaviors. Under chronic stress, has no change expression, but its activity is decreased due to nitration tyrosine (Tyr). Thus, we speculate that agents prevent or facilitate denitration would be candidates for new antidepressants. Using human recombinant and mouse lysate from medial prefrontal cortex, demonstrated Tyr (0.0313−0.5 µM) dose-dependently protected against peroxynitrite-induced Tyr-nitration GS. Diet supplementation with exerted significant antidepressant effects immobilization stress depression model. We further found dipeptides, such as tyrosyl-glutamine (YQ), had appropriate chemical properties medication also increased both vitro vivo effects. Because reduced occurs epilepsy hyperammonemia, evaluated whether YQ therapeutic Interestingly, administration significantly attenuated kainic acid-induced seizures mice blood ammonia levels azoxymethane- bile duct ligation-induced hyperammonemia models, which was accompanied by an increment activity. The activation accomplished decrement Tyr-nitration, so-called Tyr-denitration. Therefore, this study demonstrates could strategy treat other GS-related diseases.

Язык: Английский

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Trends in psychological distress during and after the COVID-19 pandemic: Findings from a population-based Costa Rican cohort study

Public Health, Год журнала: 2025, Номер 240, С. 88 - 94

Опубликована: Янв. 29, 2025

Язык: Английский

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Unmasking the psychological impact of the early COVID-19 pandemic in young adults: results from a cross-sectional online survey

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Март 6, 2025

The COVID-19 pandemic emerged as an international public health emergency and threat to individual psychological resilience. To examine the prevalence of issues identify key associations with mental indicators in young adults (ages 18-28) worldwide during initial phase pandemic. Through a cross-sectional online survey utilizing convenience sampling, we collected data on demographics, COVID-19-related questions, depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), stress/trauma (Impact Event Scale-Revised), fear (Fear scale) between September 2020-January 2021. A total 183 were eligible analysis. All statistical analyses set at alpha = 0.05. Over 70% participants reported mild (n=129), 80% (n=136), 40% pandemic-related trauma (n=61), 50% high (n=88). Female respondents higher (t(173)=-3.352, <.001), (t(166)=-3.310, P=.001), from ((t(151)=-2.004, P=.047). Hispanic/Latino/a/x (F(2,156)=7.761, P<.001) scores (F(2,143)=3.999, P=.020). Age 2020 was associated (F(1,154)=4.230, P=0.041, R2 0.027). Individuals who mandated quarantine linked lower levels (F(2,175)=3.442, P=.034) (F(2,170)=3.092, P =.048) than those not mandated. Those quarantined close contacts (t(162.184)=2.705, =.008) (t(149)=2.169; P=.032). Close contacts' hospitalization infections (t(127)=2.855, P=.005), depression(t(123)=3.111, P=.002), (t(152)=-1.975, P=.050). findings highlight significant effect had worldwide.

Язык: Английский

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Antiviral potential of bio-oil from Citrus sinensis waste wood as a therapeutic approach against COVID-19

Journal of Cleaner Production, Год журнала: 2024, Номер 447, С. 141583 - 141583

Опубликована: Март 1, 2024

Язык: Английский

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Clarifying the Links between Perceived Stress and Depressiveness: a Longitudinal Study of COVID-19’s Effects on Adolescents in Germany

Journal of Youth and Adolescence, Год журнала: 2024, Номер 53(10), С. 1 - 15

Опубликована: Май 24, 2024

Young people are navigating an increasingly uncertain and unstable social economic environment, further complicated by COVID-19. Individual resources vulnerabilities, such as mental health sensitivity to stress, play a significant role in how well youth adapt the career paths living conditions altered pandemic, dynamic that is not yet understood. This study examined of COVID-19 on intertwined relation between perceived stress depressiveness (negative positive affect) adolescents, focusing gender differences. Longitudinal data from 673 German adolescents (M

Язык: Английский

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Amplified psychological reaction to civil unrest among Holocaust survivor descendants

Stress and Health, Год журнала: 2024, Номер unknown

Опубликована: Июнь 15, 2024

Abstract The evidence regarding the intergenerational effects of Holocaust points to a heightened sensitivity traumatic and stressful events, as well threats. These were found across at least three generations: survivors themselves, their children, grandchildren. More specifically, this is manifested in increased psychological reactions adverse circumstances, especially when such situations trigger associations with Holocaust. During 2023 Israel has experienced unprecedented civil unrest protests following government's plan promote judicial overhaul. Many expressed fears for Israeli democracy integrity social fabric Israel. current study examined how descendants (i.e., children grandchildren survivors) prolonged unrest. A web‐based random sample 706 Jews born after World War II completed questionnaires several months before began (Wave 1, 2022) seven into 2, 2023). Supporting most our hypotheses, reported higher salience more preoccupation political upheaval) relative comparison those not directly exposed Holocaust). Relative descendants, also greater risk reporting exacerbation anxiety since overhaul was introduced, but depression or somatisation symptoms. Results remained significant controlling Wave 1 distress level, background characteristics, level engagement unrest, participants' viewpoint on findings further corroborate unique stress among time by highlighting during period turmoil.

Язык: Английский

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Prevalence of anxiety, depression and post-traumatic stress disorder symptoms in children and adolescents during the COVID-19 pandemic: A systematic review and meta-analysis

Journal of Public Health, Год журнала: 2023, Номер unknown

Опубликована: Дек. 29, 2023

Язык: Английский

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Young adults’ perceptions of information on social distancing measures and everyday life during the COVID-19 pandemic in Denmark and Sweden: an interview study

International Journal of Adolescence and Youth, Год журнала: 2024, Номер 29(1)

Опубликована: Фев. 7, 2024

With the outbreak of COVID-19 pandemic, Denmark and Sweden’s governments health authorities implemented social distancing measures as main strategy to limit spread coronavirus. In Denmark, these were mostly mandatory, whereas in Sweden they primarily voluntarily based. The aim this study was explore how young adults retrieved perceived information during pandemic what their experiences everyday life with measures. To end, 30 Danish Swedish between 18 25 years interviewed. participants considered themselves informed reflected on multiple sources information. However, translated different ways had both negative positive implications for lives. Many felt that youth – a significant phase became restricted.

Язык: Английский

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