Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7091 - 7091
Опубликована: Ноя. 23, 2024
Sleep
bruxism
(SB)
and
sleep-disordered
breathing
(SDB)
are
two
prevalent
conditions
that
significantly
impact
overall
health.
Studies
suggest
up
to
49.7%
of
individuals
with
SDB
also
exhibit
symptoms
SB.
This
review
aims
provide
a
comprehensive
analysis
the
role
genetic
background
neurotransmission
in
pathogenesis
co-occurrence
SB
SDB.
It
seeks
synthesize
current
knowledge,
highlight
gaps
existing
literature,
propose
new
perspective
integrates
neurobiological
factors.
shows
both
may
be
influenced
by
combination
genetic,
neurochemical,
environmental
factors
contribute
their
shared
pathophysiology.
The
key
neurotransmitters—dopamine,
serotonin,
GABA—may
play
significant
regulating
motor
activity,
sleep
architecture,
respiratory
control.
Understanding
neurochemical
mechanisms
allow
for
more
precise
diagnostic
tools
personalized
treatment
approaches
regarding
Clinically,
there
is
need
interdisciplinary
collaboration
between
specialists,
dentists,
neurologists,
geneticists.
There
conduct
large-scale
studies,
coupled
neuroimaging
neurophysiological
research,
uncovering
additional
insights
into
International Dental Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
To
investigate
the
prevalence
of
sleep
bruxism
(SB)
in
Thai
obstructive
apnea
(OSA)
patients
and
to
identify
demographic
characteristics
specific
parameters
associated
with
SB.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 29, 2024
Abstract
Background
Sleep
apnea
is
a
common
sleep
disorder
affecting
at
least
ten
percent
of
the
population.
It
caused
by
lack
breathing
during
sleep,
typically
mediated
obstruction
airways
or
less
frequently
misdirected
central
signals
for
breathing.
The
primary
risk
factor
high
body
mass
index
(BMI),
causing
airway
obstruction.
However,
understanding
factors
in
non-obese
(BMI
<
30)
individuals
requires
further
exploration.
Aim
Our
goal
was
to
elucidate
genetic
individuals.
Methods
We
performed
genome-wide
association
testing
with
BMI
30
FinnGen
including
20,413
cases
diagnosis
(ICD-10
G47.3
ICD-9
3472)
and
443,463
disease
free
controls.
replicated
our
analysis
Estonian
Biobank.
Results
identified
significant
within
Serotonin
receptor
1F
(
HTR1F
)
locus
(rs1818163,
beta
=
0.059,
se
0.010,
P
1.58e-8),
Biobank
(beta
=0.042,
0.021,
0.046).
signal
co-localized
expression
across
multiple
tissues
(posterior
probability
>
0.8),
single
cell
sequencing
implicated
particularly
neurons.
Analysis
eQTL
data
supported
possible
regulatory
role
neurons
-0.03,
1.2e-4).
Finally,
objectively
measured
sleep-activity
showed
number
awakenings
night
(P
5.6e-8).
Conclusions
findings
indicate
patient
population
range
provide
insight
into
growing
evidence
serotonin
signaling
as
modulating
liability
apnea.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 8, 2024
Background
Pichia
pastoris
-secreted
delta
sleep
inducing
peptide
and
crossing
the
blood-brain
barrier
peptides
(DSIP-CBBBP)
fusion
holds
significant
promise
for
its
potential
sleep-enhancing
neurotransmitter
balancing
effects.
This
study
investigates
these
properties
using
a
p-chlorophenylalanine
(PCPA)
-induced
insomnia
model
in
mice,
an
approach
akin
to
traditional
methods
evaluating
sleep-promoting
activities
peptides.
Aim
of
The
research
aims
elucidate
mechanism
DSIP-CBBBP,
exploring
impact
on
levels
regulation,
analyze
composition
structure.
Materials
Using
PCPA-induced
mouse
model,
evaluates
effects
DSIP-CBBBP.
peptide’s
influence
neurotransmitters
such
as
5-HT,
glutamate,
dopamine,
melatonin
is
assessed.
functions
DSIP-CBBBP
are
characterized
biochemical
animal
insomnia-induced
behavior
tests
compared
without
CBBBP.
Results
demonstrates
capacity
modulate
levels,
indicated
by
changes
DA,
melatonin.
shows
better
restorative
effect
than
DSIP
imbalance
enhance
sleep.
Conclusion
underscores
correcting
dysregulation
promoting
sleep,
hinting
at
utility
sleep-related
therapies.
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3580 - 3580
Опубликована: Окт. 22, 2024
Probiotics,
particularly
those
native
to
the
gut
microbiota,
have
a
profound
influence
on
environment.
In
this
study,
we
conducted
randomized
placebo-controlled,
double-blind,
parallel-group
comparison
trial
investigate
effects
of
Bifidobacterium
longum
BB536
(B.
BB536)
fecal
microbiota
and
metabolite
compositions
in
healthy
individuals.
We
compared
fermented
milk
produced
solely
with
Streptococcus
thermophiles
Lactobacillus
bulgaricus
(placebo
group)
supplemented
B.
(BY
group).
Our
findings
revealed
significantly
greater
relative
abundance
Faecalibacterium
BY
group
than
placebo
by
3rd
day,
trend
that
persisted
until
end
17th
day.
Additionally,
presented
increased
concentrations
tryptophan
(Trp),
Indole-3-lactic
acid,
Indole-3-aldehyde
A
significant
positive
correlation
was
observed
between
number
viable
bacteria
feces.
The
Trp
Indole-3-acetic
acid
were
also
correlated
results
suggest
intake
can
modulate
profiles,
which
are
general
indicators
for
monitoring
environment,
potentially
conferring
health
benefits
host.
Journal of Prosthodontics,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Abstract
Sleep‐related
bruxism
(SRB)
is
a
motor
oral
behavior
characterized
by
tooth
grinding
and
jaw
clenching
activity,
reported
8%–12%
of
the
adult
general
population
3%
older
individuals.
The
frequency
one
its
biomarkers,
rhythmic
masticatory
muscle
activity
(RMMA),
remains
elevated
across
ages.
Obstructive
sleep
apnea
(OSA)
associated
with
brief
repetitive
pause
breathing
(apnea)
transient
reduction
in
oxygen
(hypoxia).
OSA
observed
at
all
ages
about
50%
individuals
male
preponderance.
SRB
clinical
assessment
based
on
self‐reporting
sound,
awareness
clenching,
pain
or
headache,
observation
damage.
sleepiness
fatigue,
snoring,
quality,
cessation,
plus
examination
anatomical
factors
(e.g.,
obesity,
retrognathia,
large
tonsil,
macroglossia),
age,
gender,
body
mass.
Although
literature
does
not
support
association
causality
between
these
two
conditions,
co‐occurrence
30%–50%
adults.
To
confirm
diagnosis
co‐occurring
OSA,
home
testing
(HST)
may
be
indicated.
A
test
performed
using
electromyography
(EMG)
(masseter
temporalis)
cardio‐respiratory
variables
air
flow,
respiratory
effort,
level,
heart
rate).
management
for
prosthodontic
needs
challenging
to
prevent
compromising
oro‐pharyngeal
space
efficiency.
treatment
presence
includes
continuous
positive
airway
pressure
(CPAP)
use
alone
an
occlusal
splint
mandibular
advancement
device
(MAD).
In
addition,
following
considered:
supine
correction
device,
myofuncional
therapy,
medications,
surgeries.
All
have
limitations
risks.
Individual
variability
suggests
that
phenotyping
mandatory
select
most
efficient
personalized
treatment.
Frontiers in Psychiatry,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 5, 2024
Objective
Observational
studies
have
frequently
shown
a
co-occurrence
of
psychiatric
disorders
and
Obstructive
sleep
apnea
(OSA),
with
major
depressive
disorder
(MDD)
being
prevalent
disorder.
This
study
aims
to
investigate
the
genetic
overlap
between
MDD
OSA
explore
their
underlying
pathological
mechanisms.
Methods
Leveraging
extensive
recent
GWAS
for
MDD,
we
conducted
correlation
analyses
utilizing
Linkage
disequilibrium
score
regression
(LDSC),
re-evaluated
pleiotropic
Single-nucleotide
polymorphisms
(SNP)
Cross-Phenotype
Association
(CPASSOC)
Colocalization
(COLOC),
investigated
at
gene
level
using
physical
annotations
Multi-marker
Analysis
GenoMic
Annotation
(MAGMA),
finally
employed
Mendelian
randomization
(MR)
assess
potential
causal
relationships
two
disorders.
Results
Upon
our
investigation,
established
that
exhibit
high
heritability
(h2MDD=0.02,
h2OSA=0.04)
alongside
significant
(rg=0.31,
P=
1.42E-23).
Utilizing
CPASSOC,
identified
397
SNPs,
associable
45
loci,
which
share
common
fragments
role.
Furthermore,
MAGMA
uncovered
total
154
genes
capable
influencing
multiple
brain
regions.
Lastly,
leveraging
MR
analysis,
concluded
heightens
risk
developing
(P=3.
10E-04,
OR
(95%CI):1.28(1.12~
1.47)).
Conclusion
In
summary,
PCLO
as
provided
evidence
causally
contributes
development
OSA.
These
insights
enhance
understanding
shared
mechanisms
comorbidity
these
conditions.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7091 - 7091
Опубликована: Ноя. 23, 2024
Sleep
bruxism
(SB)
and
sleep-disordered
breathing
(SDB)
are
two
prevalent
conditions
that
significantly
impact
overall
health.
Studies
suggest
up
to
49.7%
of
individuals
with
SDB
also
exhibit
symptoms
SB.
This
review
aims
provide
a
comprehensive
analysis
the
role
genetic
background
neurotransmission
in
pathogenesis
co-occurrence
SB
SDB.
It
seeks
synthesize
current
knowledge,
highlight
gaps
existing
literature,
propose
new
perspective
integrates
neurobiological
factors.
shows
both
may
be
influenced
by
combination
genetic,
neurochemical,
environmental
factors
contribute
their
shared
pathophysiology.
The
key
neurotransmitters—dopamine,
serotonin,
GABA—may
play
significant
regulating
motor
activity,
sleep
architecture,
respiratory
control.
Understanding
neurochemical
mechanisms
allow
for
more
precise
diagnostic
tools
personalized
treatment
approaches
regarding
Clinically,
there
is
need
interdisciplinary
collaboration
between
specialists,
dentists,
neurologists,
geneticists.
There
conduct
large-scale
studies,
coupled
neuroimaging
neurophysiological
research,
uncovering
additional
insights
into
