Metabolomics identifies plasma biomarkers of localized radiation injury
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 16, 2025
A
radiological
accident
may
result
in
the
development
of
a
local
skin
radiation
injury
(LRI)
which
evolve,
depending
on
dose,
from
dry
desquamation
to
deep
ulceration
and
necrosis
through
unpredictable
inflammatory
waves.
Therefore,
early
diagnosis
victims
LRI
is
crucial
for
improving
medical
care
efficiency.
This
preclinical
study
aims
identify
circulating
metabolites
as
biomarkers
associated
with
using
C57BL/6J
mouse
model
hind
limb
irradiation.
More
precisely,
two
independent
mice
cohorts
were
used
conduct
broad-spectrum
profiling
followed
by
suspect
screening
analysis
performed
plasma
mass
spectrometry.
An
integrative
was
conducted
multi-block
sparse
partial
least
square
discriminant
(sPLS-DA)
establish
multi-scale
correlations
between
specific
levels
biological,
physiological
(injury
severity),
functional
parameters
(skin
perfusion).
The
identified
biomarker
signature
consists
6-metabolite
panel
including
putrescine,
uracil,
2,3-dihydroxybenzoate,
3-hydroxybenzoate,
L-alanine
pyroglutamate,
that
can
discriminate
according
dose
severity.
Our
results
demonstrate
relevant
molecular
support
use
suitable
prognosis
diagnosis.
Язык: Английский
A lectin affinity plasmapheresis device removes extracellular vesicles and microRNAs from renal perfusates following controlled oxygenated rewarming of discarded donor kidneys
Rosalia de Necochea Campion,
Miguel Pesqueira,
Paul Vallejos
и другие.
Transplant Immunology,
Год журнала:
2025,
Номер
unknown, С. 102215 - 102215
Опубликована: Фев. 1, 2025
Язык: Английский
Radiation-induced gastrointestinal and cutaneous injuries: understanding models, pathologies, assessments, and clinically accepted practices
International Journal of Radiation Biology,
Год журнала:
2024,
Номер
100(7), С. 969 - 981
Опубликована: Май 24, 2024
Purpose
A
U.
S.
and
European
joint
effort
fostering
the
development
of
medical
countermeasures
(MCMs)
operable
in
case
radiological
or
nuclear
emergencies.
Язык: Английский
The Hemopurifier removes extracellular vesicles and microRNAs from renal perfusates following controlled oxygenated rewarming of discarded donor kidneys
Rosalia de Necochea Campion,
Miguel Pesqueira,
Paul Vallejos
и другие.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 24, 2024
Abstract
Kidney
transplantation
is
considered
the
benchmark
treatment
for
end-stage
kidney
disease
patients.
Nevertheless,
demand
donor
kidneys
continuously
on
rise
and
scarcity
of
suitable
poses
a
significant
hindrance
patients
healthcare
providers.
One
approach
to
extend
criteria
use
from
deceased
brain
death
circulatory
donors.
Use
these
organs
especially
extended
donors
associated
with
ischemia
reperfusion
injury
(IRI)
resultant
delayed
graft
function
(DGF)
as
well
increased
rates
allograft
rejection.
try
lessen
complications
increase
time
assessment
organ
viability
machine
perfusion
recovered
kidneys.
In
this
study
we
obtained
perfusates
discarded
that
had
undergone
Controlled
Oxygenated
Rewarming.
Perfusates
were
analyzed
extracellular
vesicles
(EVs),
dsDNA
EVs
microRNAs.
These
then
pumped
over
Aethlon
Hemopurifier,
plasma
separator
an
affinity
resin
containing
lectin
Galanthus
nivalis
agglutinin
(GNA).
Following
diminution
in
vesicles,
microRNAs
was
observed.
results
support
future
Hemopurifier
part
circuit
explore
if
device
decreases
mediators
dynamic
improved
retrieved
Язык: Английский
Les micro-ARN comme biomarqueurs des lésions radio-induites
médecine/sciences,
Год журнала:
2024,
Номер
40(8-9), С. 634 - 642
Опубликована: Авг. 1, 2024
En
cas
d’urgence
radiologique
ou
nucléaire
résultant
d’un
accident
acte
de
malveillance,
la
prise
en
charge
médicale
requiert
l’identification
et
le
diagnostic
des
individus
exposés
à
fortes
doses
rayonnements
ionisants
plus
rapidement
possible.
Bien
qu’un
triage
préliminaire
puisse
être
effectué
directement
sur
terrain,
une
analyse
complémentaire
laboratoire
est
nécessaire
pour
affiner
diagnostic.
Les
techniques
actuellement
utilisées
limitent
rapide
simultanée
nombreux
patients.
Afin
pallier
ces
contraintes,
l’utilisation
nouveaux
biomarqueurs
prédire
risque
gravité
lésions
radio-induites
l’étude.
Dans
cette
revue,
nous
abordons
potentiel
micro-ARN
comme
pronostic
leur
pertinence
utilisation
radioprotection
chez
l’homme.