Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Июнь 5, 2024
Abstract
We
aimed
to
characterize
the
cognitive
profile
of
post-acute
COVID-19
syndrome
(PACS)
patients
with
complaints,
exploring
influence
biological
and
psychological
factors.
Participants
confirmed
SARS-CoV-2
infection
complaints
≥
8
weeks
phase
were
included.
A
comprehensive
neuropsychological
battery
(NPS)
health
questionnaires
administered
at
inclusion
1,
3
6
months.
Blood
samples
collected
each
visit,
MRI
scan
baseline
months,
and,
optionally,
cerebrospinal
fluid.
Cognitive
features
analyzed
in
relation
clinical,
neuroimaging,
biochemical
markers
follow-up.
Forty-nine
participants,
a
mean
time
from
symptom
onset
10.4
showed
attention-executive
function
(69%)
verbal
memory
(39%)
impairment.
Apathy
(64%),
moderate-severe
anxiety
(57%),
severe
fatigue
(35%)
prevalent.
Visual
(8%)
correlated
total
gray
matter
(GM)
subcortical
GM
volume.
Neuronal
damage
inflammation
within
normal
limits.
Over
time,
test
scores,
depression,
apathy,
indexes,
fluid
biomarkers
remained
stable,
although
fewer
participants
(50%
vs.
75.5%;
p
=
0.012)
exhibited
abnormal
evaluations
Altered
attention/executive
memory,
common
PACS,
persisted
most
subjects
without
association
structural
abnormalities,
elevated
cytokines,
or
neuronal
markers.
Nature and Science of Sleep,
Год журнала:
2025,
Номер
Volume 17, С. 97 - 113
Опубликована: Янв. 1, 2025
COVID-19
has
led
to
reports
of
fatigue
and
sleep
problems.
Brain
function
changes
underlying
problems
(SP)
post-COVID-19
are
unclear.
This
study
investigated
SP-related
brain
functional
connectivity
(FC)
alterations.
Fifty-five
survivors
with
SP
(COVID_SP)
33
without
(COVID_NSP),
matched
for
demographics,
completed
PSQI
underwent
rs-fMRI
at
baseline
2-month
follow-up.
Correlations
between
FC
clinical
data
were
analyzed
by
Pearson
correlation
analysis
Gaussian
random
field
(GRF)
correction.
The
repeated-measures
variance
(R-M
ANOVA)
was
explore
the
interaction
time.
At
baseline,
COVID_SP
exhibited
elevated
FC:
right
precentral
gyrus
(PrG)
left
lateral
occipital
cortex
(LOcC)/right
PrG,
inferior
parietal
lobule
(IPL)
superior
frontal
(SFG),
hippocampus
(IFG).
Higher
SFG
correlated
scores.
follow-up,
decreased
implicated
in
emotion
regulation,
executive
function,
memory;
increased
semantics,
attention,
auditory-visual
processing.
these
regions
scores
PSQI,
GAD,
PHQ.
Repeated-Measures
Analysis
Variance
revealed
a
significant
time
effect
various
scales.
Moreover,
PrG
as
well
that
IPL
also
discovered
effect.
provides
insight
into
associated
after
COVID-19.
These
may
partially
explain
development
SP,
they
changed
over
Psychiatry and Clinical Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Up
to
10%
of
SARS-CoV-2
infected
individuals
suffer
from
post-COVID-19
condition,
marked
by
fatigue
and
cognitive
dysfunction
as
major
symptoms.
Longitudinal
studies
on
neuropsychological
clinical
trajectories
related
brain
changes
are
scarce.
Here,
we
aimed
examine
their
evolution
up
2
years
post-infection.
In
a
multi-center,
longitudinal
study
79
post-COVID
patients
(mean
age
46,
48
female)
with
persistent
symptoms
21
age-
sex-matched
never-infected,
healthy
controls
42,
eight
female),
analyzed
performance,
self-reported
outcomes
associated
neuroimaging
alterations
resting-state
functional
structural
magnetic
resonance
imaging
data
23
months
after
infection
observed
(1)
that
severity
had
reduced
but
still
remained
present
in
most
patients,
(2)
widespread
involving
the
brainstem,
pre-
postcentral
gyrus
limbic
olfactory
network,
(3)
weakening
its
cerebral
associations.
Notably,
findings
aberrations
were
more
pronounced
hospitalized
patients.
Our
indicate
complex
adaptations
take
place
following
infection.
Some
regions
manifest
enduring
abnormalities
while
others
undergo
restitution.
The
attenuation
radio-clinical
associations
suggests
compensatory
function
for
these
regions,
pointing
non-brain
intrinsic
factors
sustain
fatigue.
Revista de Neurología,
Год журнала:
2025,
Номер
79(12)
Опубликована: Янв. 24, 2025
Introduction:
Long
COVID
is
defined
by
National
Institute
for
Health
and
Care
Excellence
(NICE)
as
the
set
of
signs
symptoms
that
develop
during
or
after
a
SARS-CoV-2
infection
continue
more
than
twelve
weeks
without
any
alternative
diagnosis.
One
most
frequent
persistent
reported
patients
verified
in
neuroimaging
studies
cognitive
dysfunction,
due
to
generalized
hypoconnectivity
diffuse
axonal
lesion
white
matter.
Therefore,
objectives
present
review
are
determine
how
long
functions
remain
affected
explore
which
beyond
three
months
follow-up
up
65
years
age
previous
neuropsychological
psychiatric
complications.
Methods:
A
systematic
was
performed
using
PRISMA
criteria
11
articles
were
included
through
comprehensive
search
five
different
databases:
PubMed,
Medline,
Scopus,
WOS
ProQuest.
The
risk
bias
assessed
Newcastle-Ottawa
scale.
Results:
Cognitive
problems
persist
over
time
improve
slowly,
although
seem
agree
areas
improved
significantly
one
year.
remained
impaired
longest
processing
speed
attention.
Conclusions:
These
alterations
cause
reduction
quality
life
work
capacity
manifest
need
intervention.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Фев. 26, 2025
Abstract
Long-term
changes
in
health-related
quality
of
life
(HrQoL)
after
SARS-CoV-2
infection
are
common,
but
their
causes
and
consequences
poorly
understood.
This
prospective,
population-based
study
examined
associations
between
HrQoL
49
demographic
clinical
variables.
was
assessed
using
the
European
Quality-of-Life-5-Dimensions-5-Level-Version
3,475
participants
(56%
female;
aged
18–88
years)
approximately
9
months
(baseline)
26
(follow-up)
initial
infection.
Results
were
compared
with
variables
recursive
feature
elimination
random
forest
regression
analyses.
A
statistically
significant
improvement
observed
during
observation
period.
At
baseline,
39%
variance
explained
by
fatigue,
muscle
pain,
number
remaining
symptoms
(RS),
perceived
stress,
age.
follow-up,
RS,
joint
age
54%
HrQoL.
Changes
associated
meaning
that
if
these
decreased
from
baseline
to
then
improved.
However,
it
not
possible
predict
whether
an
individual’s
would
improve
or
worsen
1
year
later
based
on
variable
scores.
The
aforementioned
specifically
impairment
population’s
usual
activities.
Journal of Rehabilitation Medicine,
Год журнала:
2025,
Номер
57, С. jrm42254 - jrm42254
Опубликована: Апрель 6, 2025
Objective:
To
present
a
radically
interdisciplinary
research
approach
to
ill-defined
symptoms,
with
focus
on
fatigue
as
major
symptom
of
post
COVID-19
condition,
where
multiple
and,
date,
rarely
combined
approaches
may
yield
fuller
understanding
these
symptoms.
Design:
Protocol
for
mixed-methods
study
comprising
an
cross-analysis.
Patients:
35
persons
condition
and
severe
were
included,
age-,
sex-,
educationally
matched
controls
who
recovered
from
without
condition.
Methods:
Participants
assessed
by
multidisciplinary
team
follows:
physician
assessment;
blood
urinalysis;
spirometry
physical
performance
tests;
neuropsychological
structural
functional
magnetic
resonance
imaging;
extended
immunological
tests
(cytokines);
qualitative
phenomenological
analysis
interviews.
Data
will
be
analysed
in
accordance
established
methods
each
fields
cross-analysis
methodology
developed
within
enactive
framework.
This
framework
encompasses
neuroscientific,
physiological,
experiential
aspects
the
person
living
being
their
sociocultural
world.
Conclusion:
The
biopsychosocial
model
needs
implemented
according
that
allow
different
paradigms,
typically
seen
incommensurable,
inform
other
non-reductionist
manner.
One
application
such
is
therefore
described.
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 13, 2024
There
is
a
growing
interest
in
the
effect
of
Long-COVID
(LC)
on
cognition,
and
neuroimaging
allows
us
to
gain
insight
into
structural
functional
changes
underlying
cognitive
impairment
LC.
We
used
multimodal
data
combination
with
neuropsychological
evaluations
study
complaints
cohort
LC
patients
mild
moderate
severity
symptoms.
Clinical neuroimaging.,
Год журнала:
2024,
Номер
1(1-2)
Опубликована: Март 1, 2024
Abstract
Background
and
purpose
Subjective
cognitive
complaints
post‐COVID‐19,
known
as
long‐COVID,
have
unclear
effects
on
neural
activity.
This
study
explores
the
basis
of
these
impairments
by
comparing
resting‐state
functional
networks
long‐COVID
individuals
to
a
control
group.
Methods
Forty‐two
with
persisting
24
weeks
post
COVID‐19
infection
43
age‐,
sex‐
education‐matched
healthy
controls
without
history
were
studied
using
MRI
(rs‐fMRI)
Uniform
Data
Set
(UDS‐3)
neurocognitive
test
battery
(NCT).
Neuropsychological
scores
adjusted
mean
grouped
into
seven
composites.
The
rs‐fMRI
data
partitioned
distinct
—
Salience/Ventral
Attention,
Dorsal
Default,
Frontoparietal,
Visual,
Somatomotor,
Limbic
their
efficiency,
largest
connected
component,
modularity
(Q)
studied.
Results
NCT
yielded
statistically
significant
differences
in
subjects
compared
at
attention,
language,
memory,
executive,
global
We
observed
(
p
<
.001)
local
efficiency
Attention
Global
networks,
lesser
extent
.005
.01)
Default
networks.
Conclusions
Our
findings
reveal
group‐level
attentional,
memory
outcomes,
alongside
less
efficient
organized
connections
among
