Melatonin and the Skin: Current Progress and Perspectives for Human Health
Journal of Investigative Dermatology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Melatonin as an adjunctive therapy in cardiovascular disease management
Science Progress,
Год журнала:
2024,
Номер
107(4)
Опубликована: Окт. 1, 2024
Melatonin,
N-acetyl-5-methoxytryptamine,
is
a
neuroendocrine
hormone
secreted
by
the
pineal
gland.
This
pleiotropic
indoleamine
possesses
amphiphilic
properties,
allowing
it
to
penetrate
most
biological
barriers
and
exert
its
effects
at
subcellular
level.
Importantly,
melatonin
also
plays
crucial
role
in
regulating
body's
response
circadian
rhythms,
adapting
internal
external
environmental
cues.
Melatonin
functions
as
powerful
antioxidant
free
radical
scavenger,
protecting
cells
from
oxidative
damage.
Its
diverse
physiological
roles
include
maintaining
functional
integrity
of
endothelial
cells,
thereby
preventing
atherosclerosis,
major
contributor
cardiovascular
disease.
Additionally,
exhibits
scavenging
potentially
improving
metabolic
disorders.
These
combined
suggest
unique
adjunctive
therapeutic
potential
for
treating
diseases.
review
aims
explore
mechanisms
which
interacts
with
system
investigates
use
an
agent
managing
Язык: Английский
IN SILICO STUDIES AND CYTOTOXICITY ASSAY OF BENZYLIDENE BENZO HYDRAZIDE DERIVATIVES ON CANCER STEM CELL
International Journal of Applied Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 134 - 141
Опубликована: Март 7, 2025
Objective:
This
study
aimed
to
evaluate
the
biological
activity
of
benzylidene
benzohydrazide
derivatives
against
Cancer
Stem
Cells
(CSCs)
through
in
vitro
cytotoxicity
tests
and
silico
analyses
using
molecular
docking.
Methods:
Four
hydrazone
compounds,
namely
benzo
hydrazide
(L1),
2-methyl
(L2),
2-nitro
(L3),
2-bromobenzylidene
(L4)
were
used
for
studies.
The
interaction
between
compounds
EGFR
protein
receptor
(PDB
ID:
1m17)
was
investigated
AutoDock
tools
1.5.7.
PASS
server
predicted
activities
substances.
ADMET
assessed
ADMETLab
2.0.
Meanwhile,
cytotoxic
test
on
CSCs
evaluated
MTT
Assay
method.
Results:
results
docking
analysis
L1-L4
provide
binding
energy
values
ranging
from
-6.69
to-7.74
kcal/mol.
value
is
lower
than
reference
Doxorubicin
(-4.30
Kcal/mol).
with
IC50
L1
0.220±0.360
μg/ml,
L2
0.034±0.023
L3
0.355±0.276
L4
1.193±1.122
μg/ml
0.220±0.180
μg/ml.
These
indicate
that
have
potential
be
inhibitor.
Conclusion:
(L2)
had
as
a
inhibitor
vigorous
cell
lines
Язык: Английский
In Silico Discovery of Multi-Target Natural Ligands and Efficient siRNA Design for Overcoming Drug Resistance in Breast Cancer via Local Therapy
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
In
this
study,
we
designed
an
efficient
siRNA
for
PKMYT1
gene
knockdown,
and
evaluated
the
binding
affinities
of
different
natural
ligands
to
crucial
proteins
involved
in
breast
cancer.
Designed
showed
strong
affinity
minimal
off-target
effects.
Molecular
docking
studies
identified
new
as
antagonists
with
high
aromatase,
estrogen
receptor
alpha,
HER2,
PARP10,
well
agonists
MT2
STING.
The
ligand
SCHEMBL7562664
was
introduced
a
golden
due
its
among
multiple
targets
lack
cytotoxic
mutagenic
Natural
small
molecules
research,
their
multi-target
characteristics,
provided
solution
overcome
problem
drug
resistance
cancer
cells.
Furthermore,
proposed
three
dimensional
scaffold
design
local
therapy
offers
promising
approach
increase
delivery
efficacy
these
molecules,
reduce
systemic
side
effects,
improve
treatment
outcomes.
significant
favorable
pharmacokinetic
properties
were
identified,
which
paves
way
further
research
targeted
Язык: Английский