Chitosan and hyaluronic acid in breast cancer treatment: Anticancer efficacy and nanoparticle and hydrogel development

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 301, С. 140144 - 140144

Опубликована: Янв. 21, 2025

Язык: Английский

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Exploring structural and spectroscopic aspects, solvent effect (polar and non-polar) on electronic properties, topological insights, ADME and molecular docking study of thiocolchicoside: A promising candidate for antiviral and antitumor pharmacotherapy

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Год журнала: 2025, Номер unknown, С. 125807 - 125807

Опубликована: Янв. 1, 2025

Язык: Английский

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Biomedical Applications of Lauric Acid: A Narrative Review

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Июнь 20, 2024

Lauric acid, a major component of coconut oil, has been studied for its various health benefits over the years. acid is medium-chained fatty with several potential biomedical applications based on antimicrobial action, capacity drug delivery, tissue engineering scaffolds, and cleansing capabilities. Various studies are carried out in vitro vivo using experimental animals, such as rats, shedding light efficacy lauric acid. The related to were brought under one umbrella emphasized need further research explore human health. This review aims scientifically assess reported data present narrative medicine.

Язык: Английский

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Design, Synthesis and Bioactive Evaluation of Topo I/c-MYC Dual Inhibitors to Inhibit Oral Cancer via Regulating the PI3K/AKT/NF-κB Signaling Pathway

Molecules, Год журнала: 2025, Номер 30(4), С. 894 - 894

Опубликована: Фев. 14, 2025

The significantly rising incidence of oral cancer worldwide urgently requires the identification novel, effective molecular targets to inhibit progression malignancy. DNA topoisomerase I (Topo I) is a well-established target for treatment, and many studies have shown that different cell genes could be targeted more selectively with one type Topo inhibitor. In this report, new scaffold pyridothieno[3,2-c]isoquinoline 11,11-dioxide was designed via combination key fragment or bioisoster inhibitor azaindenoisoquinolines G-quadruplex binder quindoline. Thirty-two derivatives were synthesized, among which compounds 7be, potent inhibition, exhibited antiproliferative activity against Cal27, lines highly expressing protein. Further indicated 7be also activation PI3K/AKT/NF-κB pathway downregulate level c-MYC, repress colony formation migration Cal27 cells trigger apoptosis autophagy. Molecular docking interact complex mode similar indenoisoquinolines. results xenograft model confirmed promising anticancer efficacy in vivo, tumor growth inhibition (TGI) 64.7% at 20 mg/kg.

Язык: Английский

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Cytocompatibility and bone regeneration potential of chitosan-thiocolchicoside-lauric acid nanogel with insights into zebrafish toxicology

Exploration of Medicine, Год журнала: 2025, Номер unknown

Опубликована: Апрель 21, 2025

Aim: The present study explored the bone regeneration potential of chitosan-thiocolchicoside-lauric (CTL) nanogel using MG-63 cell lines. cytocompatibility CTL was also studied osteoblast-like cells (MG-63 lines) and zebrafish embryos. Methods: effect on metabolic wound-healing activity investigated in study. alkaline phosphatase (ALP) sialoprotein (BSP) nanogel-treated were assessed ELISA. RUNX2, ALP, BSP, COL1A1 gene expression after treatment with nanogel. Hatching rates viability embryos treated different concentrations studied. Any developmental toxicity investigated. Results: There no significant reduction proliferation when 5–20 μL/mL MTT assay (p < 0.05). No prominent morphological changes or nuclear abnormalities found various compared to control group. Invitro scratch wound healing showed excellent migration and, hence, ability ELISA ALP BSP cells. significantly increased group hatching as decreased, highest rate observed at a 5 µL concentration. Developmental toxicity, such spinal cord bent, tail yolk sac oedema, not Conclusions: can be used treating defects helping healing. suggests that had concentration-dependent embryos’ only very high concentrations.

Язык: Английский

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Longitudinal Assessment of the Quality of Life in Oral Squamous Cell Carcinoma Patients

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Май 19, 2024

Background Studies evaluating the quality of life (QoL) among oral cancer patients in Indian population are scarce. Regular follow-ups and QoL assessment squamous cell carcinoma (OSCC) can aid comprehensive support strategies to improve their outcomes. Aim objectives This study aimed assess correlate with demographic treatment parameters. Materials methods The included who had previously reported Department Oral Maxillofacial Surgery. was done using EORTC QLQ-C30 QLQ-HN43 questionnaires before after treatment. clinico-demographic details, data, follow-up recorded mean were procured from patient records Dental Information Archival Software. Assessment at intervals one month, three months, six 12 24 36 months postoperatively Statistical analysis performed IBM SPSS Statistics for Windows, Version 23 (released 2015; Corp., Armonk, New York, United States). A repeated measures variance (ANOVA) utilized comparing average scores frequency across various intervals. Chi-square tests assessed differences genders, different sites, between primary closure graft placement. significance set a p-value less than 0.05. Results total 90 OSCC department. preoperative (100%) patients. Out these patients, surgery has been on 41 (45%). Twenty-five out (60%) responded regular follow-up, After immediate postoperative phase, only (48%) months. Only (24%) 12-month five (20%) two-year (4%) three-year follow-up. There constant decrease number (p=0.00). Prior treatment, index 4.64. Females slightly higher 4.76 compared males, score 4.67 (p=0.157). Immediately OSCC, decline noted, 4.25 (p=0.32). Patients underwent excision post-op 4.9, while placement 4.6 Conclusion highlights enduring impact patient's emphasizes need ongoing research explore specific interventions that contribute sustained improvement QoL. It personalized, holistic care approaches such

Язык: Английский

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Exploring the anticancer and antioxidant potential of gold nanoparticles synthesized from Pterocarpus marsupium bark extract against oral squamous cell carcinoma

Artificial Cells Nanomedicine and Biotechnology, Год журнала: 2024, Номер 52(1), С. 512 - 528

Опубликована: Окт. 25, 2024

Oral squamous cell carcinoma (OSCC) is a disease of significant concern with higher mortality rates. Conventional treatment approaches have several drawbacks, leading to the opening new research avenues in field nanoparticle-based cancer therapeutics. The study aimed at synthesis gold nanoparticles (Pm-AuNPs) from aqueous bark extract Pterocarpus marsupium, followed by its characterization and vitro anticancer evaluation against OSCC. synthesized Pm-AuNPs were characterized using UV–visible spectroscopy, particle size analyser, zeta potential, FTIR SEM techniques. potential was evaluated OSCC lines (SCC29b, SSC154 OECM-1) through assays. IC50 value found be 25 ± 1.2, 45 1.5 75 2.1 µg/mL for three lines, elucidating cytotoxic effects mechanism action. Intracellular ROS SOX detection, mitochondrial transmembrane analysis apoptosis detection used confirm activity Acute toxicity studies on Wistar rats confirmed non-toxic nature dose concentration up 2000 mg/kg body weight. findings underscore as promising candidates future therapeutics, providing insights into their action therapeutic efficacy

Язык: Английский

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Recent advances in nanomedicine for innovative oral cancer therapeutics—a review

Journal of Nanoparticle Research, Год журнала: 2024, Номер 26(12)

Опубликована: Ноя. 26, 2024

Язык: Английский

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