Electrospun chitosan/polycaprolactone wound dressing containing henna extract and vitamin C: A natural composite for wound care
Polymer Engineering and Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Abstract
The
present
study
shows
an
incredibly
promising
wound
dressing
material
based
on
electrospun
chitosan
(CS)/polycaprolactone
(PCL)
fibers
that
are
enhanced
with
henna
extract
(HE)
and
vitamin
C
(VitC).
incorporation
of
HE,
a
traditional
medicinal
herb
known
for
its
healing
capabilities,
Vit
C,
powerful
antioxidant,
into
CS
takes
use
CS's
natural
biocompatibility
antibacterial
characteristics.
This
combination
requires
to
generate
synergistic
effect
enhances
provides
protection
against
infection.
scaffolds
were
created
investigated
determine
their
surface
morphology,
chemical
composition,
ability
water
swelling,
strength,
kill
bacteria.
results
indicate
the
inclusion
HE
substantially
improved
absorbing
water,
which
is
essential
encouraging
attachment
cells
maintaining
moisture,
both
critical
wounds.
Furthermore,
containing
shown
significant
efficacy
Escherichia
coli
Staphylococcus
aureus
,
demonstrating
capacity
prevent
According
in
vitro
evaluation,
sample
1
wt%
VitC
exhibited
exceptional
cell
adhesion
L929
fibroblast
line.
introduces
innovative
has
customized
mixture
substances.
approach
addresses
gaps
previous
CS/PCL
studies,
introducing
composite
advanced
care
applications.
Highlights
Electrospun
CS/PCL‐HE/VitC
potential.
improve
antimicrobial
properties.
scaffold
demonstrates
moisture
retention
application.
activity
E.
S.
aureus.
In
studies
show
excellent
cells.
Язык: Английский
Antibacterial and Biodegradable PLA-based Nanofibers Loaded with Natural Phenolic Monoterpenes for Sustainable Biomedical or Food Application
New Biotechnology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Antibacterial
biodegradable
PLA-based
nanofibers
loaded
with
phenolic
monoterpenes
-
thymol,
eugenol,
carvacrol,
and
cinnamaldehyde,
were
prepared
by
electrospinning.
The
effect
of
bioactive
molecule
on
the
surface,
thermal,
morphological,
biological
properties
has
been
investigated
about
potential
pharmaceutical
food
processing
applications.
Fiber
diameters
ranged
from
320nm
for
PLA
fibrous
mat
up
to
480nm
membrane
6%
thymol.
All
active
exhibited
hydrophobic
surfaces
a
slightly
decreasing
contact
angle
after
incorporation
phenols.
Antimicrobial
testing
proved
strong
efficiency
against
Escherichia
coli
Staphylococcus
aureus,
depending
specific
type
content
compound.
A
significant
biofilm
formation
reduction
was
revealed
tested
microorganisms.
Modification
fibers
molecules
did
not
significantly
affect
biodegradation
kinetics
in
comparison
samples
their
absence.
This
study
demonstrates
high
newly
developed
PLA-based/phenol
nanofibrous
membranes
use
as
antibacterial
antifouling
systems
applicable
wound
dressings
packaging.
Язык: Английский
Blood Plasma, Fibrinogen or Fibrin Biomaterial for the Manufacturing of Skin Tissue-Engineered Products and Other Dermatological Treatments: A Systematic Review
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(3), С. 79 - 79
Опубликована: Фев. 22, 2025
The
use
of
blood
plasma,
fibrinogen
or
fibrin,
a
natural
biomaterial,
has
been
widely
studied
for
the
development
different
skin
tissue-engineered
products
and
other
dermatological
treatments.
This
systematic
review
reports
preclinical
clinical
studies
which
it
alone
combined
with
biomaterials
and/or
cells
treatment
several
conditions.
Following
PRISMA
2020
Guidelines,
147
have
revealed
that
this
biomaterial
as
wound
dressing
monolayer
(one
cell
type)
substitute
are
preferred
strategies,
mainly
excisional
surgical
wounds.
Moreover,
plasma
is
used
although
its
combination
such
agarose,
polyethylene
glycol
collagen
also
reported
to
increase
healing
potential.
However,
most
17
reviewed
evaluated
severely
burned
patients
bilayer
(two
types)
substitute.
Although
number
evaluating
increased
during
last
fifteen
years,
not
correlated
wide
variety
studies.
Its
safety
potential
proved;
however,
lack
standard
model
presence
approaches
meant
translation
environment
still
limited.
A
higher
should
be
carried
out
in
coming
years
set
strategy
each
disease.
Язык: Английский
Fabrication of curcumin‑incorporated poly glycerol sebacate/poly lactide acid (PGS/PLA) hydrogel to enhance full‑thickness wound healing in diabetic rats
Tissue and Cell,
Год журнала:
2025,
Номер
unknown, С. 102856 - 102856
Опубликована: Март 1, 2025
Язык: Английский
Chitosan/poly (β‐amino ester) hydrogel by controlled release of Centella Asiatica promoted wound healing through improved collagen expression and antibacterial and anti‐inflammatory properties
Polymer Engineering and Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 25, 2025
Abstract
Burn
wound
healing
presents
several
challenges,
including
impaired
collagen
synthesis,
delayed
closure,
and
disrupted
inflammatory
responses.
This
study
investigates
the
potential
of
a
novel
UV‐crosslinked
hydrogel
made
chitosan
(CS)/poly(β‐amino
ester)
(PβAE)
Centella
Asiatica
extract
(CA)
for
second‐degree
burn
treatment.
Among
various
formulations,
monomer
ratio
1.5:1
5
wt%
2,2‐dimethoxy‐2‐phenyl‐acetophenone
DMPA
crosslinker
concentration
were
found
optimal.
The
achieved
~74%
controlled
release
CA
over
72
h
showed
significant
enhancement
in
fibroblast
viability
(123.66
±
9%
at
days).
Scratch
assay
demonstrated
~99.5%
closure
within
24
h.
Collagen
type
I
expression
was
increased
by
~1.7‐fold
compared
with
control.
Additionally,
exhibited
remarkable
anti‐inflammatory
properties,
effectively
modulating
response.
It
significantly
reduced
pro‐inflammatory
markers
such
as
IL‐6
TNF‐α
while
simultaneously
enhancing
levels
cytokines,
IL‐10
TGF‐β.
dual
action
not
only
mitigates
inflammation
but
also
fosters
regenerative
environment,
further
supporting
process
promoting
tissue
recovery.
antibacterial
properties
inhibition
zones
~19.1
mm
E.
coli
~12.4
S.
aureus
.
These
results
suggest
that
this
biocompatible,
biodegradable
is
promising
therapeutic
candidate
wounds.
Highlights
Developed
chitosan/PβAE
burns.
Optimized
releases
Boosts
viability,
migration,
1.7x.
Reduces
IL‐6,
TNF‐α,
IL‐10,
Strong
against
aureus.
Язык: Английский
Advancements in nanotechnology for biomedical and wearable applications
Next Materials,
Год журнала:
2025,
Номер
8, С. 100658 - 100658
Опубликована: Апрель 18, 2025
Язык: Английский
Oxygen-generating and antibacterial xanthan gum/PLA aerogels loaded with dexamethasone for potential wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143314 - 143314
Опубликована: Апрель 1, 2025
Язык: Английский
Preparation and characterization of an antibacterial CMC/PCL hydrogel films containing CIP/Cur: In vitro and in vivo evaluation of wound healing activity
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
282, С. 136570 - 136570
Опубликована: Окт. 15, 2024
Язык: Английский
Anti-apoptotic effect of umbilical cord cryoextract and its lyophilized form on L929 cells
Regulatory Mechanisms in Biosystems,
Год журнала:
2024,
Номер
15(4), С. 980 - 984
Опубликована: Ноя. 20, 2024
The
umbilical
cord
cryoextract
(UCC)
and
its
lyophilized
form
(LUCC)
contain
numerous
biologically
active
components,
including
growth
factors,
cytokines,
other
regulatory
molecules,
which
may
exert
an
anti-apoptotic
effect
on
cells.
This
study
aimed
to
determine
whether
these
samples
can
reduce
apoptosis
levels
in
healthy
cells,
is
particularly
relevant
scenarios
where
be
induced
by
chemotherapeutic
agents
such
as
doxorubicin.
To
evaluate
the
potential
protective
effects
of
cryoextracts,
L929
cell
line
treated
with
doxorubicin,
a
known
inducer,
was
selected
model
for
assessing
properties
UCC
LUCC.
In
experiment,
cells
were
cultured
standard
Dulbecco's
Modified
Eagle
Medium
(DMEM)
addition
Experimental
results
demonstrated
that
fetal
bovine
serum
(FBS),
UCC,
LUCC
significantly
reduced
compared
group
doxorubicin
alone.
LUCC,
comparable
those
FBS
group,
indicating
supportive
both
forms
cryoextracts.
These
findings
suggest
serve
effective
reducing
apoptosis,
maintaining
stability
their
components
even
post-lyophilization.
support
use
cryoextracts
chemotherapy
involving
mitigate
toxic
side
effects.
Further
research
needed
elucidate
mechanisms
action
extracts
assess
efficacy
vivo,
open
new
opportunities
application
oncology
therapy
medical
fields.
Язык: Английский