Hyaluronic acid-silybin conjugate for the preparation of multifunctional, biomimetic, vancomycin-loaded self-assembled polymersomes against bacterial sepsis
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
299, С. 140152 - 140152
Опубликована: Янв. 22, 2025
Язык: Английский
Folic acid-targeted β-lactoglobulin nanocarriers for enhanced delivery of 5-fluorouracil and sodium butyrate in colorectal cancer treatment
International Journal of Pharmaceutics,
Год журнала:
2025,
Номер
unknown, С. 125262 - 125262
Опубликована: Янв. 1, 2025
Язык: Английский
Schiff bases of cellulose: Synthesis, characterization, and anticancer potency against hepatocellular carcinoma
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140506 - 140506
Опубликована: Янв. 1, 2025
Язык: Английский
RGD peptide-functionalized micelles loaded with crocetin ameliorate doxorubicin-induced cardiotoxicity
International Journal of Pharmaceutics X,
Год журнала:
2025,
Номер
9, С. 100326 - 100326
Опубликована: Фев. 26, 2025
Язык: Английский
Efficacy of graphene quantum dot-hyaluronic acid nanocomposites containing quinoline for target therapy against cancer cells
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 12, 2025
Abstract
The
study
aims
to
assess
the
impact
of
graphene
quantum
dot-hyaluronic
acid-quinoline
nanocomposites
(GQD-HA-Qu
NCs)
on
MCF-7,
HT-29,
A2780,
PANC-1,
and
HeLa
cell
lines.
GQD-HA-Qu
NCs
were
characterized
using
dynamic
light
scattering
(DLS),
field
emission
scanning
electron
microscopy
(FESEM),
Fourier-transform
infrared
(FTIR)
spectroscopy.
MTT
assays
flow
cytometry
evaluated
cytotoxic
apoptotic
effects
synthesized
NCs.
Additionally,
real-time
PCR
was
utilized
gene
expression.
DLS
assay
revealed
a
particle
size
224.96
nm
with
polydispersity
index
(PDI)
0.3.
FESEM
analysis
also
confirmed
uniform
spherical
morphology
assessment
demonstrated
significant
cytotoxicity
in
all
lines,
MCF-7
A2780
exhibiting
pronounced
sensitivity
(
P
<
0.001).
analyses
dose-dependent
increase
late
apoptosis
at
higher
concentrations
Notably,
p53
expression
significantly
upregulated
compared
untreated
cells
0.01),
while
caspases
8
9
showed
no
substantial
change.
This
finding
indicates
that
pathway
is
predominant
mediating
NCs-induced
apoptosis.
present
suggests
are
promising
treatment
selective
against
cancer
robust
antioxidant
activity.
These
findings
warrant
further
investigation
for
potential
clinical
applications.
Язык: Английский
Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway
Nan Yan,
Gaofu Li,
Linglin Zhao
и другие.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 21, 2025
Introduction:
Gastric
cancer
(GC)
is
characterized
by
high
incidence
and
poor
survival
rates.
Crocin,
a
natural
carotenoid
from
saffron,
exhibits
antioxidant,
anti-inflammatory,
anti-tumor
properties.
Ferroptosis,
an
iron-dependent
cell
death
driven
lipid
peroxidation,
plays
critical
role
in
progression
potential
therapeutic
target.
This
study
investigates
whether
crocin
inhibits
GC
proliferation
inducing
ferroptosis
explores
its
underlying
mechanisms.
Methods:
employed
vivo
vitro
models
to
assess
crocin’s
effects
on
proliferation,
apoptosis,
migration,
invasion,
ferroptosis.
Pathway
enrichment
analysis
was
performed
differentially
expressed
genes
post-crocin
treatment.
Lentiviral
vectors
were
used
knockdown
overexpress
GGTLC2,
exploring
effects.
The
UCSC
JASPAR
databases
predicted
Nrf2
binding
sites
the
GGTLC2
promoter.
Molecular
docking
evaluated
affinity
for
GGTLC2.
Immunofluorescence
nuclear-cytoplasmic
fractionation
assays
analyzed
expression
localization.
ChIP-qPCR
determined
Nrf2’s
regulatory
modulatory
Results:
results
demonstrated
that
significantly
inhibited
invasion
of
cells
while
promoting
apoptosis.
Differentially
following
treatment
predominantly
enriched
pathways
associated
with
oxidative
stress
Crocin
downregulated
oncogene
thereby
suppressing
simultaneously
apoptosis
revealed
stable
between
suggesting
may
directly
target
modulate
expression.
Additionally,
facilitated
translocation
nucleus
cytoplasm.
confirmed
binds
promoter
region
regulate
expression,
attenuated
this
interaction.
Discussion:
In
conclusion,
our
findings
suggest
crocin,
as
promising
compound
therapy,
inhibit
through
Nrf2/GGTLC2
signaling
pathway,
tumor
initiation
progression.
provides
novel
insights
into
molecular
mechanisms
highlights
agent
GC.
Язык: Английский
Targeted cancer therapy potential of quercetin-conjugated with folic acid-modified nanocrystalline cellulose nanoparticles: a study on AGS and A2780 cell lines
BMC Biotechnology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 16, 2025
Язык: Английский
Unveiling ferroptosis: a new frontier in skin disease research
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 4, 2024
Ferroptosis,
a
form
of
regulated
cell
death
distinct
from
apoptosis,
necrosis,
and
autophagy,
is
increasingly
recognized
for
its
role
in
skin
disease
pathology.
Characterized
by
iron
accumulation
lipid
peroxidation,
ferroptosis
has
been
implicated
the
progression
various
conditions,
including
psoriasis,
photosensitive
dermatitis,
melanoma.
This
review
provides
an
in-depth
analysis
molecular
mechanisms
underlying
compares
cellular
effects
with
other
forms
context
health
disease.
We
systematically
examine
five
specific
diseases,
ichthyosis,
polymorphous
light
eruption
(PMLE),
vitiligo,
melanoma,
detailing
influence
on
pathogenesis
progression.
Moreover,
we
explore
current
clinical
landscape
ferroptosis-targeted
therapies,
discussing
their
potential
managing
treating
diseases.
Our
aim
to
shed
therapeutic
modulating
research
practice.
Язык: Английский