SLAS DISCOVERY, Год журнала: 2024, Номер unknown, С. 100203 - 100203
Опубликована: Дек. 1, 2024
Язык: Английский
BMC Pulmonary Medicine, Год журнала: 2025, Номер 25(1)
Опубликована: Янв. 31, 2025
Pulmonary fibrosis is characterized by the destruction of normal lung tissue and then replacement abnormal fibrous tissue, leading to an overall decrease in gas exchange function. The effective treatment for pulmonary remains unknown. upstream pathogenesis may involve cellular senescence tissue. Previously, a new gene therapy technology using Box A HMGB1 plasmid (Box A) was used reverse cure liver aged rats. Here, we show that promising medicine fibrosis. In bleomycin-induced model male Wistar rats, Student's t-test one-way ANOVA were compare groups samples. effectively lowered deposits (from 18.74 ± 0.62 3.45 1.19%) senescent cells 3.74 0.40% 0.89 0.18%) levels comparable those negative control group. Moreover, after eight weeks, also increased production surfactant protein C 3.60 1.68% 6.82 0.65%). Our results demonstrate therapeutic approach other senescence-promoted fibrotic lesions.
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117870 - 117870
Опубликована: Янв. 26, 2025
Язык: Английский
Процитировано
0
Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Journal of Clinical & Translational Ophthalmology, Год журнала: 2025, Номер 3(2), С. 6 - 6
Опубликована: Март 26, 2025
Over 2.2 billion people across the globe face significant barriers to accessing essential ophthalmic care, with elderly, rural, and refugee populations being disproportionately affected, deepening existing disparities in eye care. Three-dimensional printing is a novel technology that has potential transform field improve access by alleviating many patient-specific barriers. This article delves into evolution of 3D within ophthalmology, highlighting its current applications future potential. It explores various techniques numerous biomaterials discussing their effectiveness creating advanced solutions such as bioengineered corneas, ocular prosthetics, innovative treatments for dry syndrome, from punctal plugs lacrimal gland models. Additionally, revolutionized drug delivery systems conditions like glaucoma, retinal diseases, brachytherapy. Whether through printed contact lens-based or polycaprolactone implants biodegrade provide sustained release without adverse effects, these hold immense field. Despite promise, integration clinical practice presents challenges, which addresses alongside strategies overcoming them. By mapping out technological advancements this review offers roadmap enhancing global care accessibility improving patient outcomes on scale.
Язык: Английский
Процитировано
0
Burns, Год журнала: 2025, Номер unknown, С. 107456 - 107456
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Materials, Год журнала: 2024, Номер 17(22), С. 5425 - 5425
Опубликована: Ноя. 6, 2024
The lacrimal gland (LG) is vital for ocular health, producing tears that lubricate and protect the eye. Dysfunction of LG leads to aqueous-deficient dry eye disease (DED), significantly impacting quality life. Current treatments mainly address symptoms rather than underlying dysfunction, highlighting need regenerative therapies. Tissue engineering offers a promising solution, with biomaterials playing crucial roles in scaffolding supporting cell growth regeneration. This review focuses on recent advances used tissue gland. We discuss both natural synthetic mimic extracellular matrix provide structural support proliferation differentiation. Natural biomaterials, such as Matrigel, decellularized matrices, chitosan, silk fibroin hydrogels, human amniotic membrane are evaluated their biocompatibility ability cells. Synthetic like polyethersulfone, polyesters, biodegradable polymers (PLLA PLGA), assessed mechanical properties potential create scaffolds replicate complex architecture LG. also explore integration factors stem cells these enhance Challenges achieving proper vascularization, innervation, long-term functionality engineered tissues discussed. Advances 3D bioprinting scaffold fabrication techniques highlighted avenues overcome current limitations.
Язык: Английский
Процитировано
2
SLAS DISCOVERY, Год журнала: 2024, Номер unknown, С. 100203 - 100203
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0