Depression reduces cognitive function partly through effects on BMI and hypertension: a large observational study and Mendelian randomization analysis DOI Creative Commons

Hongyang Gong,

Zhao Wang, Yanyan Chen

и другие.

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 17, 2025

While abundant evidence suggests a correlation between depression and the risk of cognitive impairments, causal relationship, as well mechanisms mediating this association, remain uncertain. We conducted an observational study within National Health Nutrition Examination Survey (NHANES), simultaneously employing weighted multivariable-adjusted linear regression to explore association them. Subsequently, Mendelian randomization analysis was employed investigate relationship them effects. The NHANES data indicates that is independently associated with function. Regarding MR, genetically predicted causally related function in IVW method (OR 0.33, 95% CI 0.14-0.78, P = 0.012). Furthermore, leads obesity 1.91, 2.53 × 10 - 3) elevated blood pressure 2.34, 3.62 3). Waist circumference 0.85, 3.00 4), BMI 0.84, 1.06 6), hypertension 0.95, 4.00 all contribute Additionally, there no 1.00, 0.99-1.01, 0.559) reverse randomization. Mediation mediate 9.9% 3.6% under conditions, respectively. Our can lead hypertension, which reduce These findings underscore importance timely identification management patients impairments suggest treatments aimed at reducing weight lowering may help prevent impairment.

Язык: Английский

The Relationship Between Grip Strength and Cognitive Impairment: Evidence From NHANES 2011–2014 DOI Creative Commons

Wenyi Nie,

Jingqing Hu

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

ABSTRACT Background Prior research has consistently shown an association between muscle strength and various metabolic diseases. However, the relationship cognitive impairment remains elusive. Methods Using data from 2011–2014 National Health Nutrition Examination Survey (NHANES), we investigated impairment. We used multivariate logistic regression, restricted cubic spline regression (RCS), threshold effects to investigate impact of on function. In addition, analyzed correlation in subgroups age, gender, race, education, smoking status, drinking hypertension, diabetes, heart disease. Results 2124 participants were ultimately included for further analysis. Multivariate trend testing, RCS analysis showed a non‐linear negative Threshold effect suggests that when reaches certain value, this undergoes significant changes. three function scoring tests, interaction was only observed racial subgroup. Conclusion This study function, which may have effect. Further longitudinal studies are needed elucidate its potential mechanisms.

Язык: Английский

Процитировано

0
Depression reduces cognitive function partly through effects on BMI and hypertension: a large observational study and Mendelian randomization analysis DOI Creative Commons

Hongyang Gong,

Zhao Wang, Yanyan Chen

и другие.

BMC Psychiatry, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 17, 2025

While abundant evidence suggests a correlation between depression and the risk of cognitive impairments, causal relationship, as well mechanisms mediating this association, remain uncertain. We conducted an observational study within National Health Nutrition Examination Survey (NHANES), simultaneously employing weighted multivariable-adjusted linear regression to explore association them. Subsequently, Mendelian randomization analysis was employed investigate relationship them effects. The NHANES data indicates that is independently associated with function. Regarding MR, genetically predicted causally related function in IVW method (OR 0.33, 95% CI 0.14-0.78, P = 0.012). Furthermore, leads obesity 1.91, 2.53 × 10 - 3) elevated blood pressure 2.34, 3.62 3). Waist circumference 0.85, 3.00 4), BMI 0.84, 1.06 6), hypertension 0.95, 4.00 all contribute Additionally, there no 1.00, 0.99-1.01, 0.559) reverse randomization. Mediation mediate 9.9% 3.6% under conditions, respectively. Our can lead hypertension, which reduce These findings underscore importance timely identification management patients impairments suggest treatments aimed at reducing weight lowering may help prevent impairment.

Язык: Английский

Процитировано

0