Integrating computational insights in gold nanoparticle-mediated drug delivery: enhancing efficacy and precision

Frontiers in Medical Technology, Год журнала: 2025, Номер 7

Опубликована: Фев. 24, 2025

Gold nanoparticles (AuNPs) have emerged as a versatile platform in biomedical applications, particularly drug delivery, cancer therapy, and diagnostics, due to their unique physicochemical properties. This review focuses on the integration of computational methods artificial intelligence (AI) with nanotechnology optimize AuNP-based therapies. Computational modeling is essential for understanding interactions between AuNPs biological molecules, guiding nanoparticle design improved targeting, stability, therapeutic efficacy. Recent advancements, including AI-driven models precision therapy combination antimicrobial peptides (AMPs) combat drug-resistant pathogens, are highlighted. The also discusses challenges such toxicity, targeting efficiency, need scalable synthesis, alongside limitations capturing complex environments. Emphasizing importance ongoing research interdisciplinary collaboration, this underscores potential integrating insights AuNP technology enhance precision, safety, effectiveness diagnostic approaches.

Язык: Английский

How Advanced Is Nanomedicine for Atherosclerosis?

International Journal of Nanomedicine, Год журнала: 2025, Номер Volume 20, С. 3445 - 3470

Опубликована: Март 1, 2025

Advances in nanotechnology have opened new avenues for precision therapy, personalized medicine, and multifunctional theranostics atherosclerosis (AS). This review provides a comprehensive overview of the role nanoparticles (NPs) medicine AS, discussing their applications, challenges, future prospects. The first analyzes current treatment landscape AS outlines potential biological targets therapy. Various nanocarriers, including organic, inorganic, hybrid systems, are evaluated therapeutic potential, with focus on targeted drug delivery, anti-inflammatory vascular repair, plaque stabilization, lipid clearance. Additionally, explores NP preparation methods, emphasizing strategies to enhance loading, stability, controlled release. Finally, translational challenges NP-based therapies, biocompatibility, large-scale production, regulatory hurdles, clinical implementation, critically analyzed. Future directions highlight importance interdisciplinary collaboration technological innovation advancing nanoparticle-based AS.

Язык: Английский