Cross-talks of GSH, mitochondria, RNA m6A modification, NRF2, and p53 between ferroptosis and cuproptosis in HCC: A review
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
302, С. 140523 - 140523
Опубликована: Фев. 1, 2025
Язык: Английский
Big data analysis and machine learning of the role of cuproptosis-related long non-coding RNAs (CuLncs) in the prognosis and immune landscape of ovarian cancer
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 25, 2025
Ovarian
cancer
(OC)
is
a
severe
malignant
tumor
with
significant
threat
to
women's
health,
characterized
by
high
mortality
rate
and
poor
prognosis
despite
conventional
treatments
such
as
cytoreductive
surgery
platinum-based
chemotherapy.
Cuproptosis,
novel
form
of
cell
death
triggered
copper
ion
accumulation,
has
shown
potential
in
therapy,
particularly
through
the
involvement
CuLncs.
This
study
aims
identify
risk
signatures
associated
CuLncs
OC,
construct
prognostic
model,
explore
therapeutic
drugs
impact
on
OC
behavior.
We
analyzed
ovarian
data
(TCGA-OV)
from
TCGA
database,
including
transcriptomic
clinical
376
patients.
Using
Pearson
correlation
LASSO
regression,
we
identified
8
signature
model.
Patients
were
categorized
into
high-
low-risk
groups
based
their
scores.
performed
survival
analysis,
model
validation,
drug
sensitivity
vitro
experiments
assess
model's
performance
functional
key
proliferation,
invasion,
migration.
The
demonstrated
predictive
power,
an
area
under
curve
(AUC)
0.702
for
1-year,
0.640
3-year,
0.618
5-year
survival,
outperforming
pathological
features
stage
grade.
High-risk
patients
exhibited
higher
Tumor
Immune
Dysfunction
Exclusion
(TIDE)
scores,
indicating
stronger
immune
evasion
ability.
Drugs
JQ12,
PD-0325901,
sorafenib
showed
reduced
IC50
values
high-risk
group,
suggesting
benefits.
In
revealed
that
knockdown
LINC01956,
CuLnc
signature,
significantly
inhibited
migration
cells
(P<0.05).
Our
explored
targets
OC.
findings
highlight
importance
response,
providing
new
insights
future
research
applications.
Язык: Английский
Glutathione Metabolism in Ferroptosis and Cancer Therapy
Cancer Letters,
Год журнала:
2025,
Номер
unknown, С. 217697 - 217697
Опубликована: Апрель 1, 2025
Язык: Английский
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis
Pharmacological Research,
Год журнала:
2025,
Номер
unknown, С. 107739 - 107739
Опубликована: Апрель 1, 2025
Pathological
myocardial
remodelling
is
the
initiation
of
pressure
overload-induced
heart
failure,
and
its
involvement
in
associated
molecular
mechanisms
remains
to
be
fully
elucidated.
The
aim
this
study
was
investigate
whether
Sirtuin3
(SIRT3)
can
affect
pathological
remodeling
by
regulating
cellular
cuproptosis
potential
mechanisms.
In
study,
we
found
that
overload
induced
pathologic
which
cardiomyocytes
showed
a
distinct
signature
accompanied
downregulation
SIRT3
expression.
vitro
experiments
demonstrated
copper
ions
reduced
expression
40%
(p<0.01)
via
lysosomal
degradation.
vivo
validation
35%
tissue.
And
knockdown
increased
cardiomyocyte
apoptosis.
contrast,
cardiomyocytes-specific
overexpression
adeno-associated
virus
vectors
attenuated
unaffected
circulating
levels
hepatic
renal
impairment.
Mechanistically,
reduction
become
ion-sensitive
state
cells
affecting
binding
ion
transporter
proteins
microtubule-associated
protein
1a/1b-Light
chain
3
(LC3)
cardiomyocytes.
Disturbance
homeostasis
leads
accumulation
development
cuproptosis.
These
findings
elucidate
novel
mechanism
affects
death
suggest
great
SIRT3-regulated
prevention
or
treatment
remodeling.
Язык: Английский
Excessive glutathione intake contributes to chemotherapy resistance in breast cancer: a propensity score matching analysis
World Journal of Surgical Oncology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 21, 2024
We
aim
to
explore
the
impact
of
excessive
glutathione
(GSH)
intake
on
chemotherapy
sensitivity
in
breast
cancer.
Clinicopathological
data
were
collected
from
460
cancer
patients
who
underwent
adjuvant
January
2016
December
2019
Zhengzhou
University
People's
Hospital.
The
clinicopathological
characteristics
following
GSH
treatment
and
compared
with
those
Non-GSH
group
after
1:2
propensity
score
matching
(PSM).
Intracellular
levels
expression
antioxidant
enzymes
(NRF2,
GPX4
SOD1)
evaluated
tumor
tissues
51
receiving
neoadjuvant
chemotherapy.
recurrence
rate
was
significantly
higher
(n
=
28,
31.8%)
than
that
39,
22.2%;
P
0.010).
Additionally,
HGSH
(high
intake,
≥
16
days)
exhibited
an
elevated
LGSH
(low
<
15
(46.8%)
vs.
n
52
(22.4%);
0.003).
Cox
regression
revealed
High
Ki67
30%,
Triple
negative
Lymphovascular
invasion
independent
risk
factors
progression
Among
chemotherapy,
intracellular
resistant
substantially
(P
0.001).
Excessive
may
contribute
resistance
cancer,
are
indicating
standardization
assist
reducing
resistance.
Язык: Английский