bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 11, 2025

Abstract Psychedelics can profoundly alter consciousness by reorganising brain connectivity; however, their effects are context-sensitive. To understand how this reorganisation depends on the context, we collected and comprehensively analysed largest psychedelic neuroimaging dataset to date. Sixty-two adults were scanned with functional MRI EEG during rest naturalistic stimuli (meditation, music, visual), before after ingesting 19 mg of psilocybin. Half participants ranked experience among five most meaningful lives. Under psilocybin, signals recorded eyes-closed conditions became similar those an eyes-open condition. This change manifested as increase in global connectivity associative regions a decrease sensory areas. We used machine learning directly link subjective psychedelics neural activity patterns characterised low-dimensional embeddings. show that psilocybin reorganised these trajectories into cohesive structured context quality experience, stronger self- boundary-related effects–which linked day-after mindset changes—leading more distinct representations. induces state ‘embeddedness’ arises when networks usually segregate internal external processing coherently integrate, aligning dynamics context. corresponded profound transformations perception self-boundaries, reducing distinction between self environment. Embeddedness serves bridging framework for understanding both therapeutic psychedelics. These findings provide new account large-scale neurocognitive demonstrate utility using methods assessing state- context-dependent association psychological outcomes.

Язык: Английский