Chronic meningitis: diagnostic and therapeutic challenges DOI
Matthew D. Smyth, Monica M. Diaz, Deanna Saylor

и другие.

Current Opinion in Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Purpose of review We recent advances in diagnosis and treatment chronic meningitis, focusing on tuberculous meningitis (TBM), cryptococcal (CM), syphilitic neuroborreliosis, recurrent meningitis. Noninfectious causes unique challenges faced resource-limited settings are also considered. Recent findings Novel biomarkers being identified that may be useful for the TBM [i.e. monokine induced by interferon-γ (MIG), plasminogen binding proteins] (i.e. CXCL13, neurofilament light protein, etc.) but require more validation. Much progress has been made regarding CM, with a new semiquantitative lateral flow assay showing high diagnostic prognostic utility clinical trials demonstrating regimens oral lipid nanocrystal formulation single dose liposomal amphotericin B maintain efficacy improved side effect profiles. An ongoing trial ceftriaxone early stage studies linezolid lead to changes recommended these conditions near future. Summary Diagnosis management remains significant challenge, further research is needed improve our therapeutic armamentariums. However, emergence potential disease course cause optimism.

Язык: Английский

A children patient with intracranial infection after brain surgery associated with elevated Torque Teno Virus DOI Creative Commons

Zicong Wang,

Zewei Liu, Kexin Yuan

и другие.

IDCases, Год журнала: 2025, Номер unknown, С. e02196 - e02196

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Chronic meningitis: diagnostic and therapeutic challenges DOI
Matthew D. Smyth, Monica M. Diaz, Deanna Saylor

и другие.

Current Opinion in Infectious Diseases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 4, 2025

Purpose of review We recent advances in diagnosis and treatment chronic meningitis, focusing on tuberculous meningitis (TBM), cryptococcal (CM), syphilitic neuroborreliosis, recurrent meningitis. Noninfectious causes unique challenges faced resource-limited settings are also considered. Recent findings Novel biomarkers being identified that may be useful for the TBM [i.e. monokine induced by interferon-γ (MIG), plasminogen binding proteins] (i.e. CXCL13, neurofilament light protein, etc.) but require more validation. Much progress has been made regarding CM, with a new semiquantitative lateral flow assay showing high diagnostic prognostic utility clinical trials demonstrating regimens oral lipid nanocrystal formulation single dose liposomal amphotericin B maintain efficacy improved side effect profiles. An ongoing trial ceftriaxone early stage studies linezolid lead to changes recommended these conditions near future. Summary Diagnosis management remains significant challenge, further research is needed improve our therapeutic armamentariums. However, emergence potential disease course cause optimism.

Язык: Английский

Процитировано

0