Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia DOI Creative Commons
Tomoaki Takata,

Sosuke Taniguchi,

Yukari Mae

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 15, 2025

Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial. Previous investigations have primarily included xanthine oxidase inhibitors; therefore, research dotinurad, a recently developed selective urate reabsorption inhibitor, necessary. This retrospective study 58 patients CKD; these, 29 newly initiated dotinurad and febuxostat. The effects febuxostat serum UA, urinary UA-to-creatinine ratio (UUCR), estimated glomerular filtration rate (eGFR) during 3 months were analyzed to compare their impacts renal function. Dotinurad decreased UA (8.40 ± 1.11 6.50 0.80 mg/dL [p < 0.001] 8.91 1.21 6.05 1.28 = 0.001], respectively). UUCR increased after (0.35 0.15 0.40 0.21 g/gCr 0.024]); however, it (0.33 0.12 0.06 0.002]). eGFR improved (33.9 15.2 36.2 15.9 mL/min/1.73 m2 0.001]). No change was observed treatment (33.4 19.6 34.1 21.6 m2). Renal function only thus highlighting its renoprotective beyond reduction UA.

Язык: Английский

Comparative assessment of the effects of dotinurad and febuxostat on the renal function in chronic kidney disease patients with hyperuricemia DOI Creative Commons
Tomoaki Takata,

Sosuke Taniguchi,

Yukari Mae

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 15, 2025

Although hyperuricemia is associated with chronic kidney disease (CKD), the impact of uric acid (UA)-lowering drugs on CKD has been controversial. Previous investigations have primarily included xanthine oxidase inhibitors; therefore, research dotinurad, a recently developed selective urate reabsorption inhibitor, necessary. This retrospective study 58 patients CKD; these, 29 newly initiated dotinurad and febuxostat. The effects febuxostat serum UA, urinary UA-to-creatinine ratio (UUCR), estimated glomerular filtration rate (eGFR) during 3 months were analyzed to compare their impacts renal function. Dotinurad decreased UA (8.40 ± 1.11 6.50 0.80 mg/dL [p < 0.001] 8.91 1.21 6.05 1.28 = 0.001], respectively). UUCR increased after (0.35 0.15 0.40 0.21 g/gCr 0.024]); however, it (0.33 0.12 0.06 0.002]). eGFR improved (33.9 15.2 36.2 15.9 mL/min/1.73 m2 0.001]). No change was observed treatment (33.4 19.6 34.1 21.6 m2). Renal function only thus highlighting its renoprotective beyond reduction UA.

Язык: Английский

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