Development of a ROS-responsive, glutathione-functionalized injectable hydrogel system for controlled drug release DOI
Kai Hu,

Linlin Liang,

Jian Song

и другие.

Journal of Biomaterials Applications, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Oxidative stress arises from an imbalance between excessive production of reactive oxygen species (ROS) and the body’s antioxidant defenses. In neurodegenerative diseases, this leads to ROS accumulation, causing neuronal dysfunction cell death. Traditional drug therapies often fail address dynamic nature neuroinflammation, limiting their therapeutic efficacy. To overcome challenge, we have developed innovative ROS-responsive injectable hydrogel. This hydrogel is designed detect oxidative sensitively release glutathione in a controlled manner, thereby modulating inflammation restoring damaged immune microenvironment facilitate tissue repair. The was synthesized by crosslinking polyvinyl alcohol (PVA) with sodium alginate modified 3-aminophenylboronic acid (Alg-PBA). We investigated hydrogel’s formation mechanism analyzed how component variations affect its morphological rheological properties. Our findings demonstrate that optimal Alg-PBA PVA weight ratio 2:1 yields superior mechanical strength. Glutathione (GSH) studies confirmed pronounced behavior. Furthermore, biocompatibility assessments revealed loaded 100 μg/mL GSH exhibited excellent compatibility significantly inhibited apoptosis under oxygen-glucose deprivation (OGD) conditions. work presents promising strategy for treating inflammation-related diseases provides valuable insights designing next-generation hydrogels adapt injury-responsive microenvironments.

Язык: Английский

Development of a ROS-responsive, glutathione-functionalized injectable hydrogel system for controlled drug release DOI
Kai Hu,

Linlin Liang,

Jian Song

и другие.

Journal of Biomaterials Applications, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Oxidative stress arises from an imbalance between excessive production of reactive oxygen species (ROS) and the body’s antioxidant defenses. In neurodegenerative diseases, this leads to ROS accumulation, causing neuronal dysfunction cell death. Traditional drug therapies often fail address dynamic nature neuroinflammation, limiting their therapeutic efficacy. To overcome challenge, we have developed innovative ROS-responsive injectable hydrogel. This hydrogel is designed detect oxidative sensitively release glutathione in a controlled manner, thereby modulating inflammation restoring damaged immune microenvironment facilitate tissue repair. The was synthesized by crosslinking polyvinyl alcohol (PVA) with sodium alginate modified 3-aminophenylboronic acid (Alg-PBA). We investigated hydrogel’s formation mechanism analyzed how component variations affect its morphological rheological properties. Our findings demonstrate that optimal Alg-PBA PVA weight ratio 2:1 yields superior mechanical strength. Glutathione (GSH) studies confirmed pronounced behavior. Furthermore, biocompatibility assessments revealed loaded 100 μg/mL GSH exhibited excellent compatibility significantly inhibited apoptosis under oxygen-glucose deprivation (OGD) conditions. work presents promising strategy for treating inflammation-related diseases provides valuable insights designing next-generation hydrogels adapt injury-responsive microenvironments.

Язык: Английский

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