Protection and waning of vaccine-induced, natural and hybrid immunity to SARS-CoV-2 in Hong Kong

Expert Review of Vaccines, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

As the COVID-19 pandemic transitions into its fourth year, understanding dynamics of immunity is critical for implementing effective public health measures. This study examines vaccine-induced, natural, and hybrid to SARS-CoV-2 in Hong Kong, focusing on their protective effectiveness waning characteristics against infection during Omicron BA.1/2 dominant period. We conducted a territory-wide retrospective cohort using vaccination records from Kong Department Health. The analysis included over 6.5 million adults, applying Andersen-Gill model estimate while addressing selection bias through inverse probability weighting. Vaccine-induced peaked one month after first dose but waned rapidly, boosters significantly prolonged protection. Infection-induced showed higher initial declined faster than vaccine-induced immunity. Hybrid provided most durable mRNA vaccines (Comirnaty) demonstrated greater slower compared inactivated (CoronaVac). represents strategy sustained protection SARS-CoV-2. Public policies should emphasize booster campaigns pathways enhance population-level guide future management Kong.

Язык: Английский

Estimation of trajectory of COVID-19 vaccines effectiveness against infection

Vaccine, Год журнала: 2025, Номер 55, С. 127067 - 127067

Опубликована: Март 31, 2025

Язык: Английский