Integration of Carboxylate Carbon Dot-Supported Gold Nanoparticles with Boron Nitride Nanosheets for Electrochemical Sensing of Prostate-Specific Antigen via Sandwich Immunoassays DOI
So Eun Kim,

Kathannan Sankar,

Jae Chol Yoon

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

An electrochemical sandwich immunoassay was fabricated to measure the prostate-specific antigen (PSA) biomarker. The PSA immunosensor developed by altering surface of a glassy carbon electrode (GCE) with nanocomposite comprising carboxyl-functionalized dots that support gold nanoparticles (AuNPs), which were then combined hydroxylated boron nitride nanosheets (HO-BN). This construction possesses distinctive signal enhancement characteristics and prepared via facile method. Considering high biological affinity AuNPs for biomolecules, (CDs) carboxyl (COOH) groups make suitable substrate modification. alteration allows antibody (Ab1) attachment, resulting in sandwich-like configuration. Additionally, dot-stabilized integrated into HO-BN nanosheet nanocomposites considerably boost electron transfer rate, leading remarkable potential sensor applications. By utilizing horseradish peroxidase (HRP)-conjugated antifree (Ab2), reduction hydrogen peroxide (H2O2) achieved within cell. led increased current, attributed concentration, is required biosensor analysis perform properly. revealed linear correlation concentrations ranging from 1.0 3500 pg mL-1, achieving low detection limit 0.136 mL-1. Furthermore, aptasensor demonstrates excellent selectivity, stability, commendable reproducibility, indicating its significant clinical research diagnostic

Язык: Английский

Porphyrinic metal-organic framework PCN-224 supported Prussian blue enables selective detection of casein and phytic acid DOI
Zhiqiang Zhou, Xiao Zhang, Wenting Chen

и другие.

Talanta, Год журнала: 2025, Номер unknown, С. 128121 - 128121

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Integration of Carboxylate Carbon Dot-Supported Gold Nanoparticles with Boron Nitride Nanosheets for Electrochemical Sensing of Prostate-Specific Antigen via Sandwich Immunoassays DOI
So Eun Kim,

Kathannan Sankar,

Jae Chol Yoon

и другие.

ACS Applied Bio Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

An electrochemical sandwich immunoassay was fabricated to measure the prostate-specific antigen (PSA) biomarker. The PSA immunosensor developed by altering surface of a glassy carbon electrode (GCE) with nanocomposite comprising carboxyl-functionalized dots that support gold nanoparticles (AuNPs), which were then combined hydroxylated boron nitride nanosheets (HO-BN). This construction possesses distinctive signal enhancement characteristics and prepared via facile method. Considering high biological affinity AuNPs for biomolecules, (CDs) carboxyl (COOH) groups make suitable substrate modification. alteration allows antibody (Ab1) attachment, resulting in sandwich-like configuration. Additionally, dot-stabilized integrated into HO-BN nanosheet nanocomposites considerably boost electron transfer rate, leading remarkable potential sensor applications. By utilizing horseradish peroxidase (HRP)-conjugated antifree (Ab2), reduction hydrogen peroxide (H2O2) achieved within cell. led increased current, attributed concentration, is required biosensor analysis perform properly. revealed linear correlation concentrations ranging from 1.0 3500 pg mL-1, achieving low detection limit 0.136 mL-1. Furthermore, aptasensor demonstrates excellent selectivity, stability, commendable reproducibility, indicating its significant clinical research diagnostic

Язык: Английский

Процитировано

0