Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis DOI Creative Commons
Jian Mei, Niqin Xiao, Yujiang Xi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 27, 2025

Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degradation of ECM and cartilage degeneration. Articular maintained chondrocytes, which secrete ECM, making stability these cells crucial for function. Research has shown that in later stages OA, cavities form, indicating decline chondrocyte Chondrocyte death considered central feature Apoptosis, form programmed cell death, plays key role this process. While controlled apoptosis helps remove damaged chondrocytes protects from injury, excessive disrupts balance microenvironment accelerates OA progression. Therefore, regulating may offer novel approach preventing treating This review examines pathways, interaction between regulatory factors apoptosis, analyzes current drug interventions targeting both preclinical clinical studies. It also discusses challenges outlines future research directions to guide upcoming

Язык: Английский

Regulation of apoptosis and interaction with cartilage degeneration in osteoarthritis DOI Creative Commons
Jian Mei, Niqin Xiao, Yujiang Xi

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 27, 2025

Osteoarthritis (OA) is a chronic degenerative joint disease, primarily characterized by the degradation of ECM and cartilage degeneration. Articular maintained chondrocytes, which secrete ECM, making stability these cells crucial for function. Research has shown that in later stages OA, cavities form, indicating decline chondrocyte Chondrocyte death considered central feature Apoptosis, form programmed cell death, plays key role this process. While controlled apoptosis helps remove damaged chondrocytes protects from injury, excessive disrupts balance microenvironment accelerates OA progression. Therefore, regulating may offer novel approach preventing treating This review examines pathways, interaction between regulatory factors apoptosis, analyzes current drug interventions targeting both preclinical clinical studies. It also discusses challenges outlines future research directions to guide upcoming

Язык: Английский

Процитировано

0