Correlation between levels of clock protein expression and effects on temozolomide-resistant glioblastoma and tumor progression

Human Cell, Год журнала: 2025, Номер 38(3)

Опубликована: Март 24, 2025

Язык: Английский

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Electrospun and 3D printed scaffolds based on biocompatible polymers for 3D cultivation of glioblastoma cells in vitro

Annals of 3D Printed Medicine, Год журнала: 2024, Номер 15, С. 100161 - 100161

Опубликована: Июнь 22, 2024

Additive manufacturing techniques capable of fabricating biocompatible scaffolds with a given submicron/micron/supramicron structure are growing interest for biomedical applications, including tissue engineering and tumor biology studies. Here, we propose antisolvent 3D printing electrospinning to obtain biopolymer different structural, mechanical, surface properties compare the cultivation patterns glioblastoma cells. We found that human G01 cells, derived from tissue, were able colonize in time-dependent manner; cells showed high viability as confirmed by colorimetric MTT assay, confocal fluorescence microscopy, scanning electron microscopy data. Electrospun collagen (low porosity, thin 2.75±0.22 μm fibers, low Young's modulus 0.076±0.033 MPa) provided monolayer-like growth dense cell-cell contacts, while 3D-printed PLGA (high thick ∼150 µm 18±2 stimulated glioblastoma-specific spindle-like morphology. All non-toxic maintained cell at least 2 weeks. The developed could be further used research model vitro or brain injury.

Язык: Английский

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Histone acetyltransferases as promising therapeutic targets in glioblastoma resistance

Cancer Letters, Год журнала: 2024, Номер unknown, С. 217269 - 217269

Опубликована: Сен. 1, 2024

Язык: Английский

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Regular exercise suppresses steatosis‐associated liver cancer development by degrading E2F1 and c‐Myc via circadian gene upregulation

Genes to Cells, Год журнала: 2024, Номер 29(11), С. 1012 - 1025

Опубликована: Окт. 2, 2024

Abstract Regular exercise is believed to suppress cancer progression. However, the precise molecular mechanisms by which prevents development remain unclear. In this study, using a steatosis‐associated liver mouse model, we found that regular at speed of 18 m/min for 20 min daily suppressed development. To explore underlying mechanisms, examined gene expression profiles in livers and non‐exercise groups. The expressions circadian genes, such as Per1 Cry2, were upregulated group. As rhythm disruption known cause various diseases, including cancer, improving through could contribute prevention. We further series E2F1 c‐Myc target genes directly affect proliferation cells was downregulated transcriptionally unchanged but degraded post‐translational level exercise. regulated Skp1‐Cul1‐FBXL3 (SCF FBXL3 ) ubiquitin ligase complex binding FBXL3, can form with c‐Myc, think mechanism degrade them. Our study revealed previously unknown

Язык: Английский

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Discovery of Arene Ruthenium(II) Complexes as Potential VEGF Inhibitors for Glioblastoma Metastasis Suppression

Journal of Medicinal Chemistry, Год журнала: 2024, Номер 67(21), С. 18724 - 18740

Опубликована: Окт. 21, 2024

Developing drugs for treating glioblastoma has been a significant challenge. Herein, series of arene ruthenium(II) complexes have synthesized and investigated as potential candidates to suppress the proliferation metastasis glioblastoma. It is found that para-substituent-modified molecules, especially 6, exhibit higher antitumor activity than ortho-substituents. Further studies show 6 can trigger tumor cell autophagy by regulating PI3K/AKT/mTOR pathway. Moreover, it also induce DNA damage in cells through binding stabilizing VEGF G-quadruplex DNA. Furthermore, confirmed inhibit U87-MG situ xenograft zebrafish model. Hence, be developed promising therapeutic agents treatment future.

Язык: Английский

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Circadian rhythms in haematological malignancies: therapeutic potential and personalised interventions

EBioMedicine, Год журнала: 2024, Номер 110, С. 105451 - 105451

Опубликована: Ноя. 19, 2024

Язык: Английский

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