Multiple Atropo Selectivity by κ2‐N,O‐Oxazoline Urea Ligands in Cobaltaelectro‐Catalyzed C─H Activations: Decoding Selectivity with Data Science Integration DOI Creative Commons
Philipp Boos, Neeraj Kumar Pandit, Suman Dana

и другие.

ChemistryEurope, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Enantioselective catalysis is one of the most prominent strategies in organic synthesis to access chiral bioactive compounds and advanced materials. Particularly, development ligands has significantly efficiency selectivity transition metal‐catalyzed enantioselective transformations. Over recent decades, numerous ligand classes with distinct geometrical electronic properties have been established. Despite these advances, demand for novel, tunable, highly effective persists, driven by need structurally diverse molecules pursuit greener, more sustainable catalytic processes. Herein, a novel class oxazoline ureas introduced their potential as κ 2 ‐ N , O ‐preligands metal demonstrated. The urea are featurized compared amide enol derivatives using physical descriptors. A multivariate linear regression model constructed quantitatively describe effect quinoline fragment from substrate on enantioselectivity. Moreover, effectively applied atropo‐enantioselective cobaltaelectro‐catalyzed C─H annulations 1‐alkynyl indoles.

Язык: Английский

Multiple Atropo Selectivity by κ2‐N,O‐Oxazoline Urea Ligands in Cobaltaelectro‐Catalyzed C─H Activations: Decoding Selectivity with Data Science Integration DOI Creative Commons
Philipp Boos, Neeraj Kumar Pandit, Suman Dana

и другие.

ChemistryEurope, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Enantioselective catalysis is one of the most prominent strategies in organic synthesis to access chiral bioactive compounds and advanced materials. Particularly, development ligands has significantly efficiency selectivity transition metal‐catalyzed enantioselective transformations. Over recent decades, numerous ligand classes with distinct geometrical electronic properties have been established. Despite these advances, demand for novel, tunable, highly effective persists, driven by need structurally diverse molecules pursuit greener, more sustainable catalytic processes. Herein, a novel class oxazoline ureas introduced their potential as κ 2 ‐ N , O ‐preligands metal demonstrated. The urea are featurized compared amide enol derivatives using physical descriptors. A multivariate linear regression model constructed quantitatively describe effect quinoline fragment from substrate on enantioselectivity. Moreover, effectively applied atropo‐enantioselective cobaltaelectro‐catalyzed C─H annulations 1‐alkynyl indoles.

Язык: Английский

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