Prediction of Hippocampal Signals in Mice Using a Deep Learning Approach for Neurohybrid Technology Applications

Algorithms, Год журнала: 2024, Номер 17(6), С. 252 - 252

Опубликована: Июнь 7, 2024

The increasing growth in knowledge about the functioning of nervous system mammals and humans, as well significant neuromorphic technology developments recent decades, has led to emergence a large number brain–computer interfaces neuroprosthetics for regenerative medicine tasks. Neurotechnologies have traditionally been developed therapeutic purposes help or replace motor, sensory cognitive abilities damaged by injury disease. They also potential memory enhancement. However, there are still no fully neurotechnologies neural capable restoring expanding functions, particular memory, humans. In this regard, search new technologies field restoration functions is an urgent task modern neurophysiology, neurotechnology artificial intelligence. hippocampus important brain structure connected information processing brain. aim paper propose approach based on deep networks prediction hippocampal signals CA1 region received biological input CA3 region. We compare results two widely used architectures: reservoir computing (RC) long short-term (LSTM) networks. proposed study can be viewed first step complex development neurohybrid chip, which allows one restore rodent hippocampus.

Язык: Английский

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A Speech Neuroprosthesis in the Frontal Lobe and Hippocampus: Decoding High-Frequency Activity into Phonemes

Neurosurgery, Год журнала: 2024, Номер unknown

Опубликована: Июнь 27, 2024

BACKGROUND AND OBJECTIVES: Loss of speech due to injury or disease is devastating. Here, we report a novel neuroprosthesis that artificially articulates building blocks based on high-frequency activity in brain areas never harnessed for before: anterior cingulate and orbitofrontal cortices, hippocampus. METHODS: A 37-year-old male neurosurgical epilepsy patient with intact speech, implanted depth electrodes clinical reasons only, silently controlled the almost immediately natural way voluntarily produce 2 vowel sounds. RESULTS: During first set trials, participant made different sounds 85% accuracy. In following performance improved consistently, which may be attributed neuroplasticity. We show trained overt data silently. CONCLUSION: This open strategy implantation at earlier stages (eg, amyotrophic lateral sclerosis), while intact, training still allows silent control later stages. The results demonstrate feasibility direct decoding includes spiking aforementioned production phonemes serve as part replacing lost pathways.

Язык: Английский

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Flexible and stretchable synaptic devices for wearable neuromorphic electronics

Flexible and Printed Electronics, Год журнала: 2023, Номер 8(4), С. 043001 - 043001

Опубликована: Ноя. 7, 2023

Abstract Wearable neuromorphic devices have gained attention because of the growth in Internet Things and increasing demand for health monitoring. They provide meaningful information interact with external environment through physiological signal processing seamless interaction human body. The concept these originated from development flexible/stretchable electronics, which offer a solution to limitation conventional rigid devices. been developed mimic synaptic functions flexibility/stretchability biological nervous system. In this study, we described various properties that should be implemented operating mechanisms exhibit respect two- three-terminal Further, specified comprehensive methods implementing mechanical flexibility stretchability electronics both structure material engineering. addition, explored wearable applications devices, such as sensors danger detection, auxiliary equipment people sensory disabilities, neuroprosthetic We expect review an overall understanding concepts trends flexible stretchable potential extensions state-of-the-art cybernetics exoskeleton.

Язык: Английский

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Applications of Bioengineered Polymer in the Field of Nano-Based Drug Delivery

ACS Omega, Год журнала: 2023, Номер 9(1), С. 81 - 96

Опубликована: Дек. 18, 2023

The most favored route of drug administration is oral administration; however, several factors, including poor solubility, low bioavailability, and degradation, in the severe gastrointestinal environment frequently compromise effectiveness drugs taken orally. Bioengineered polymers have been developed to overcome these difficulties enhance delivery therapeutic agents. Polymeric nanoparticles, carbon dots, fullerenes, quantum emerged as crucial components this context. They provide a novel way deliver various materials, proteins, vaccine antigens, medications, precisely locations where they are supposed an effect. promise integrated strategy, which combines nanoparticles with bioengineered polymers, address drawbacks conventional medication such early degradation. In recent years, we seen substantially increased interest because their distinctive qualities, biocompatibility, biodegradability, flexible physicochemical characteristics. different chitosan, alginate, poly(lactic-co-glycolic acid), can shield medications or antigens from degradation unfavorable conditions aid orally through mucosal lower cytotoxicity, thus used targeted delivery. Future research area should focus on optimizing properties improve performance carriers.

Язык: Английский

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The extended mind thesis and the cognitive artifacts approach: A comparison

Developments in neuroethics and bioethics, Год журнала: 2024, Номер unknown, С. 167 - 189

Опубликована: Янв. 1, 2024

Язык: Английский

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