Defining overlooked structures reveals new associations between cortex and cognition in aging and Alzheimer's disease

Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. e1714232024 - e1714232024

Опубликована: Фев. 21, 2024

Recent work suggests that indentations of the cerebral cortex, or sulci, may be uniquely vulnerable to atrophy in aging and Alzheimer's disease (AD) posteromedial cortex (PMC) is particularly pathology accumulation. However, these studies did not consider small, shallow, variable tertiary sulci are located association cortices often associated with human-specific aspects cognition. Here, we manually defined 4,362 PMC 432 hemispheres 216 human participants (50.5% female) found smaller putative showed more age- AD-related thinning than larger, consistent strongest effects for two newly uncovered sulci. A model-based approach relating sulcal morphology cognition identified a subset was most memory executive function scores older adults. These findings lend support retrogenesis hypothesis linking brain development aging, provide new neuroanatomical targets future AD. Significance Statement Large-scale changes cortical structure suggest atrophy. smallest individually folds cognitive development, have been studied aging. investigate first time (AD). We find shallower show larger (PMC), classical theories developmental trajectories at novel anatomical resolution insight into relationships between individual differences structural decline.

Язык: Английский

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Sulcal variability in anterior lateral prefrontal cortex contributes to variability in reasoning performance among young adults

Brain Structure and Function, Год журнала: 2024, Номер 229(2), С. 387 - 402

Опубликована: Янв. 6, 2024

Язык: Английский

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Ventral temporal and posteromedial sulcal morphology in autism spectrum disorder

Neuropsychologia, Год журнала: 2024, Номер 195, С. 108786 - 108786

Опубликована: Янв. 4, 2024

Язык: Английский

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The Chimpanzee Brainnetome Atlas reveals distinct connectivity and gene expression profiles relative to humans

The Innovation, Год журнала: 2025, Номер 6(2), С. 100755 - 100755

Опубликована: Янв. 6, 2025

Chimpanzees (Pan troglodytes) are one of humans' closest living relatives, making them the most directly relevant comparison point for understanding human brain evolution. Zeroing in on differences connectivity between humans and chimpanzees can provide key insights into specific evolutionary changes that might have occurred along lineage. However, such comparisons hindered by absence cross-species atlases established within same framework. To address this gap, we developed Chimpanzee Brainnetome Atlas (ChimpBNA) using a connectivity-based parcellation Leveraging new resource, found substantial divergence patterns two species across association cortices, notably lateral temporal dorsolateral prefrontal cortex. These deviate sharply from pattern cortical expansion observed when comparing to chimpanzees, highlighting more complex nuanced evolution than previously recognized. Additionally, identified regions displaying connectional asymmetries differed species, likely resulting divergence. Genes highly expressed divergent connectivities were enriched cell types crucial projection circuits synapse formation, whose pronounced expression hint at genetic influences neural circuit development, function, Our study provides fine-scale chimpanzee atlas highlights chimpanzee-human rigorous comparative manner. In addition, these results suggest potential gene correlates species-specific linking neuroimaging data, offering human-unique cognitive capabilities.

Язык: Английский

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Sulcal morphology of posteromedial cortex substantially differs between humans and chimpanzees

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Июнь 1, 2023

Abstract Recent studies identify a surprising coupling between evolutionarily new sulci and the functional organization of human posteromedial cortex (PMC). Yet, no study has compared this modern PMC sulcal patterning humans non-human hominoids. To fill gap in knowledge, we first manually defined over 2500 120 chimpanzee ( Pan Troglodytes ) hemispheres 144 hemispheres. We uncovered four sulci, quantitatively identified species differences incidence, depth, surface area. Interestingly, some are more common others, chimpanzees. Further, found that prominent marginal ramus cingulate sulcus differs significantly species. Contrary to classic observations, present results reveal anatomy substantially chimpanzees—findings which lay foundation for better understanding evolution neuroanatomical-functional neuroanatomical-behavioral relationships highly expanded region cerebral cortex.

Язык: Английский

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The spatiotemporal dynamics of semantic integration in the human brain

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Окт. 24, 2023

Language depends critically on the integration of lexical information across multiple words to derive semantic concepts. Limitations spatiotemporal resolution have previously rendered it difficult isolate processes involved in integration. We utilized intracranial recordings epilepsy patients (n = 58) who read written word definitions. Descriptions were either referential or non-referential a common object. Semantically sentences enabled high frequency broadband gamma activation (70-150 Hz) inferior frontal sulcus (IFS), medial parietal cortex, orbitofrontal cortex (OFC) and temporal lobe left, language-dominant hemisphere. IFS, OFC posterior middle gyrus activity was modulated by coherence sentences, exposing effects that independent task-based status. Components this network, alongside superior sulcus, engaged for did not clearly reduce search space final word. These results indicate existence complementary cortical mosaics cortex.

Язык: Английский

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Neuroanatomical and Functional Dissociations between Variably Present Anterior Lateral Prefrontal Sulci

Journal of Cognitive Neuroscience, Год журнала: 2023, Номер 35(11), С. 1846 - 1867

Опубликована: Янв. 1, 2023

The lateral prefrontal cortex (LPFC) is an evolutionarily expanded region in humans that critical for numerous complex functions, many of which are largely hominoid specific. Although recent work shows the presence or absence specific sulci anterior LPFC associated with cognitive performance across age groups, it unknown whether these structures relates to individual differences functional organization LPFC. To fill this gap knowledge, we leveraged multimodal neuroimaging data from two samples encompassing 82 young adult (aged 22-36 years) and show dorsal ventral components paraintermediate frontal sulcus, pimfs, present distinct morphological (surface area), architectural (thickness myelination), (resting-state connectivity networks) properties. We further contextualize pimfs within classic modern cortical parcellations. Taken together, mark transitions anatomy function, metrics These results emphasize a structure consider when examining anatomical suggest future individual-level parcellations could benefit incorporating sulcal delineating regions.

Язык: Английский

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Cognitive Archeology and the Attentional System: An Evolutionary Mismatch for the Genus Homo

Journal of Intelligence, Год журнала: 2023, Номер 11(9), С. 183 - 183

Опубликована: Сен. 12, 2023

Brain evolution is a key topic in evolutionary anthropology. Unfortunately, this sense the fossil record can usually support limited anatomical and behavioral inferences. Nonetheless, information from species is, any case, particularly valuable, because it represents only direct proof of cerebral changes throughout human phylogeny. Recently, archeology psychology have been integrated field cognitive archeology, which aims to interpret current models according evidence we on extinct species. In article, such reviewed order consider whether what extent archeological supply regarding attentional system different taxa genus. particular, correlates associated with fronto-parietal working memory are employed recent our species, Homo sapiens, mismatch between visuospatial ability hypothesized. These two functional systems present-moment awareness mind-wandering, respectively, their unbalance explain structural sensitivity psychological distress

Язык: Английский

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Dissociable contributions of the medial parietal cortex to recognition memory

Journal of Neuroscience, Год журнала: 2024, Номер unknown, С. e2220232024 - e2220232024

Опубликована: Март 25, 2024

Human neuroimaging studies of episodic memory retrieval routinely observe the engagement specific cortical regions beyond medial temporal lobe. Of these, parietal cortex (MPC) is particular interest given its distinct functional characteristics during different tasks. Specifically, while recognition and autobiographical recall tasks are both used to probe retrieval, these paradigms consistently drive spatial patterns response within MPC. However, other have emphasized alternate MPC dissociations in terms brain network connectivity profiles or stimulus category selectivity. As unique contributions remain unclear, adjudicating between accounts can provide better consensus regarding function. Therefore, we a precision-neuroimaging dataset (7T magnetic resonance imaging) examine how differentially engaged task-related may also reflect profiles. We observed interleaved, though spatially distinct, subregions where responses were sensitive either decisions semantic representation stimuli. In addition, this dissociation was further accentuated by displaying with hippocampus task rest. Finally, show that recent observations dissociable person place selectivity category-specific from identified mnemonic demands. Together, examining precision mapping individuals, data suggest previously conform common principle organization throughout hippocampal-neocortical systems.

Язык: Английский

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Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

Опубликована: Авг. 15, 2024

Recent work has uncovered relationships between evolutionarily new small and shallow cerebral indentations, or sulci, human behavior. Yet, this relationship remains unexplored in the lateral parietal cortex (LPC) parieto-occipital junction (LPOJ). After defining thousands of sulci a young adult cohort, we revised previous LPC/LPOJ sulcal landscape to include four previously overlooked, small, shallow, variable sulci. One these (ventral supralateral occipital sulcus, slocs-v) is present nearly every hemisphere morphologically, architecturally, functionally dissociable from neighboring A data-driven, model-based approach, relating depth behavior further revealed that morphology only subset including slocs-v, related performance on spatial orientation task. Our findings build classic neuroanatomical theories identify targets for future “precision imaging” studies exploring among brain structure, function, cognitive abilities individual participants.

Язык: Английский

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