The Journal of Physiological Sciences,
Год журнала:
2024,
Номер
74(1)
Опубликована: Авг. 2, 2024
Abstract
Many
experts
have
extensively
studied
the
potential
of
exercise
as
a
treatment
option
for
psychiatric
conditions,
including
depression
and
autism
spectrum
disorder
(ASD).
Despite
their
core
symptoms,
these
conditions
exhibits
comparable
component
traits,
an
anxiety.
In
this
study,
we
explored
effect
on
behavioral
abnormalities
in
focusing
its
intensity
emotional
resilience.
Shank3B
knockout
(KO
SED
)
mice
displaying
self-injurious
repetitive
behavior
C57BL/6J
mice,
susceptible
to
stress
ASD
model,
respectively,
were
subjected
moderate-intensity
(ME)
2
weeks.
ME
mitigated
symptoms
(excessive
grooming
traits
despair)
but
did
not
exert
significant
anxiolytic
effect.
Notably,
has
emerged
critical
determinant
efficacy,
evidenced
by
lower
ventilation
threshold
mediated
low-intensity
exercise.
The
findings
substantiate
notion
that
is
promising
disease-modifying
treatment,
matters
Graphical
Abstract
Closed
head
injury
is
a
prevalent
form
of
traumatic
brain
with
poorly
understood
effects
on
cortical
neural
circuits.
Given
the
emotional
and
behavioral
impairments
linked
to
closed
injury,
it
vital
uncover
functional
deficits
their
driving
mechanisms.
In
this
study,
we
employed
robust
viral
tracing
technique
identify
alteration
pathway
connecting
medial
prefrontal
cortex
basolateral
amygdala,
observed
disruptions
in
neuronal
projections
between
amygdala
following
injury.
Remarkably,
our
results
highlight
that
ZL006,
an
inhibitor
targeting
PSD-95/nNOS
interaction,
stands
out
for
its
ability
selectively
reverse
these
aberrations.
Specifically,
ZL006
effectively
mitigates
from
induced
by
Furthermore,
using
chemogenetic
approaches,
elucidate
activating
circuit
produces
anxiolytic
effects,
aligning
therapeutic
potential
ZL006.
Additionally,
administration
astrocyte
activation,
leading
restoration
glutamatergic
neuron
activity.
Moreover,
context
attenuating
anxiety-like
behaviors
through
treatment,
observe
reduction
injury–induced
engulfment,
which
may
correlate
decrease
dendritic
spine
density
neurons.
The Journal of Physiological Sciences,
Год журнала:
2024,
Номер
74(1)
Опубликована: Авг. 2, 2024
Abstract
Many
experts
have
extensively
studied
the
potential
of
exercise
as
a
treatment
option
for
psychiatric
conditions,
including
depression
and
autism
spectrum
disorder
(ASD).
Despite
their
core
symptoms,
these
conditions
exhibits
comparable
component
traits,
an
anxiety.
In
this
study,
we
explored
effect
on
behavioral
abnormalities
in
focusing
its
intensity
emotional
resilience.
Shank3B
knockout
(KO
SED
)
mice
displaying
self-injurious
repetitive
behavior
C57BL/6J
mice,
susceptible
to
stress
ASD
model,
respectively,
were
subjected
moderate-intensity
(ME)
2
weeks.
ME
mitigated
symptoms
(excessive
grooming
traits
despair)
but
did
not
exert
significant
anxiolytic
effect.
Notably,
has
emerged
critical
determinant
efficacy,
evidenced
by
lower
ventilation
threshold
mediated
low-intensity
exercise.
The
findings
substantiate
notion
that
is
promising
disease-modifying
treatment,
matters
Graphical
