Neural correlates of obesity across the lifespan
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Май 28, 2024
Abstract
Associations
between
brain
and
obesity
are
bidirectional:
changes
in
structure
function
underpin
over-eating,
while
chronic
adiposity
leads
to
atrophy.
Investigating
brain-obesity
interactions
across
the
lifespan
can
help
better
understand
these
relationships.
This
study
explores
interaction
cortical
morphometry
children,
young
adults,
older
adults.
We
also
investigate
genetic,
neurochemical,
cognitive
correlates
of
associations.
Our
findings
reveal
a
pattern
lower
thickness
fronto-temporal
regions
associated
with
all
age
cohorts
varying
age-dependent
patterns
remaining
regions.
In
adults
neurochemical
expression
inflammatory
mitochondrial
genes.
children
is
modifications
involved
emotional
attentional
processes.
Thus,
might
originate
from
during
early
adolescence,
leading
neurodegeneration
later
life
through
mechanisms.
Язык: Английский
Repeated net-tDCS of the hypothalamus appetite-control network enhances inhibitory control and decreases sweet food intake in persons with overweight or obesity
Brain stimulation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Working memory gating in obesity is moderated by striatal dopaminergic gene variants
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Фев. 23, 2024
Everyday
life
requires
an
adaptive
balance
between
distraction-resistant
maintenance
of
information
and
the
flexibility
to
update
this
when
needed.
These
opposing
mechanisms
are
proposed
be
balanced
through
a
working
memory
gating
mechanism.
Prior
research
indicates
that
obesity
may
elevate
risk
deficits,
yet
underlying
remain
elusive.
Dopaminergic
alterations
have
emerged
as
potential
mediator.
However,
current
models
suggest
these
should
only
shift
in
tasks,
not
produce
overall
deficits.
The
empirical
support
for
notion
is
currently
lacking,
however.
To
address
gap,
we
pooled
data
from
three
studies
(N
=
320)
where
participants
performed
task.
Higher
BMI
was
associated
with
poorer
memory,
irrespective
whether
there
need
maintain
or
information.
participants,
addition
level,
were
categorized
based
on
certain
putative
dopamine-signaling
characteristics
(single-nucleotide
polymorphisms
[SNPs];
specifically,
Taq1A
DARPP-32),
distinct
effects
emerged.
SNPs,
primarily
striatal
dopamine
transmission,
appear
linked
differences
updating,
among
high-BMI
individuals.
Moreover,
blood
amino
acid
ratio,
which
central
synthesis
capacity,
combined
shifted
distractor-resistant
updating.
findings
both
dopamine-dependent
dopamine-independent
cognitive
exist
obesity.
Understanding
crucial
if
aim
modify
maladaptive
profiles
individuals
Язык: Английский
Neurometabolic Profile in Obese Patients: A Cerebral Multivoxel Magnetic Resonance Study
Medicina,
Год журнала:
2024,
Номер
60(11), С. 1880 - 1880
Опубликована: Ноя. 16, 2024
Obesity-related
chronic
inflammation
may
lead
to
neuroinflammation
and
neurodegeneration.
This
study
aimed
evaluate
the
neurometabolic
profile
of
obese
patients
using
cerebral
multivoxel
magnetic
resonance
spectroscopy
(mvMRS)
assess
correlations
between
brain
metabolites
obesity
markers,
including
body
mass
index
(BMI),
waist
circumference,
waist-hip
ratio,
fat
percentage,
indicators
metabolic
syndrome
(e.g.,
triglycerides,
HDL
cholesterol,
fasting
blood
glucose,
insulin,
insulin
resistance
(HOMA-IR)).
Язык: Английский
Repeated net-tDCS of the hypothalamus appetite-control network reduces inhibitory control and sweet food intake in persons with overweight or obesity
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Abstract
Background
Reduced
inhibitory
control
is
associated
with
obesity
and
neuroimaging
studies
indicate
that
diminished
prefrontal
cortex
activity
influence
eating
behavior
metabolism.
The
hypothalamus
regulates
energy
homeostasis
functionally
connected
to
cortical
subcortical
regions
especially
the
frontal
areas.
Objectives
We
tested
network-targeted
transcranial
direct
current
stimulation
(net-tDCS)
excitability
of
brain
involved
in
appetite
control.
Methods
In
a
randomized,
double-blind
parallel
group
design,
44
adults
overweight
or
(BMI
30.6
kg/m
2
,
52.3
%
female)
received
active
(anodal
cathodal)
sham
12-channel
net-tDCS
on
appetite-control
network
for
25
minutes
three
consecutive
days
while
performing
Stop-Signal-Task
measure
response
inhibition.
Before
after
stimulation,
state
questionnaires
assessed
changes
desire
eat
food
craving.
Directly
participants
breakfast
buffet
evaluate
ad-libitum
intake.
An
oral
glucose
tolerance
test
was
conducted
at
follow-up.
Resting-state
functional
MRI
obtained
baseline
Results
Stop-Signal
Reaction
Time
(SSRT)
shorter
both
groups
versus
sham,
indicating
improved
Additionally,
stronger
increase
hypothalamic
connectivity
SSRT.
Caloric
intake
sweet
lower
anodal
but
no
main
effects
between
were
observed
total
macronutrient
intake,
craving
ratings
eat.
At
follow-up,
differences
peripheral
Conclusion
Our
study
suggests
modulating
patterns
via
may
improve
choice
Graphical
Highlights
Active
showed
better
compared
group.
Stronger
net-tDCS.
No
found
kilocaloric
Anodal
Язык: Английский
Working Memory Gating in Obesity is Moderated by Striatal Dopaminergic Gene Variants
Опубликована: Сен. 20, 2024
Everyday
life
requires
an
adaptive
balance
between
distraction-resistant
maintenance
of
information
and
the
flexibility
to
update
this
when
needed.
These
opposing
mechanisms
are
proposed
be
balanced
through
a
working
memory
gating
mechanism.
Prior
research
indicates
that
obesity
may
elevate
risk
deficits,
yet
underlying
remain
elusive.
Dopaminergic
alterations
have
emerged
as
potential
mediator.
However,
current
models
suggest
these
should
only
shift
in
tasks,
not
produce
overall
deficits.
The
empirical
support
for
notion
is
currently
lacking,
however.
To
address
gap,
we
pooled
data
from
three
studies
(N
=
320)
where
participants
performed
task.
Higher
BMI
was
associated
with
poorer
memory,
irrespective
whether
there
need
maintain
or
information.
participants,
addition
level,
were
categorized
based
on
certain
putative
dopamine-signaling
characteristics
(Single
Nucleotide
Polymorphisms;
specifically,
Taq1A
DARPP-32),
distinct
effects
emerged.
SNPs,
primarily
striatal
dopamine
transmission,
appear
linked
differences
updating,
among
high-BMI
individuals.
Moreover,
blood
amino
acid
ratio,
which
central
synthesis
capacity,
combined
BMI,
shifted
distractor-resistant
updating.
findings
both
dopamine-dependent
dopamine-independent
cognitive
exist
obesity.
Understanding
crucial
if
aim
modify
maladaptive
profiles
individuals
Язык: Английский
Working memory gating in obesity is moderated by striatal dopaminergic gene variants
eLife,
Год журнала:
2024,
Номер
13
Опубликована: Окт. 21, 2024
Everyday
life
requires
an
adaptive
balance
between
distraction-resistant
maintenance
of
information
and
the
flexibility
to
update
this
when
needed.
These
opposing
mechanisms
are
proposed
be
balanced
through
a
working
memory
gating
mechanism.
Prior
research
indicates
that
obesity
may
elevate
risk
deficits,
yet
underlying
remain
elusive.
Dopaminergic
alterations
have
emerged
as
potential
mediator.
However,
current
models
suggest
these
should
only
shift
in
tasks,
not
produce
overall
deficits.
The
empirical
support
for
notion
is
currently
lacking,
however.
To
address
gap,
we
pooled
data
from
three
studies
(N
=
320)
where
participants
performed
task.
Higher
BMI
was
associated
with
poorer
memory,
irrespective
whether
there
need
maintain
or
information.
participants,
addition
level,
were
categorized
based
on
certain
putative
dopamine-signaling
characteristics
(single-nucleotide
polymorphisms
[SNPs];
specifically,
Taq1A
DARPP-32),
distinct
effects
emerged.
SNPs,
primarily
striatal
dopamine
transmission,
appear
linked
differences
updating,
among
high-BMI
individuals.
Moreover,
blood
amino
acid
ratio,
which
central
synthesis
capacity,
combined
shifted
distractor-resistant
updating.
findings
both
dopamine-dependent
dopamine-independent
cognitive
exist
obesity.
Understanding
crucial
if
aim
modify
maladaptive
profiles
individuals
Язык: Английский
Spinal afferent neurons: emerging regulators of energy balance and metabolism
Frontiers in Molecular Neuroscience,
Год журнала:
2024,
Номер
17
Опубликована: Ноя. 8, 2024
Recent
advancements
in
neurophysiology
have
challenged
the
long-held
paradigm
that
vagal
afferents
serve
as
primary
conduits
for
physiological
signals
governing
food
intake
and
energy
expenditure.
An
expanding
body
of
evidence
now
illuminates
critical
role
spinal
afferent
neurons
these
processes,
necessitating
a
reevaluation
our
understanding
homeostasis
regulation.
This
comprehensive
review
synthesizes
cutting-edge
research
elucidating
multifaceted
functions
maintaining
metabolic
equilibrium.
Once
predominantly
associated
with
nociception
pathological
states,
are
recognized
integral
components
intricate
network
regulating
feeding
behavior,
nutrient
sensing,
balance.
We
explore
how
contribute
to
satiation
signaling
meal
termination
through
complex
gut-brain
axis
pathways.
The
also
delves
into
developing
play
crucial
expenditure
ability
neuronal
fibers
carry
can
modulate
behavior
well
adaptive
thermogenesis
adipose
tissue
influencing
basal
rate,
thereby
contributing
overall
analysis
not
only
challenges
existing
paradigms
but
opens
new
avenues
therapeutic
interventions
suggesting
potential
targets
treating
disorders.
In
conclusion,
this
highlights
need
shift
homeostasis,
positioning
key
players
web
Язык: Английский
Association of early life cardiovascular risk factors with grey matter structure in young adults in the United Kingdom: the ALSPAC study
EBioMedicine,
Год журнала:
2024,
Номер
110, С. 105490 - 105490
Опубликована: Дек. 1, 2024
Язык: Английский
Working Memory Gating in Obesity is Moderated by Striatal Dopaminergic Gene Variants
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 6, 2023
Abstract
Everyday
life
requires
an
adaptive
balance
between
distraction-resistant
maintenance
of
information
and
the
flexibility
to
update
this
when
needed.
These
opposing
mechanisms
are
proposed
be
balanced
through
a
working
memory
gating
mechanism.
Prior
research
indicates
that
obesity
may
elevate
risk
deficits,
yet
underlying
remain
elusive.
Dopaminergic
alterations
have
emerged
as
potential
mediator.
However,
current
models
suggest
these
should
only
shift
in
tasks,
not
produce
overall
deficits.
The
empirical
support
for
notion
is
currently
lacking,
however.
To
address
gap,
we
pooled
data
from
three
studies
(N
=
320)
where
participants
performed
task.
Higher
BMI
was
associated
with
poorer
memory,
irrespective
whether
there
need
maintain
or
information.
participants,
addition
level,
were
categorized
based
on
certain
putative
dopamine-signaling
characteristics
(Single
Nucleotide
Polymorphisms;
specifically,
Taq1A
DARPP-32),
distinct
effects
emerged.
SNPs,
primarily
striatal
dopamine
transmission,
appear
linked
differences
updating,
among
high-BMI
individuals.
Moreover,
blood
amino
acid
ratio,
which
central
synthesis
capacity,
combined
BMI,
shifted
distractor-resistant
updating.
findings
both
dopamine-dependent
dopamine-independent
cognitive
exist
obesity.
Understanding
crucial
if
aim
modify
maladaptive
profiles
individuals
Язык: Английский