Identifying key palmitoylation-associated genes in endometriosis through genomic data analysis

BMC Women s Health, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 5, 2025

Palmitoylation, a post-translational lipid modification, has garnered increasing attention for its role in inflammatory processes and tumorigenesis. Emerging evidence suggests potential association between palmitoylation responses the pathogenesis of endometriosis. However, precise mechanistic interplay remains elusive, necessitating further investigation. This study integrated transcriptomic analysis Mendelian randomization (MR) to identify causal gene set implicated Differentially expressed genes (DEGs) were first identified training dataset using limma package R. Weighted co-expression network (WGCNA) was subsequently performed, leveraging Single Sample Gene Set Enrichment Analysis (ssGSEA)-derived scores palmitoylation-related (PRGs) as phenotypic traits key modular genes. The intersection these with DEGs yielded refined set. Machine learning algorithms then applied optimize selection, followed by external validation, immune infiltration analysis, RNA construction, exploration targeted drug candidates. Through rigorous screening process, VRK1, GALNT12, RMI1 emerged associated palmitoylation, exhibiting significant downregulation endometriosis samples (P < 0.05), indicative protective role. Immune revealed strong correlations M2 macrophages well resting Natural Killer (NK) cells. Additionally, investigations into profiling provided novel insights, laying groundwork future high-quality validation studies. employed comprehensive analytical framework palmitoylation-associated integration immunoinfiltration offers valuable insights advancing clinical diagnostics, disease monitoring, therapeutic development

Язык: Английский

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The role of miR-21 as a biomarker and therapeutic target in cardiovascular disease

Clinica Chimica Acta, Год журнала: 2025, Номер unknown, С. 120304 - 120304

Опубликована: Апрель 1, 2025

Язык: Английский

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MiR-1 alleviates chronic heart failure through HCN2/HCN4 axis in vitro

Tissue and Cell, Год журнала: 2025, Номер unknown, С. 102921 - 102921

Опубликована: Апрель 1, 2025

Язык: Английский

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Modeling heart failure by induced pluripotent stem cell-derived organoids.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Год журнала: 2025, Номер unknown, С. 167861 - 167861

Опубликована: Апрель 1, 2025

Язык: Английский

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