Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank DOI Creative Commons
Valentina Paz,

Hannah Wilcox,

Matthew Goodman

и другие.

Sleep Health, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Sleep is a complex behavior regulated by genetic and environmental factors impacting disease outcomes. However, the effect of multidimensional sleep encompassing several dimensions on common diseases, specifically mental health disorders, has yet to be fully elucidated. Using Mass General Brigham Biobank, we examined association with outcomes investigated whether behaviors modulate predisposition unfavorable diseases. We generated Polygenic Health Score using previously identified single nucleotide polymorphisms constructed Lifestyle Index based self-reported questions electronic records; tested their association; performed phenome-wide analyses between these indexes clinical phenotypes; analyzed interaction prevalent A total 15,884 participants were included in analysis (mean age 54.4; 58.6% female). The was associated (β=0.050, 95% CI=0.032, 0.068) 114 spanning 12 groups, including obesity, sleep, substance use (p<3.3×10-5). 458 17 mood, anxiety (p<5.1×10-5). 108 both indexes, groups. No interactions found Favorable healthy may independently protect against disease, underscoring impact population need for prevention strategies focused habits.

Язык: Английский

Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank DOI Creative Commons
Valentina Paz,

Hannah Wilcox,

Matthew Goodman

и другие.

Sleep Health, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Sleep is a complex behavior regulated by genetic and environmental factors impacting disease outcomes. However, the effect of multidimensional sleep encompassing several dimensions on common diseases, specifically mental health disorders, has yet to be fully elucidated. Using Mass General Brigham Biobank, we examined association with outcomes investigated whether behaviors modulate predisposition unfavorable diseases. We generated Polygenic Health Score using previously identified single nucleotide polymorphisms constructed Lifestyle Index based self-reported questions electronic records; tested their association; performed phenome-wide analyses between these indexes clinical phenotypes; analyzed interaction prevalent A total 15,884 participants were included in analysis (mean age 54.4; 58.6% female). The was associated (β=0.050, 95% CI=0.032, 0.068) 114 spanning 12 groups, including obesity, sleep, substance use (p<3.3×10-5). 458 17 mood, anxiety (p<5.1×10-5). 108 both indexes, groups. No interactions found Favorable healthy may independently protect against disease, underscoring impact population need for prevention strategies focused habits.

Язык: Английский

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