A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment DOI Creative Commons

Zixuan Xiong,

Yi‐Chun Huang,

Shulong Cao

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 12, 2025

Advanced ovarian cancer (AOC) is prone to recurrence, which can be attributed drug resistance. Drug resistance may related the tumor microenvironment (TME), including immune and non-immune TME. In TME, effector cells such as dendritic (DCs), M1-like tumor-associated macrophages (M1-TAMs), T are inhibited. contrast, immunosuppressive M2-like (M2-TAMs), myeloid-derived suppressor (MDSCs), regulatory (Tregs) activated. These changes make it difficult produce effects affect efficacy of chemo-immunotherapy. mechanisms apoptosis inhibition, DNA damage response (DDR), epithelial-mesenchymal transition (EMT) promote growth, metastasis, Despite challenges posed by TME in treatment AOC, unique biological advantages nanoparticles (NPs) possible regulate NPs stimulate responses M1-TAMs, DCs, while reducing infiltration suppressive M2-TAMs Tregs, thereby regulating AOC addition, cells, inhibiting homologous recombination (HR) repair, reversing EMT, achieving effect summary, application provides some new venues for clinical AOC.

Язык: Английский

A new strategy for the treatment of advanced ovarian cancer: utilizing nanotechnology to regulate the tumor microenvironment DOI Creative Commons

Zixuan Xiong,

Yi‐Chun Huang,

Shulong Cao

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Фев. 12, 2025

Advanced ovarian cancer (AOC) is prone to recurrence, which can be attributed drug resistance. Drug resistance may related the tumor microenvironment (TME), including immune and non-immune TME. In TME, effector cells such as dendritic (DCs), M1-like tumor-associated macrophages (M1-TAMs), T are inhibited. contrast, immunosuppressive M2-like (M2-TAMs), myeloid-derived suppressor (MDSCs), regulatory (Tregs) activated. These changes make it difficult produce effects affect efficacy of chemo-immunotherapy. mechanisms apoptosis inhibition, DNA damage response (DDR), epithelial-mesenchymal transition (EMT) promote growth, metastasis, Despite challenges posed by TME in treatment AOC, unique biological advantages nanoparticles (NPs) possible regulate NPs stimulate responses M1-TAMs, DCs, while reducing infiltration suppressive M2-TAMs Tregs, thereby regulating AOC addition, cells, inhibiting homologous recombination (HR) repair, reversing EMT, achieving effect summary, application provides some new venues for clinical AOC.

Язык: Английский

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