Migrasome-Related Genes as Potential Prognosis and Immunotherapy Response Predictors for Colorectal Cancer
Biomedicines,
Год журнала:
2025,
Номер
13(4), С. 799 - 799
Опубликована: Март 26, 2025
Background:
Studies
highlight
the
role
of
migrasomes
as
mediators
intercellular
communication
and
signaling,
critical
in
influencing
tumorigenesis
progression.
Yet
migrasome-related
genes
their
potential
colorectal
cancer
prognosis
remain
unexplored.
Methods:
Differentially
expressed
gene
set
A
(DEG
A)
was
identified
TCGA-CRC
dataset,
Weighted
Gene
Co-expression
Network
Analysis
(WGCNA)
performed
to
identify
most
important
modules
associated
with
(MRG)
scores.
Single-cell
RNA-seq
dataset
GSE231559
DEG
B
determined.
Candidate
were
filtered
by
intersecting
DGE
A,
key
module
genes,
B.
Prognostic
subsequently
screened
through
regression
analysis,
a
risk
model
developed.
Patients
CRC
TCGA
cohort
stratified
into
high-
low-risk
groups
based
on
optimal
cutoff
score.
Immunotherapy
response-related
analyses
then
performed.
Finally,
cell-to-cell
analysis
carried
out
for
cells
prognostic
expression
annotated
cells.
Results:
The
six
candidate
overlap
5158
1960
146
Further
screening
led
selection
T1MP1,
CXCL8,
MGP
biomarkers.
Immune-related
indicated
that
high-risk
group
exhibited
better
response
immunotherapy.
Notably,
showed
elevated
levels
monocytes
tissue
stem
cells,
thereby
designating
them
cell
types.
Conclusions:
We
conducted
bioinformatic
significant
involvement
immunotherapy
response.
Our
research
provides
novel
insights
biology.
Язык: Английский
Migrasomes as intercellular messengers: potential in the pathological mechanism, diagnosis and treatment of clinical diseases
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 20, 2025
Migrasomes
are
newly
identified
organelles
that
were
first
discovered
in
2015.
Since
then,
their
biological
structure,
formation
process,
and
physiological
functions
have
been
gradually
elucidated.
Research
recent
years
has
expanded
our
understanding
of
these
aspects,
highlighting
significance
various
pathological
processes.
found
to
play
crucial
roles
normal
functions,
including
embryonic
development,
vascular
homeostasis,
material
transport,
mitochondrial
quality
control.
Additionally,
emerging
evidence
suggests
involvement
diseases;
however,
clinical
research
on
remains
limited.
Current
studies
indicate
migrasomes
may
contribute
disease
pathogenesis
hold
potential
for
diagnostic
therapeutic
applications.
This
review
consolidates
existing
migrasomes,
focusing
role
mechanisms
use
medical
By
examining
structure
function,
this
aims
generate
insights
encourage
further
research,
ultimately
contributing
advancements
prevention
treatment.
Язык: Английский