Timed Formation and Aging of Complex Coacervates Using a Volatile Salt DOI
L. Yan, Weiwei Zheng, Emilie Muller

и другие.

Macromolecules, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Biomolecular condensates are liquid droplets formed by liquid–liquid phase separation and play a role in variety of cellular processes. In the past decade, there has been growing interest their study, often through use complex coacervates as models. Despite similar properties, limitation is inability to show time-dependent behavior, such aging, they typically structures thermodynamic equilibrium (or kinetically trapped). Here, we present simple protocol trigger delayed formation aging coacervates. We ammonium carbonate for this protocol, volatile salt that decreases ionic strength solution it decomposes. Using salt, were able program coacervate after delays ranging from hours days. This process can be repeated multiple times, decomposition leaves no waste products. The mechanical properties also change over time with showing steady increase viscosity reminiscent condensates. Since element causes temporal evolution not coacervates, does require any synthesis easily adapted

Язык: Английский

Timed Formation and Aging of Complex Coacervates Using a Volatile Salt DOI
L. Yan, Weiwei Zheng, Emilie Muller

и другие.

Macromolecules, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Biomolecular condensates are liquid droplets formed by liquid–liquid phase separation and play a role in variety of cellular processes. In the past decade, there has been growing interest their study, often through use complex coacervates as models. Despite similar properties, limitation is inability to show time-dependent behavior, such aging, they typically structures thermodynamic equilibrium (or kinetically trapped). Here, we present simple protocol trigger delayed formation aging coacervates. We ammonium carbonate for this protocol, volatile salt that decreases ionic strength solution it decomposes. Using salt, were able program coacervate after delays ranging from hours days. This process can be repeated multiple times, decomposition leaves no waste products. The mechanical properties also change over time with showing steady increase viscosity reminiscent condensates. Since element causes temporal evolution not coacervates, does require any synthesis easily adapted

Язык: Английский

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