Interkingdom signaling between gastrointestinal hormones and the gut microbiome

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 24, 2025

The interplay between the gut microbiota and gastrointestinal hormones plays a pivotal role in health of host development diseases. As vital component intestinal microecosystem, influences synthesis release many through mechanisms such as modulating environment, producing metabolites, impacting mucosal barriers, generating immune inflammatory responses, releasing neurotransmitters. Conversely, exert feedback regulation on by nutrient absorption utilization, bacterial biological behavior composition. distributions are anatomically intertwined, close interactions crucial for maintaining homeostasis. Interventions leveraging have been employed clinical management metabolic diseases bowel diseases, bariatric surgery fecal transplantation, offering promising targets treatment dysbiosis-related

Язык: Английский

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Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating Lactobacillus rhamnosus GG

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With growing knowledge about gut–bone axis, therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. AlthoughLactobacillus rhamnosus GG (LGG) widely reported positively regulate metabolism by restoring dysbiotic microbiome, oral administration sensitivity gastric fluid low bioavailability. Other studies also demonstrated that bisphosphonates ameliorate directly metabolism, especially inhibiting osteoclast activity. However, side effects caused bisphosphonate treatment still represent a significant problem. In this study, we assembled alendronate, clinically used bisphosphonate, DSPE-phospholipid nanoencapsulation LGG (ADB), protect from acidic environment of stomach, while simultaneously reducing gastrointestinal alendronate. We further investigated potential these nanoencapsulated bacteria ADB repair osteoporotic deterioration, their ability in vivo, which strongly intrinsic environment. Compared same dosage alendronate alone, regulated was significantly revised ovariectomized mice models.

Язык: Английский

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In vivo monitoring of endogenous hydrogen sulfide and evaluation of natural protectants in liver injury mice using a highly selective bioluminescent probe

Biosensors and Bioelectronics, Год журнала: 2025, Номер 278, С. 117343 - 117343

Опубликована: Март 5, 2025

Язык: Английский

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Huang Qin decoction supplemented diet attenuates Aeromonas hydrophila-induced intestinal inflammation via the Delta/notch pathway in Eriocheir sinensis

Aquaculture, Год журнала: 2025, Номер unknown, С. 742427 - 742427

Опубликована: Март 1, 2025

Язык: Английский

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Protective Effects of a Polyherbal Mixture on Intestinal Injury via the NF-κB Signaling Pathway and Gut Microbiota Modulation in Hyperuricemic Mice

Foods, Год журнала: 2025, Номер 14(7), С. 1118 - 1118

Опубликована: Март 24, 2025

This study investigated the protective effects of a polyherbal tea (PHT) on intestinal injury in hyperuricemia (HUA) mice and underlying mechanisms. PHT was orally administered to for 49 days, while potassium oxonate hypoxanthine were 7 days after administration continued 42 cause HUA. Treatment with significantly reduced serum uric acid blood urea nitrogen levels HUA mice. It also inhibited liver xanthine oxidase activity promoted excretion through upregulation transporters GLUT9 ABCG2. Intestinal barrier integrity reinforced, as evidenced by restoration villous structure, reduction edema, tight junction proteins (occludin, ZO-1) mucin (MUC2). Moreover, suppressed LPS NF-κB pathway, leading TNF-α IL-6 gut. Gut microbiota analysis revealed reversed dysbiosis, enriching beneficial bacteria like Duncaniella sp. Heminiphilus faecis. By UPLC-MS analysis, 154 compounds persisted gut, suggesting that these are likely modulate both function gut microbiota. These findings suggest this may have potential functional food prevention hyperuricemia.

Язык: Английский

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Distal small bowel resection with the preservation of terminal ileum suppresses hepatic gluconeogenesis via the Prevotellaceae_NK3B31_group-mediated 7-KLCA-FXR axis

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Previous studies have indicated that distal small bowel resection with preservation of the terminal ileum (DBRPI) significantly lowers blood glucose levels and improves tolerance, presumably through mechanisms involving increased bile acid glucagon-like peptide-1 secretion. In this study, we observed time-dependent increases in tolerance weight loss following DBRPI, accompanied by certain beneficial alterations lipid metabolism. At 6 weeks postsurgery, noted a significant downregulation key gluconeogenic enzyme-encoding genes glucose-6-phosphatase phosphoenolpyruvate carboxykinase 1 addition to upregulation farnesoid X receptor ileum. Additionally, DBRPI abundance Prevotellaceae_NK3B31_group elevated 7-ketolithocholic (7-KLCA) while reducing Desulfovibrio_fairfieldensis α-muricholic levels. Further correlation analysis revealed positive association between altered metabolism indicators. Our findings suggest can increase obese rats inhibiting hepatic gluconeogenesis, potentially activation Prevotellaceae_NK3B31_group-induced 7-KLCA-FXR signaling pathway.

Язык: Английский

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The Role of Bacteria-Derived Hydrogen Sulfide in Multiple Axes of Disease

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(7), С. 3340 - 3340

Опубликована: Апрель 3, 2025

In this review article, we discuss and explore the role of bacteria-derived hydrogen sulfide. Hydrogen sulfide is a signaling molecule produced endogenously that plays an important in health disease. It also by gut microbiome. setting microbial disturbances leading to disruption intestinal homeostasis (dysbiosis), concentration available can vary pathologic sequelae. The brain-gut axis original studied paradigm microbiome host interaction. recent years, our understanding interaction has expanded greatly include specific pathways have branched into their own axes. These axes share principal concept microbiota changes, permeability, inflammatory response, some which are modulated (H2S). review, will multiple including gut-immune, gut-heart, gut-endocrine We evaluate H2S modulation barrier, mucosal healing inflammation tumor genesis. alpha-synuclein aggregation ischemic injury. Finally, metabolic syndrome as int pertains hypertension, atherosclerosis glucose-like peptide-1 activity. Majority studies focus on endogenous production; examine lesser-known source progression diseases it relates these

Язык: Английский

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β-Glucan Extracted from Pichia kudriavzevii DPUL-51–6Y, Kluyveromyces marxianus DPUL-F15, and Saccharomyces cerevisiae DPUL-C6 Shows Ameliorating Effects on DSS-Induced Ulcerative Colitis on BALB/c Mice

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

β-Glucans derived from yeast are recognized as beneficial food additives. This study evaluated crude β-glucan extracts Pichia kudriavzevii DPUL-51-6Y, Kluyveromyces marxianus DPUL-F15, and Saccharomyces cerevisiae DPUL-C6 strains for their anticolitis potential. Chemical analysis revealed that was the primary component (71.88-78.47% purity). Notably, S. extract displayed superior thermal stability hydration capacity. In RAW264.7 macrophages, pretreatment at 100 μg/mL significantly reduced LPS-induced nitric oxide production pro-inflammatory cytokines by suppressing NF-κB signaling through reduction of p65 IκB-α while simultaneously activating Nrf2 AHR pathways. DSS-induced colitis BALB/c mice, oral administration β-glucans alleviated intestinal damage enhancing tight junction protein expression restoring gut microbiota composition, characterized an increased abundance Lactobacillus Prevotella. These effects were correlated with microbial metabolites, including indole-3-lactic acid, indole-3-β-acrylic tryptophol, short-chain fatty acids (acetic, propionic, butyric acids). Mechanistically, mitigated dual activation Nrf2/AHR pathways inhibition NF-κB. suggests yeast-derived plays a significant role in mitigating inflammatory response may alleviate ulcerative reshaping community metabolite profiles host tract.

Язык: Английский

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Ageing, Proteostasis, and the Gut: Insights into Neurological Health and Disease

Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102504 - 102504

Опубликована: Сен. 1, 2024

Язык: Английский

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Dynamic Hyaluronic Acid Hydrogels for Comprehensively Regulating Inflammation, Angiogenesis, and Metabolism to Effectively Proheal Diabetic Wounds

ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(51), С. 70256 - 70273

Опубликована: Дек. 13, 2024

Despite the great progress of various multifunctional wound dressings, it is challenging to simultaneously achieve complete healing and functional remodeling for diabetic foot ulcers refractory chronic wounds. Aiming comprehensively regulate inflammation, angiogenesis, metabolism processes, herein, a novel kind dynamic hyaluronic acid (HA) hydrogel was designed by combining boronate coordination chemistry. Besides having injectability, self-healing, detachment properties, HA hydrogels presented wound-responsive degradation controllable H2S release. They could efficiently polarize M1-to-M2 polarization inflammatory cytokine secretion multiple inflammation-related mRNA expressions through cooperative actions reactive oxygen species elimination + release Zn2+ regulation, thus driving inflammation into proliferation stages. Moreover, screened lead HTZS angiogenesis-related signaling pathways processes promote neovascularization mature vessel formation, re-epithelization, high-level collagen-I deposition, dense hair follicle regeneration, achieving in Importantly, this work opens new avenue design biopolymer high-performance dressing decipher key role orchestrated regulations inflammation–angiogenesis–metabolism on

Язык: Английский

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