Food intake enhances hippocampal sharp wave-ripples

Опубликована: Янв. 27, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body's state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding-when need increases, if so, feeding-dependent modulation communicated other regions regulation-remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Язык: Английский

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Feeding the hippocampus … with specific nutrients

Nature Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Язык: Английский

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Hunger Games: A Modern Battle Between Stress and Appetite

Journal of Neurochemistry, Год журнала: 2025, Номер 169(2)

Опубликована: Фев. 1, 2025

ABSTRACT Stress, an evolutionarily adaptive mechanism, has become a pervasive challenge in modern life, significantly impacting feeding‐relevant circuits that play role the development and pathogenesis of eating disorders (EDs). Stress activates hypothalamic–pituitary–adrenal (HPA) axis, disrupts specific neural circuits, dysregulates key brain regions, including hypothalamus, hippocampus, lateral septum. These particular structures are interconnected integrating stress feeding signals, modulating hunger, satiety, cognition, emotional coping behaviors. Here we discuss interplay between genetic predispositions environmental factors may exacerbate ED vulnerability. We also highlight most commonly used animal models to study mechanisms driving EDs recent rodent studies emphasize discovery novel cellular molecular signals within hippocampus–lateral septum–hypothalamus axis. In this review, gut microbiome, emerging area research field unanswered questions persist hinder scientific progress, such as why some individuals remain resilient while others at high risk for EDs. finally need future delineating impact stressors on clarifying relevance functionality hippocampal–septal–hypothalamic connectivity, investigating neuropeptides CRH, oxytocin, GLP‐1 human pathogenesis. Emerging tools like single‐cell sequencing advanced imaging could uncover circuit‐level changes areas relevant patients. Ultimately, by basic clinical research, science offers promising avenues developing personalized, mechanism‐based treatments targeting maladaptive behavior patients suffering from image

Язык: Английский

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Food intake enhances hippocampal sharp wave-ripples

Опубликована: Апрель 3, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding– when need increases, if so, feeding-dependent modulation communicated other regions regulation, remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Язык: Английский

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Food intake enhances hippocampal sharp wave-ripples

eLife, Год журнала: 2025, Номер 14

Опубликована: Апрель 14, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding—when need increases, if so, feeding-dependent modulation communicated other regions regulation—remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Язык: Английский

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Vagal Sensory Gut–Brain Pathways That Control Eating—Satiety and Beyond

Comprehensive physiology, Год журнала: 2025, Номер 15(2)

Опубликована: Апрель 1, 2025

ABSTRACT The vagus nerve is the body's primary sensory conduit from gut to brain, traditionally viewed as a passive relay for satiety signals. However, emerging evidence reveals far more complex system—one that actively encodes diverse aspects of meal‐related information, mechanical stretch nutrient content, metabolic state, and even microbial metabolites. This review challenges view vagal afferent neurons (VANs) simple meal‐termination sensors highlights their specialized subpopulations, modalities, downstream brain circuits, which shape feeding behavior, metabolism, cognition. We integrate recent advances single‐cell transcriptomics, neural circuit mapping, functional imaging examine how VANs contribute gut–brain communication beyond satiety, including roles in food reward memory formation. By synthesizing latest research highlighting directions field, this provides comprehensive update on pathways role integrators meal information.

Язык: Английский

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