Andrias davidianus Derived Glycosaminoglycans Direct Diabetic Wound Repair by Reprogramming Reparative Macrophage Glucolipid Metabolism

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Abstract Harnessing cross‐species regenerative cues to direct human potential is increasingly recognized as an excellent strategy in medicine, particularly for addressing the challenges of impaired wound healing aging populations. The skin mucus Andrias davidianus plays a critical role self‐protection and tissue repair, yet fundamental factors mechanisms involved remain elusive. Here, this work presents evidence that glycosaminoglycans (GAGs) derived from secretion (SAGs) serve potent mediators angiogenesis inflammatory remodeling, facilitating efficient diabetic wounds. Mechanistic studies reveal SAGs promote macrophage polarization toward anti‐inflammatory pro‐regenerative phenotype (CD206 + /Arg1 ) via glucolipid metabolic reprogramming. This process suppresses excessive inflammation enhances expression VEGF IL‐10 create facilitative microenvironment regeneration. Additionally, develops SAGs‐GelMA composite microspheres address multiple stages healing, including rapid hemostasis, exudate control, activation endogenous processes. engineered approach significantly improves scarless wounds by recruitment reparative macrophages. findings offer new insights into highlight therapeutic application repair.

Язык: Английский

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Drug safety in healthy aging

npj Aging, Год журнала: 2025, Номер 11(1)

Опубликована: Апрель 12, 2025

Язык: Английский

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What are blue zones? An argument in favor of its definition based on the most successful model of biological aging

Aging Medicine, Год журнала: 2024, Номер 7(4), С. 446 - 448

Опубликована: Авг. 1, 2024

Язык: Английский

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Fostering Healthy Longevity Through Regenerative and Precision Medicine: Biodiversity’s Vital Role and Equitable Benefit Sharing

Опубликована: Янв. 1, 2024

Язык: Английский

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