Comparative analysis of human and mouse ovaries across age

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Abstract Mouse is a tractable model for human ovarian biology, however its utility limited by incomplete understanding of how transcription and signaling differ interspecifically with age. We compared ovaries between species using 3D-imaging, single-cell transcriptomics, functional studies. In mice, we mapped declining follicle numbers oocyte competence during aging; in ovaries, identified cortical pockets density changes. Oocytes had species-specific gene expression patterns growth that converged toward maturity. Age-related transcriptional changes were greater oocytes than granulosa cells across species, although mature change more humans. sympathetic nerves glia; nerve increased aged and, when ablated perturbed folliculogenesis. This comparative atlas defines shared hallmarks biology.

Язык: Английский

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Ursonic Acid Ameliorates H2O2-Induced Oxidative Damage in PC12 Cells and Prolonged the Lifespan in C. elegans by Activating MAPKs/Nrf2/HO-1 Signaling Pathway

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Язык: Английский

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Editorial: Genetics and epigenetics in ovarian aging

Frontiers in Endocrinology, Год журнала: 2025, Номер 16

Опубликована: Фев. 11, 2025

begins in a mid-30s, with menopause usually occurring between the 24 ages of 48 and depletion oocyte stock (ovarian aging) being an inevitable process 25 during woman's lifetime, ultimately influencing lifespan health outcomes. Ovarian aging is 26 multidimensional characterized by progressive decline follicle number 27 quality that accelerates around 37 years age, leading to increased infertility congenital 28 disabilities offspring 1

Язык: Английский

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Hallmarks of ovarian aging

Trends in Endocrinology and Metabolism, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Comprehensive analysis of lipid metabolic signatures identified CEBPD promotes breast cancer cell proliferation

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 24, 2025

Breast cancer (BRCA) remains the leading cause of cancer-related mortality worldwide, with lipid metabolism emerging as a critical factor in tumor progression that influences cell proliferation, migration, and immune response. Insights into signatures associated genes may offer new prognostic therapeutic avenues. In this study, we leveraged scRNA-seq bulk transcriptome data to assess expression patterns significance metabolism-related BRCA. Through single-cell transcriptomic analysis primary BRCA samples, identified specific set signature constructed risk model based on these signatures. This enables patient stratification by scores, supporting an integrated metabolism, landscape, clinical outcomes. Importantly, CEBPD, ABCA1, CYP27A1 independent linked functional assays revealing inhibitory role for CEBPD proliferation. Our findings underscore influence adipocytes propose potential target intervention. study provides foundation further exploration metabolism-based strategies enhance

Язык: Английский

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The network structural entropy for single-cell RNA sequencing data during skin aging

Briefings in Bioinformatics, Год журнала: 2024, Номер 26(1)

Опубликована: Ноя. 22, 2024

Abstract Aging is a complex and heterogeneous biological process at cellular, tissue, individual levels. Despite extensive effort in scientific research, comprehensive understanding of aging mechanisms remains lacking. This study analyzed aging-related gene networks, using single-cell RNA sequencing data from >15 000 cells. We constructed correlation network, integrating expressions into the weights network edges, ranked importance random walk model to generate matrix. unsupervised method improved clustering performance cell types. To further quantify complexity networks during aging, we introduced structural entropy. The findings our reveal that overall entropy increases aged cells compared young However, changes varied greatly within different subtypes. Specifically, among various types may increase, remain unchanged, or decrease. wide range be closely related their functions, highlighting cellular heterogeneity potential key reconfigurations. Analyzing provides insights molecular behind aging. offers new evidence theoretical support for functions

Язык: Английский

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The year in review: 2024 signals a new era in reproductive medicine

Journal of Assisted Reproduction and Genetics, Год журнала: 2024, Номер unknown

Опубликована: Дек. 24, 2024

Язык: Английский

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