Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Апрель 25, 2025
Язык: Английский
Nature, Год журнала: 2025, Номер unknown
Опубликована: Фев. 3, 2025
Язык: Английский
Процитировано
0
Journal of the American Nutrition Association, Год журнала: 2025, Номер unknown, С. 1 - 8
Опубликована: Март 10, 2025
Background As the global population ages, extending not only life expectancy (LE) but also healthy (HALE) has become a critical public health objective. Dietary choices, especially intake of various fatty acids, may play role in achieving good health.
Язык: Английский
Процитировано
0
Molecular Neurodegeneration, Год журнала: 2025, Номер 20(1)
Опубликована: Март 21, 2025
Язык: Английский
Процитировано
0
iMeta, Год журнала: 2025, Номер unknown
Опубликована: Апрель 12, 2025
Abstract Aging‐related decline and adaptation are complex, multifaceted processes that affect various tissues increase risk of chronic diseases. To characterize key changes in cross‐tissue aging, we performed comprehensive proteomic metabolomic analyses across 21 solid plasma samples, alongside shotgun metagenomic profiling fecal microbial communities young aged mice. Our findings revealed widespread aging‐rewired inflammation, characterized by complement system activation universal immunoglobulins accumulation multiple tissues. This inflammatory remodeling significantly enhanced vulnerability to aging‐related tissue injury. Moreover, identified organ‐specific organ‐enriched proteins with high functional specificity. Among these, were closely linked disorders arising from lipid metabolism dysfunction. Analysis multi‐tissue profiles aging disrupted inter‐tissue metabolic coupling, activities polyunsaturated fatty acids metabolism, gut microbiota homeostasis. Aged mice exhibited a marked decrease Escherichia an Helicobacter , strongly correlating alterations omega‐3 omega‐6 acid abundances. Through multi‐omics integration, molecular hubs driving organismal responses aging. Collectively, our study uncovers extensive aging‐associated tissues, emphasizing the interplay between systemic inflammation dysbiosis‐driven remodeling. These provide deeper insights into development healthy perspective.
Язык: Английский
Процитировано
0
Biology, Год журнала: 2025, Номер 14(5), С. 463 - 463
Опубликована: Апрель 24, 2025
Obesity is a significant global health issue, profoundly affecting metabolic and cardiovascular other related chronic conditions. In Chile, the prevalence of obesity among highest within Organisation for Economic Cooperation Development (OECD) countries, highlighting critical public challenge. This narrative review examines current evidence on independent potential synergistic roles omega-3 fatty acids exercise in managing obesity-related dysfunction. Omega-3 acids, particularly eicosapentaenoic acid (EPA), have been shown to lower triglyceride levels, enhance lipid metabolism, modulate inflammation via pathways involving peroxisome proliferator-activated receptors (PPARs) sterol regulatory element-binding protein-1c (SREBP-1c). Exercise interventions, such as moderate-intensity continuous training (MICT) high-intensity interval (HIIT), provide distinct yet complementary benefits. Specifically, MICT improves body fat distribution mitochondrial efficiency, whereas HIIT has notable effects adaptability insulin signaling. Additionally, emerging points toward role kinin-kallikrein system, kallikrein 7 (KLK7), obesity-associated resistance. Despite these promising findings, several knowledge gaps persist regarding optimal dosing, intervention timing, population-specific effects, exact mechanisms behind interactions between supplementation structured exercise. emphasizes importance conducting further research, controlled clinical trials, clarify combined interventions’ effectiveness establish targeted therapeutic strategies tailored individual profiles.
Язык: Английский
Процитировано
0
Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)
Опубликована: Апрель 25, 2025
Язык: Английский
Процитировано
0