Mesenchymal stem cells and their derivatives as potential longevity-promoting tools DOI Creative Commons

Ekaterina Rudnitsky,

Alex Braiman,

Marina Wolfson

и другие.

Biogerontology, Год журнала: 2025, Номер 26(3)

Опубликована: Апрель 21, 2025

Abstract Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity treat age-related diseases. MSCs have low immunogenicity tumorigenicity, their efficacy is relatively independent of the donor age in humans (but not rodents). Systemic administration cell/blood-derived EVs modified omic profiles various organs aged rodents towards young ones. The application appears be even more beneficial than MSCs. Remarkably, over 70% microRNAs, which are over-presented ESC-derived EVs, were found target longevity-associated genes. Along with MSCs, other types reported display health- lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation possess number unique features, could particularly relevant for promoting healthspan. rejuvenation potential warrants further investigation both animal models clinical trials, using aging clocks biological determination as one endpoints.

Язык: Английский

Mesenchymal stem cells and their derivatives as potential longevity-promoting tools DOI Creative Commons

Ekaterina Rudnitsky,

Alex Braiman,

Marina Wolfson

и другие.

Biogerontology, Год журнала: 2025, Номер 26(3)

Опубликована: Апрель 21, 2025

Abstract Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity treat age-related diseases. MSCs have low immunogenicity tumorigenicity, their efficacy is relatively independent of the donor age in humans (but not rodents). Systemic administration cell/blood-derived EVs modified omic profiles various organs aged rodents towards young ones. The application appears be even more beneficial than MSCs. Remarkably, over 70% microRNAs, which are over-presented ESC-derived EVs, were found target longevity-associated genes. Along with MSCs, other types reported display health- lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation possess number unique features, could particularly relevant for promoting healthspan. rejuvenation potential warrants further investigation both animal models clinical trials, using aging clocks biological determination as one endpoints.

Язык: Английский

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