Multimodal associations between posterior hippocampus glutamate metabolism, visual cortex connectivity, and intrusive trauma reexperiencing symptoms

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Objective Hippocampal dysfunction is implicated in posttraumatic stress disorder (PTSD), particularly intrusive reexperiencing symptoms, and may be mediated by glutamatergic excitotoxicity. Markers of glutamate (higher to N-acetyl aspartate levels; Glu/NAA) the hippocampus (HPC) have been linked symptoms. However, HPC demonstrates heterogeneity along its anterior-posterior axis, with different functional connectivity patterns PTSD symptom associations, motivating investigations into metabolism anterior posterior subregions (a/pHPC). Methods 121 symptomatic trauma-exposed adults (93 female) current trauma symptoms completed magnetic resonance spectroscopy resting-state imaging examine regional specificity Glu/NAA associations reexperiencing, link a/pHPC connectivity. were assessed Clinician-Administered Scale for DSM-5. Results Reexperiencing severity was associated greater pHPC, but not aHPC. pHPC further stronger between visual cortex (VC), which turn correlated more severe This strengthened pHPC-VC explained shared variance severity, suggesting dysregulated contribute through VC. Conclusions These findings replicate prior work linking provide novel evidence this association specific multimodal investigation supports translational models trauma-related disorders highlights new targets pharmacological neuromodulatory interventions.

Язык: Английский

Neuroscience-based relational art therapy and deep brain reorienting in the treatment of dissociative identity disorder

Frontiers in Psychology, Год журнала: 2025, Номер 16

Опубликована: Фев. 28, 2025

Art therapy (AT) has been proposed as a treatment for post-traumatic conditions, potentially by providing somatic sensory input that can (i) enhance the client’s sense of self and embodiment, (ii) modulate arousal, (iii) aid in rethinking reframing traumatic memories. However, evidence supporting AT dissociative disorders remains limited. The theoretical basis efficacy is discussed relation to findings regarding traumatized person’s brain mindset, well its altered functional network connectivity. It crucial consider specific alterations networks associated with trauma, particularly those occurring deep regions, which include midbrain, brainstem, cerebellum. hypothesis suggests early or severe trauma impair brain’s higher regulatory functions, explained cascade theory. This theory explains how diverse activation patterns within midbrain’s periaqueductal gray (PAG) midbrain influence limbic system cortices, thereby modulating states being behavior. Phase-specific, resource-oriented, long-term complexly individuals benefit from novel insights neuroimaging studies inform therapeutic methods. illustrated clinical vignette client diagnosed identity disorder (DID), where reorienting (DBR) was combined relational AT. component hypothesized have facilitated grounding present moment enhanced access her neurophenomenological self. Moreover, changes may occurred at implicit non-verbal levels. DBR believed helped remain previously avoided unbearable internal experience. To validate these assumptions, second author conducted semi-structured interview focused on experiences psychotherapy , including effect when introduced after were articulated through thematic analysis interview, yielded following themes: Loneliness, getting help moving towards togetherness . Further research development methods neuroplasticity necessary highly clients change heal are recommended.

Язык: Английский

Toward Neuroscientific Understanding in Posttraumatic Growth: Scoping Review Identifying Electrophysiological Neurofeedback Training Targets for Brain-based Research

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 167, С. 105926 - 105926

Опубликована: Окт. 18, 2024

Improved neural understanding of posttraumatic growth (PTG) is required for effective trauma care. PTG the advantageous psychological change some individuals derive from their struggle to overcome trauma. This comprehensive review critically examined limited research, identify electrophysiological training targets future research examining neurofeedback enhance PTG, and provides novel insights into emerging theory PTG. PRISMA-ScR (Preferred Reporting Items Systematic reviews Meta-Analyses extension Scoping Reviews) informed process. Findings studies N=8 (participants N=765) revealed was correlated with left-lateralised alpha frequency power patterns. Specifically, associated lower left frontal power, higher central parietal power. Differences between may different components PTG-related circuitry, or represent variations in sub-factor strength, mechanistic differences studies, potential confounding presence stress disorder (PTSD). While has been PTSD existing literature, PTSD. Therefore, upregulation delivered over sensorimotor cortex brain, around EEG electrode C3, presented most promising target.

Язык: Английский