Photothermal-driven soft actuator capable of alternative control based on coupled-plasmonic effect

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155057 - 155057

Опубликована: Авг. 23, 2024

Recent advancements in small-scale soft actuators have showcased their ability to respond various stimuli, making them ideal for biomedical engineering and robotics.Light-responsive constructed from photothermal materials such as carbon-based received great attention remote wireless control ability.However, conventional typically exhibit uniform responses different light wavelengths, limiting the complexity of control.To address this limitation, study develops lightdriven utilizing gold nanorods (Au NRs) enhance selective photo-responsiveness. Au NRs are incorporated given superior convert energy into localized heat through surface plasmon resonances, with efficiency varying based on size wavelength incident light.By adjusting specifications optical field, tunable actuation can be achieved.Experimental calibration confirms that actuator exhibits differential performance across enabling more precise over its behavior.Demonstrations application devices highlight actuator's versatility flexible robotics, showcasing potential advanced applications.This innovation represents a considerable step towards achieving adaptable functional robotic systems, paving way future developments area.

Язык: Английский

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Cancer Cell Removing Using a Reinforcement Learning Agent

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

Abstract Cancer cell is a deadly problem which the main cause of global death. Unfortunately, conventional therapies like chemo/radio therapy are not viable ways to remove all cancer cells. Although Robotic achievements have been increased in therapy, these devices do decision-making ability grasp their environment biologists. In this paper, removing method based on Artificial Intelligence techniques introduced. The proposed idea adopts combination object detection and reinforcement model order detect cells take some actions them. To implement idea, YOLOv9 trained image dataset segment create set point for RL then next step, Soft Actor Critic (SAC) considered as desired appropriate reach target. experimental result shows that can be adopted different robots micro/wireless soft boost performance terms ability.

Язык: Английский

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Wireless Hybrid-Actuated Soft Miniature Robot for Biomedical Applications

Actuators, Год журнала: 2024, Номер 13(9), С. 341 - 341

Опубликована: Сен. 5, 2024

Wireless soft miniature robots have been studied for biomedical applications. However, the wireless developed so far are mainly composed of synthetic polymers that do not guarantee biocompatibility and biodegradability. Additionally, current limitations in demonstrating mobility narrow spaces, such as blood vessels within body, by using their flexible body. This study proposes a hybrid-actuated robot The proposed consists biodegradable chitosan magnetic nanoparticles (MNPs) is fabricated into an eight-arm shape laser micromachining. can implement hydrogel swelling magnetic-actuated morphing difference MNP density field responsiveness respectively. Furthermore, be guided external fields. As feasibility tests, demonstrated on-demand pick-and-place motion, grasping bead, moving it to desired location, releasing it. in-channel test, body passed through tube smaller size than itself magnetically actuated morphing. These results indicate with controllable change precise magnetic-driven minimally invasive surgical disease diagnosis treatment.

Язык: Английский

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Heterogeneous multiple soft millirobots in three-dimensional lumens

Science Advances, Год журнала: 2024, Номер 10(45)

Опубликована: Ноя. 6, 2024

Miniature soft robots offer opportunities for safe and physically adaptive medical interventions in hard-to-reach regions. Deploying multiple could further enhance the efficacy multifunctionality of these operations. However, multirobot deployment physiologically relevant three-dimensional (3D) tubular structures is limited by lack effective mechanisms independent control miniature magnetic robots. This work presents a framework leveraging shape-adaptive robotic design heterogeneous resistance from robot-lumen interactions to enable control. We first compute influence actuation regions quantify robot movement. Subsequently, path planning algorithm generates trajectory permanent magnet navigation 3D lumens. Last, are controlled individually multilayer lumen networks under imaging. Demonstrations multilocation cargo delivery flow diversion manifest their potential biomedical functions. offers solution benefiting applications across different devices complex environments.

Язык: Английский

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Magnetic soft microrobots for erectile dysfunction therapy

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(49)

Опубликована: Ноя. 18, 2024

Erectile dysfunction (ED) is a major threat to male fertility and quality of life, mesenchymal stromal cells (MSCs) are promising therapeutic option. However, outcomes compromised by low MSC retention survival rates in corpus cavernosum tissue. Here, we developed an innovative magnetic soft microrobot comprising ultrasoft hydrogel microsphere embedded with nanoparticle chain for delivery. This design also features phenylboronic acid groups scavenging reactive oxygen species (ROS). With Young’s modulus less than 1 kPa, the adapts its shape within narrow blood vessels, ensuring uniform distribution MSCs cavernosum. Our findings showed that compared traditional injections, delivery (MSC-Rob) significantly enhanced survival. In both rat beagle ED models, MSC-Rob treatment accelerated repair tissue restored erectile function. Single-cell RNA sequencing (scRNA-seq) revealed facilitates nerve vessel regeneration increasing presence regenerative macrophages. Overall, our not only advances clinical application therapy but broadens scope microrobots other cell therapies.

Язык: Английский

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