Noncoding RNAs evolutionarily extend animal lifespan

Global Medical Genetics, Год журнала: 2025, Номер 12(2), С. 100034 - 100034

Опубликована: Фев. 25, 2025

The mechanisms underlying the evolution of lifespan across organisms remain mysterious. This study computes multiple large datasets and reveals that noncoding RNAs (ncRNAs), rather than proteins, drive animal evolution. Species in kingdom evolutionarily increase their ncRNA length genomes, coinciding with trimming mitochondrial genome length. leads to a low energy consumption longevity. Notably, as species evolve extend lifespans, they tend acquire long-lived motifs while simultaneously losing short-lived ones, contrast conservative patterns observed protein These longevity-associated motifs, such GGTGCG, are particularly active crucial tissues including endometrium, ovaries, testes, cerebral cortex. ovary endometrium carry more activating ncRNAs testis, offering insight into why women generally outlive men. Taken together, two most important traits organisms: longevity reproduction, execute many fundamental functions those conventionally thought. discovery provides foundation for combating aging.

Язык: Английский

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LncRNAs Ride the Storm of Epigenetic Marks

Genes, Год журнала: 2025, Номер 16(3), С. 313 - 313

Опубликована: Март 6, 2025

Advancements in genome sequencing technologies have uncovered the multifaceted roles of long non-coding RNAs (lncRNAs) human cells. Recent discoveries identified lncRNAs as major players gene regulatory pathways, highlighting their pivotal role cell growth and development. Their dysregulation is implicated onset genetic disorders age-related diseases, including cancer. Specifically, they been found to orchestrate molecular mechanisms impacting epigenetics, DNA methylation hydroxymethylation, histone modifications, chromatin remodeling, thereby significantly influencing expression. This review provides an overview current knowledge on lncRNA-mediated epigenetic regulation expression, emphasizing biomedical implications development different types cancers diseases.

Язык: Английский

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Transposable Elements Contribute to the Regulation of Long Noncoding RNAs in Drosophila melanogaster

Insects, Год журнала: 2024, Номер 15(12), С. 950 - 950

Опубликована: Ноя. 30, 2024

Background: Transposable elements (TEs) and noncoding sequences are major components of the genome, yet their functional contributions to long RNAs (lncRNAs) not well understood. Although many lncRNAs originating from TEs (TE-lncRNAs) have been identified across various organisms, characteristics regulatory roles, particularly in insects, remain largely unexplored. This study integrated multi-omics data investigate TE-lncRNAs D. melanogaster, focusing on influence transposons different omics levels. Results: We 16,118 overlapping with lncRNA that constitute 2119 (40.4% all lncRNAs) using 256 public RNA-seq samples 15 lncRNA-seq Drosophila S2 cells treated heavy metals. Of these, 67.2% contain more than one TE. The LTR/Gypsy family was most common transposon insertion. Transposons preferred insert into promoters, transcription starting sites, intronic regions, especially chromosome ends. Compared lncRNAs, showed longer lengths, a lower conservation, levels but higher specificity expression. Multi-omics analysis revealed positive correlations between insertions chromatin openness at pre-transcriptional level. Notably, total 516 provided transcriptional factor binding sites through insertions. network key rewired by transposons, potentially recruiting other factors exert functions under metal stress. Additionally, 99 were associated m6A methylation modification 115 candidate small open reading frames Conclusions: Our demonstrated contribute regulation lncRNAs. only promote also facilitate post-transcriptional epigenetic regulation.

Язык: Английский

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Regulating translation in aging: from global to gene-specific mechanisms

EMBO Reports, Год журнала: 2024, Номер 25(12), С. 5265 - 5276

Опубликована: Ноя. 19, 2024

Язык: Английский

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