Effects of socioeconomic status on brain development, and how cognitive neuroscience may contribute to leveling the playing field

Frontiers in Human Neuroscience, Год журнала: 2010, Номер unknown

Опубликована: Янв. 1, 2010

THE STUDY OF SOCIOECONOMIC STATUS (SES) AND BRAIN FINDS ITSELF IN A CIRCUMSTANCE UNUSUAL FOR COGNITIVE NEUROSCIENCE: large numbers of questions with both practical and scientific importance exist, but they are currently under-researched ripe for investigation. This review aims to highlight these questions, outline their potential significance, suggest routes by which might be approached. Although remarkably few neural studies have been carried out so far, there exists a literature previous behavioural work. research provides an invaluable guide future neuroimaging work, also poses important challenge it: how can we ensure that the data contributes predictive or diagnostic power over above what derived from behaviour alone? We discuss some open mechanistic Cognitive Neuroscience may illuminate, spanning areas including language, numerical cognition, stress, memory, social influences on learning. These obvious societal bear directly set longstanding in basic science: environmental factors affect acquisition retention declarative nondeclarative skills? Perhaps best opportunity theoretical interests converge is study interventions. Many interventions aimed at improving cognitive development low SES children underway, almost all operating without either input from, by, community. Given longitudinal intervention very hard up, can, proper designs, ideal tests causal mechanisms, this area promises exciting opportunities research.

Язык: Английский

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Opioid receptors: From binding sites to visible molecules in vivo

Neuropharmacology, Год журнала: 2008, Номер 56, С. 205 - 212

Опубликована: Авг. 6, 2008

Язык: Английский

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Comprehensive qPCR profiling of gene expression in single neuronal cells

Nature Protocols, Год журнала: 2011, Номер 7(1), С. 118 - 127

Опубликована: Дек. 22, 2011

Язык: Английский

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Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

Neuropsychopharmacology, Год журнала: 2009, Номер 34(11), С. 2390 - 2403

Опубликована: Июль 1, 2009

Язык: Английский

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Vitamin D and Depression: Cellular and Regulatory Mechanisms

Pharmacological Reviews, Год журнала: 2017, Номер 69(2), С. 80 - 92

Опубликована: Фев. 15, 2017

Depression is caused by a change in neural activity resulting from an increase glutamate that drives excitatory neurons and may be responsible for the decline number of GABAergic inhibitory neurons. This imbalance between contribute to onset depression. At cellular level there concentration intracellular Ca²⁺ within driven entry through NMDA receptors (NMDARs) activation phosphoinositide signaling pathway generates inositol trisphosphate (InsP₃) releases internal stores. The importance these two pathways driving elevation supported fact depression can alleviated ketamine inhibits NMDARs scopolamine M1 drive InsP₃/Ca²⁺ pathway. not only contributes but it also explain why individuals with have strong likelihood developing Alzheimer's disease. enhanced levels stimulate formation Aβ initiate progression Alzheimer9s Just how vitamin D acts reduce unclear. phenotypic stability hypothesis argues reducing increased neuronal are action depends on its function maintain expression pumps buffers levels, which

Язык: Английский

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