The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Antiviral Research, Год журнала: 2020, Номер 178, С. 104787 - 104787

Опубликована: Апрель 3, 2020

Although several clinical trials are now underway to test possible therapies, the worldwide response COVID-19 outbreak has been largely limited monitoring/containment. We report here that Ivermectin, an FDA-approved anti-parasitic previously shown have broad-spectrum anti-viral activity in vitro, is inhibitor of causative virus (SARS-CoV-2), with a single addition Vero-hSLAM cells 2 h post infection SARS-CoV-2 able effect ~5000-fold reduction viral RNA at 48 h. Ivermectin therefore warrants further investigation for benefits humans.

Язык: Английский

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2): a global pandemic and treatment strategies

International Journal of Antimicrobial Agents, Год журнала: 2020, Номер 56(2), С. 106054 - 106054

Опубликована: Июнь 10, 2020

Язык: Английский

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Host and viral determinants of influenza A virus species specificity

Nature Reviews Microbiology, Год журнала: 2018, Номер 17(2), С. 67 - 81

Опубликована: Ноя. 28, 2018

Язык: Английский

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Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen

The Journal of Antibiotics, Год журнала: 2020, Номер 73(9), С. 593 - 602

Опубликована: Июнь 12, 2020

Язык: Английский

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The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

Antiviral Research, Год журнала: 2020, Номер 177, С. 104760 - 104760

Опубликована: Март 3, 2020

Язык: Английский

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Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

Viruses, Год журнала: 2018, Номер 10(9), С. 497 - 497

Опубликована: Сен. 13, 2018

Influenza A viruses (IAVs) possess a great zoonotic potential as they are able to infect different avian and mammalian animal hosts, from which can be transmitted humans. This is based on the ability of IAV gradually change their genome by mutation or even reassemble segments during co-infection host cell with strains, resulting in high genetic diversity. Variants circulating newly emerging IAVs continue trigger global health threats annually for both humans animals. Here, we provide an introduction IAVs, highlighting mechanisms viral evolution, spectrum, animal/human interface. Pathogenicity determinants mammals, special emphasis pandemic potential, discussed. Finally, overview provided various approaches prevention human infections.

Язык: Английский

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Host-Directed Antiviral Therapy

Clinical Microbiology Reviews, Год журнала: 2020, Номер 33(3)

Опубликована: Май 12, 2020

Antiviral drugs have traditionally been developed by directly targeting essential viral components. However, this strategy often fails due to the rapid generation of drug-resistant viruses. Recent genome-wide approaches, such as those employing small interfering RNA (siRNA) or clustered regularly interspaced short palindromic repeats (CRISPR) using molecule chemical inhibitors cellular “kinome,” used successfully identify factors that can support virus replication.

Язык: Английский

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Ivermectin, a new candidate therapeutic against SARS-CoV-2/COVID-19

Annals of Clinical Microbiology and Antimicrobials, Год журнала: 2020, Номер 19(1)

Опубликована: Май 30, 2020

Язык: Английский

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Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance

New Microbes and New Infections, Год журнала: 2020, Номер 35, С. 100684 - 100684

Опубликована: Апрель 22, 2020

Alarming situation has been caused due to the emergence of COVID-19 infection around world. There is an urgency developing a therapeutic strategy in order control spread COVID-19. Towards that initiative, potential drugs like hydroxychloroquine, ivermectin and azithromycin have tested by diverse group researchers worldwide for their against novel coronavirus. The present report presents together comprehensive knowledge derived from major researches about above altogether context current health emergency Hydroxychloroquine were known act creating acidic environment inhibiting importin (IMPα/β1) mediated viral import. Azithromycin was found similar hydroxychloroquine as acidotropic lipophilic weak base. All three categories seemed potentially coronavirus infection. However, efficacies need be studied detail individually combination in-vivo combat

Язык: Английский

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Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

American Journal of Therapeutics, Год журнала: 2021, Номер 28(3), С. e299 - e318

Опубликована: Апрель 22, 2021

After COVID-19 emerged on U.S shores, providers began reviewing the emerging basic science, translational, and clinical data to identify potentially effective treatment options. In addition, a multitude of both novel repurposed therapeutic agents were used empirically studied within trials.

Язык: Английский

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