The biological inorganic chemistry of zinc ions

Archives of Biochemistry and Biophysics, Год журнала: 2016, Номер 611, С. 3 - 19

Опубликована: Май 1, 2016

The solution and complexation chemistry of zinc ions is the basis for biology. In living organisms, redox-inert has only one valence state: Zn(II). Its coordination environment in proteins limited by oxygen, nitrogen, sulfur donors from side chains a few amino acids. an estimated 10% all human proteins, catalytic or structural function remains bound during lifetime protein. However, other bind reversibly with dissociation association rates commensurate requirements regulation, transport, transfer, sensing, signalling, storage. contrast to extensive knowledge about "mobile" these processes, i.e. when not virtually unexplored mechanisms ligand exchange are poorly understood. Knowledge biological inorganic essential understanding its cellular biology designing complexes that deliver chelating agents remove detecting ion species qualitative quantitative analysis, proper planning execution experiments involving nanoparticles such as oxide (ZnO). most investigations, reference made Zn2+ without full appreciation how buffered d-block cation differs s-block cations Ca2+ regard significantly higher affinity ligands, preference donor atoms dynamics. Zinc needs be tightly controlled. interaction low molecular weight ligands water organic anions highly relevant but been discussed biochemical literature. From discussion this article, it becoming evident speciation important biochemistry recognition variety have already implicated e.g. ATP, glutathione, citrate, ethylenediaminedisuccinic acid, nicotianamine, bacillithiol.

Язык: Английский

---

The interplay between microbial communities and soil properties

Nature Reviews Microbiology, Год журнала: 2023, Номер 22(4), С. 226 - 239

Опубликована: Окт. 20, 2023

Язык: Английский

---

Metals to combat antimicrobial resistance

Nature Reviews Chemistry, Год журнала: 2023, Номер 7(3), С. 202 - 224

Опубликована: Фев. 8, 2023

Bacteria, similar to most organisms, have a love–hate relationship with metals: specific metal may be essential for survival yet toxic in certain forms and concentrations. Metal ions long history of antimicrobial activity received increasing attention recent years owing the rise resistance. The search antibacterial agents now encompasses ions, nanoparticles complexes (‘metalloantibiotics’). Although advanced clinic, metalloantibiotics are vast underexplored group compounds that could lead much-needed new class antibiotics. This Review summarizes developments this growing field, focusing on advances development metalloantibiotics, particular, those which mechanism action has been investigated. We also provide an overview alternative uses combat bacterial infections, including photodynamic therapy radionuclide diagnosis infections. Metals their promising source Their 3D geometry potential multiple mechanisms important assets; however, substantial investment research is needed advance them clinic.

Язык: Английский

---

Synthesis, nature and utility of universal iron chelator – Siderophore: A review

Microbiological Research, Год журнала: 2017, Номер 212-213, С. 103 - 111

Опубликована: Ноя. 2, 2017

Язык: Английский

---

Microbial interactions: ecology in a molecular perspective

Brazilian Journal of Microbiology, Год журнала: 2016, Номер 47, С. 86 - 98

Опубликована: Окт. 26, 2016

The microorganism–microorganism or microorganism–host interactions are the key strategy to colonize and establish in a variety of different environments. These involve all ecological aspects, including physiochemical changes, metabolite exchange, conversion, signaling, chemotaxis genetic exchange resulting genotype selection. In addition, establishment environment depends on species diversity, since high functional redundancy microbial community increases competitive ability community, decreasing possibility an invader this environment. Therefore, these associations result co-evolution process that leads adaptation specialization, allowing occupation niches, by reducing biotic abiotic stress exchanging growth factors signaling. Microbial occur transference molecular information, many mechanisms can be involved such as secondary metabolites, siderophores, quorum sensing system, biofilm formation, cellular transduction among others. ultimate unit interaction is gene expression each organism response environmental (biotic abiotic) stimulus, which responsible for production molecules interactions. present review, we focused some interaction, not only microbial–host has been exploited other reviews, but also used microorganisms modulate structuration community.

Язык: Английский

---

Mortierella Species as the Plant Growth-Promoting Fungi Present in the Agricultural Soils

Agriculture, Год журнала: 2020, Номер 11(1), С. 7 - 7

Опубликована: Дек. 24, 2020

In the most recent scientific reports based on DNA or RNA-analyses a widespread presence of filamentous fungi, Mortierella in various environments has been shown. Some strains this genus belong to plant growth-promoting fungi (PGPF) and are found bulk soil, rhizosphere plants tissues. These microorganisms also often extremely hostile environments, responsible for improving access bioavailable forms P Fe soils, synthesis phytohormones 1-aminocyclopropane-1-carboxylate (ACC) deaminase, last but not least protection agricultural from pathogens. Furthermore, earlier classified spp. as saprotrophic isolated forest litter, nowadays their status very valuable decomposers soils was confirmed. The key features like ability survive under unfavorable environmental conditions utilization carbon sources contained polymers cellulose, hemicellulose, chitin make these efficient inoculants. growing interest application is mainly due potential use increase nutrient uptake efficiency, positive effect crop against adverse conditions, reduction chemical fertilizers pesticides applied. Moreover, activities species selected wild cultivated influence soil microbiota support performance beneficial enhancing significantly yield.

Язык: Английский

---

N -hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis

Proceedings of the National Academy of Sciences, Год журнала: 2018, Номер 115(21)

Опубликована: Май 7, 2018

Systemic acquired resistance (SAR) is a global response in plants induced at the site of infection that leads to long-lasting and broad-spectrum disease distal, uninfected tissues. Despite importance this priming mechanism, identity complexity defense signals are required initiate SAR signaling not well understood. In paper, we describe metabolite, N-hydroxy-pipecolic acid (N-OH-Pip) provide evidence mobile molecule plays role initiating signal transduction Arabidopsis thaliana We demonstrate FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1), key regulator SAR-associated priming, can synthesize N-OH-Pip from pipecolic planta, exogenously applied moves systemically rescue SAR-deficiency fmo1 mutants. also treatment causes systemic changes expression pathogenesis-related genes metabolic pathways throughout plant enhances bacterial pathogen. This work provides insight into chemical nature for suggests pathway promising target engineering enhance resistance.

Язык: Английский

---

<em>Acinetobacter baumannii</em> biofilms: effects of physicochemical factors, virulence, antibiotic resistance determinants, gene regulation, and future antimicrobial treatments

Infection and Drug Resistance, Год журнала: 2018, Номер Volume 11, С. 2277 - 2299

Опубликована: Ноя. 1, 2018

Abstract: Acinetobacter baumannii is a leading cause of nosocomial infections due to its increased antibiotic resistance and virulence. The ability A. form biofilms contributes survival in adverse environmental conditions including hospital environments medical devices. has undoubtedly propelled the interest biomedical researchers broad range associated especially intensive care units. interplay among microbial physicochemistry, alterations phenotype genotypic determinants, impact existing ecological niche chemistry antimicrobial agents led enhanced biofilm formation resulting limited access drugs their specific targets. Understanding triggers step towards limiting containing biofilm-associated development biofilm-specific countermeasures. present review therefore focused on explaining factors, resistance, gene alteration regulation, prevailing ecology gives insights into prospective anti-infective treatments. Keywords: , biofilm, physicochemical, antibiotics, vivo model, virulence, treatment

Язык: Английский

---

Metallo-β-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design

Chemical Reviews, Год журнала: 2021, Номер 121(13), С. 7957 - 8094

Опубликована: Июнь 15, 2021

Antimicrobial resistance is one of the major problems in current practical medicine. The spread genes coding for determinants among bacteria challenges use approved antibiotics, narrowing options treatment. Resistance to carbapenems, last resort a concern. Metallo-β-lactamases (MBLs) hydrolyze penicillins, and cephalosporins, becoming central this problem. These enzymes diverge with respect serine-β-lactamases by exhibiting different fold, active site, catalytic features. Elucidating their mechanism has been big challenge field that limited development useful inhibitors. This review covers exhaustively details active-site chemistries, diversity MBL alleles, against substrates, how information helped developing We also discuss here aspects critical understand success MBLs conferring resistance: molecular dissemination, cell physiology, from biogenesis processing involved transit periplasm, uptake Zn(II) ions upon metal starvation conditions, such as those encountered during an infection. In regard, chemical, biochemical microbiological provide integrative view knowledge MBLs.

Язык: Английский

---

Siderophore conjugates to combat antibiotic-resistant bacteria

RSC Medicinal Chemistry, Год журнала: 2023, Номер 14(5), С. 800 - 822

Опубликована: Янв. 1, 2023

Antimicrobial resistance (AMR) is a global threat to society due the increasing emergence of multi-drug resistant bacteria that are not susceptible our last line defence antibiotics: new approaches needed fight back.

Язык: Английский

---