Journal of the American Chemical Society,
Год журнала:
2020,
Номер
142(24), С. 10571 - 10591
Опубликована: Май 21, 2020
The
ability
to
differentiate
between
highly
similar
C–H
bonds
in
a
given
molecule
remains
fundamental
challenge
organic
chemistry.
In
particular,
the
lack
of
sufficient
steric
and
electronic
differences
located
distal
functional
groups
has
prevented
development
site-selective
catalysts
with
broad
scope.
An
emerging
approach
circumvent
this
obstacle
is
utilize
distance
target
bond
coordinating
group,
along
geometry
cyclic
transition
state
directed
activation,
as
core
molecular
recognition
parameters
multiple
bonds.
Perspective,
we
discuss
advent
recent
advances
concept.
We
cover
wide
range
transition-metal-catalyzed,
template-directed
remote
activation
reactions
alcohols,
carboxylic
acids,
sulfonates,
phosphonates,
amines.
Additionally,
review
eminent
examples
which
take
advantage
non-covalent
interactions
achieve
regiocontrol.
Continued
advancement
distance-
geometry-based
differentiation
for
regioselective
functionalization
may
lead
ultimate
realization
editing:
freedom
modify
molecules
at
any
site,
order.
Angewandte Chemie International Edition,
Год журнала:
2018,
Номер
58(32), С. 10820 - 10843
Опубликована: Ноя. 29, 2018
Directing
group
assisted
ortho-C-H
activation
has
been
known
for
the
last
few
decades.
In
contrast,
extending
same
approach
to
achieve
of
distal
meta-
and
para-C-H
bonds
in
aromatic
molecules
remained
elusive
a
long
time.
The
main
challenge
is
conception
macrocyclic
transition
state,
which
needed
anchor
metal
catalyst
close
target
bond.
Judicious
modification
chain
length,
tether
linkage,
nature
catalyst-coordinating
donor
atom
led
number
successful
studies
years.
This
Review
compiles
significant
achievements
made
this
field
both
para-selectivity
using
covalently
attached
directing
groups,
are
systematically
classified
on
basis
their
mode
covalent
attachment
substrate
as
well
chemical
nature.
aims
create
more
heuristic
recognizing
suitability
groups
use
future
organic
transformations.
Angewandte Chemie International Edition,
Год журнала:
2017,
Номер
57(16), С. 4234 - 4241
Опубликована: Дек. 11, 2017
Direct
functionalization
of
natural
products
is
important
for
studying
the
structure-activity
and
structure-property
relationships
these
molecules.
Recent
advances
in
transition-metal-catalyzed
C(sp3
)-H
bonds,
most
abundant
yet
inert
bonds
products,
have
allowed
product
derivatives
to
be
created
selectively.
Strategies
achieve
such
transformation
are
reviewed.
Angewandte Chemie International Edition,
Год журнала:
2020,
Номер
59(45), С. 19773 - 19786
Опубликована: Июль 20, 2020
Abstract
Transition
metal‐catalyzed
enantioselective
functionalization
of
C−H
bond,
the
most
abundant
functionality
in
organic
molecules,
has
emerged
as
an
expedient
synthetic
approach
to
streamline
synthesis
complex
chiral
molecules.
Despite
significant
progress,
traditional
directing
group‐enabled
strategies
require
additional
steps
for
installation
and
removal
groups
from
target
molecule.
The
recently
developed
asymmetric
using
transient
(
c
TDGs)
offers
a
promising
alternative
that
can
circumvent
this
obstacle
therefore
simplify
process.
In
Minireview,
we
briefly
discuss
advent
recent
advances
emerging
concept,
with
emphasis
on
discussing
creation
various
stereogenic
centers
developments
TDGs.
Applications
natural
product
ligand
derivatizations
are
also
discussed.
We
hope
Minireview
will
highlight
great
potential
strategy
help
inspire
further
endeavors.
ACS Catalysis,
Год журнала:
2015,
Номер
5(3), С. 1863 - 1881
Опубликована: Фев. 10, 2015
Esters
are
valuable
commodity
chemicals
widely
found
in
agrochemicals,
pharmaceuticals,
and
advanced
materials.
They
also
important
synthetic
building
blocks
for
chemical
transformation.
Recent
advances
of
ester
synthesis
via
transition-metal-catalyzed
C–H
activation
have
provided
highly
efficient
atom-economical
alternatives
to
the
traditional
methods.
Herein,
we
summarize
recent
on
activation.
On
basis
modes
reactivity
types
bonds,
alkoxycarbonylation
bonds
with
various
esterification
reagents
will
be
discussed
sections
2
3.
Finally,
hydroesterification/hydroacylation
C–C
or
C–O
double
formate
4
5.
Chemical Communications,
Год журнала:
2017,
Номер
53(22), С. 3165 - 3180
Опубликована: Янв. 1, 2017
Significant
progress
has
been
accomplished
in
directed
C–H
functionalization
through
the
use
of
earth-abundant
and
inexpensive
first-row
transition
metals.
Chemical Communications,
Год журнала:
2017,
Номер
53(41), С. 5584 - 5597
Опубликована: Янв. 1, 2017
The
ability
to
selectively
functionalise
a
specific
C-H
bond
is
long-standing
challenge
due
the
ubiquity
of
such
bonds
in
organic
molecules.
One
most
common
approaches
overcome
this
obstacle
consists
installing
directing
groups
into
substrates
direct
functionalisation
towards
desired
bond,
leaving
behind
group
molecule.
Alternatively,
carboxylic
acids
have
been
employed
as
traceless
that
are
easily
removed
after
acid-directed
installation
functionality.
This
review
focuses
on
development
concept
and
its
application
synthesis
during
last
decade.
